CY1113338T1 - Νεα μεθοδος για συνθεση ιβαμπραδινης και αλατων προσθηκης αυτης - Google Patents

Νεα μεθοδος για συνθεση ιβαμπραδινης και αλατων προσθηκης αυτης

Info

Publication number
CY1113338T1
CY1113338T1 CY20121101086T CY121101086T CY1113338T1 CY 1113338 T1 CY1113338 T1 CY 1113338T1 CY 20121101086 T CY20121101086 T CY 20121101086T CY 121101086 T CY121101086 T CY 121101086T CY 1113338 T1 CY1113338 T1 CY 1113338T1
Authority
CY
Cyprus
Prior art keywords
ibabradin
composition
new method
salt addition
salt
Prior art date
Application number
CY20121101086T
Other languages
English (en)
Inventor
Jean-Louis Peglion
Pascal Caignard
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of CY1113338T1 publication Critical patent/CY1113338T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered

Abstract

Μέθοδος για την σύνθεση ιβαμπραδίνης τύπου (Ι):
CY20121101086T 2010-02-17 2012-11-13 Νεα μεθοδος για συνθεση ιβαμπραδινης και αλατων προσθηκης αυτης CY1113338T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1000657A FR2956401B1 (fr) 2010-02-17 2010-02-17 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP11290091A EP2364972B1 (fr) 2010-02-17 2011-02-16 "Nouveau procédé de synthese de l'Ivabradine et de ses sels d'Addition"

Publications (1)

Publication Number Publication Date
CY1113338T1 true CY1113338T1 (el) 2016-06-22

Family

ID=42133409

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101086T CY1113338T1 (el) 2010-02-17 2012-11-13 Νεα μεθοδος για συνθεση ιβαμπραδινης και αλατων προσθηκης αυτης

Country Status (36)

Country Link
US (1) US8278440B2 (el)
EP (1) EP2364972B1 (el)
JP (1) JP5306387B2 (el)
KR (1) KR101310683B1 (el)
CN (3) CN103265491B (el)
AR (1) AR080178A1 (el)
AU (1) AU2011200403B2 (el)
BR (1) BRPI1100169A2 (el)
CA (1) CA2731315C (el)
CL (1) CL2011000297A1 (el)
CY (1) CY1113338T1 (el)
DK (1) DK2364972T3 (el)
EA (1) EA019373B1 (el)
ES (1) ES2396042T3 (el)
FR (1) FR2956401B1 (el)
GE (1) GEP20135737B (el)
HK (3) HK1162021A1 (el)
HR (1) HRP20120955T1 (el)
JO (1) JO2854B1 (el)
MA (1) MA32681B1 (el)
ME (1) ME01464B (el)
MX (1) MX2011001465A (el)
MY (1) MY147697A (el)
NZ (1) NZ590883A (el)
PE (1) PE20120576A1 (el)
PL (1) PL2364972T3 (el)
PT (1) PT2364972E (el)
RS (1) RS52529B (el)
SA (1) SA111320199B1 (el)
SG (1) SG173961A1 (el)
SI (1) SI2364972T1 (el)
TW (1) TWI395738B (el)
UA (1) UA106208C2 (el)
UY (1) UY33211A (el)
WO (1) WO2011101558A1 (el)
ZA (1) ZA201100964B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2950343B1 (fr) * 2009-09-18 2011-11-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN102566619B (zh) * 2012-02-07 2013-12-25 宁波市镇海华泰电器厂 噪声式水温控制装置
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
FR2681862B1 (fr) 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
WO2002051232A2 (en) 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
WO2003099206A2 (en) * 2002-05-21 2003-12-04 Bristol-Myers Squibb Company Indole compounds useful as impdh inhibitors
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
TW200817334A (en) * 2005-02-07 2008-04-16 Servier Lab New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
WO2008065681A2 (en) * 2006-11-30 2008-06-05 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
CN101284813B (zh) * 2007-04-12 2012-08-15 上海优拓医药科技有限公司 伊伐布雷定的制备方法
RU2473544C2 (ru) * 2007-05-30 2013-01-27 Инд-Свифт Лабораториз Лимитед Способ получения ивабрадина гидрохлорида и его полиморфных модификаций
CN101544605A (zh) * 2008-03-24 2009-09-30 北京深蓝海生物医药科技有限公司 伊伐布雷定及其药学上可接受的加成盐的制备方法
FR2932800B1 (fr) 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2010072409A1 (en) 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Process for preparation of ivabradine

Also Published As

Publication number Publication date
JP5306387B2 (ja) 2013-10-02
BRPI1100169A2 (pt) 2012-07-31
EA201100230A1 (ru) 2011-08-30
CA2731315C (fr) 2013-03-26
JP2011168590A (ja) 2011-09-01
ME01464B (me) 2014-04-20
KR101310683B1 (ko) 2013-09-24
US8278440B2 (en) 2012-10-02
AR080178A1 (es) 2012-03-21
EP2364972A1 (fr) 2011-09-14
EP2364972B1 (fr) 2012-09-19
MX2011001465A (es) 2011-08-30
KR20110095210A (ko) 2011-08-24
DK2364972T3 (da) 2013-01-07
CN102161642A (zh) 2011-08-24
AU2011200403A1 (en) 2011-09-01
HK1183488A1 (en) 2013-12-27
CA2731315A1 (fr) 2011-08-17
CN103232360B (zh) 2014-05-21
CN103265491B (zh) 2015-01-21
FR2956401B1 (fr) 2012-02-03
CN103232360A (zh) 2013-08-07
CL2011000297A1 (es) 2012-02-17
PL2364972T3 (pl) 2013-01-31
MA32681B1 (fr) 2011-10-02
WO2011101558A1 (fr) 2011-08-25
MY147697A (en) 2013-01-07
TWI395738B (zh) 2013-05-11
US20110201805A1 (en) 2011-08-18
HRP20120955T1 (hr) 2012-12-31
PT2364972E (pt) 2012-10-02
HK1183295A1 (en) 2013-12-20
RS52529B (en) 2013-04-30
TW201144287A (en) 2011-12-16
SI2364972T1 (sl) 2012-12-31
ES2396042T3 (es) 2013-02-18
HK1162021A1 (en) 2012-08-17
GEP20135737B (en) 2013-01-25
JO2854B1 (en) 2015-03-15
NZ590883A (en) 2012-01-12
EA019373B1 (ru) 2014-03-31
PE20120576A1 (es) 2012-05-12
UY33211A (el) 2011-07-29
CN103265491A (zh) 2013-08-28
SG173961A1 (en) 2011-09-29
ZA201100964B (en) 2011-10-26
UA106208C2 (ru) 2014-08-11
FR2956401A1 (fr) 2011-08-19
CN102161642B (zh) 2014-03-19
SA111320199B1 (ar) 2014-05-21
AU2011200403B2 (en) 2015-02-19

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