PE20100260A1 - Formas solidas del (2s, 3r, 4r, 5s, 6r)-2-(4-cloro-3-(4-etoxibenzil)fenil)-6-(metiltio) tetrahidro-2h-pirano-3,4,5-triol - Google Patents

Formas solidas del (2s, 3r, 4r, 5s, 6r)-2-(4-cloro-3-(4-etoxibenzil)fenil)-6-(metiltio) tetrahidro-2h-pirano-3,4,5-triol

Info

Publication number
PE20100260A1
PE20100260A1 PE2009000944A PE2009000944A PE20100260A1 PE 20100260 A1 PE20100260 A1 PE 20100260A1 PE 2009000944 A PE2009000944 A PE 2009000944A PE 2009000944 A PE2009000944 A PE 2009000944A PE 20100260 A1 PE20100260 A1 PE 20100260A1
Authority
PE
Peru
Prior art keywords
methylthi
pyrane
ethoxybenzyl
triol
tetrahydro
Prior art date
Application number
PE2009000944A
Other languages
English (en)
Inventor
Paul Susan Margaret De
Anett Perlberg
Matthew Mangzhu Zhao
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of PE20100260A1 publication Critical patent/PE20100260A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO CRISTALINO (2S,3R,4R, 5S, 6R)-2-(4-CLORO-3-(4-ETOXIBENZIL)FENIL)-6-(METILTIO) TETRAHIDRO-2H-PIRANO-3,4,5-TRIOL ANHIDRO AMORFO, CARACTERIZADO CON UN ENDOTERMA DSC CERCANA A 124 ºC ; QUE TIENE UN PATRON DE DIFRACCION DE RAYOS X CON MAXIMOS A UNO O MAS DE 4.0, 8.1, 9,8, 14.0 Y/O 19.3 GRADOS 2 TETHA. TAMBIEN SE REFIERE A UN METODO DE PREPARACION PARA UNA FORMA FARMACEUTICA SOLIDA. DICHO COMPUESTO ES INHIBIDOR DEL SGL T2, SIENDO UTIL EN EL TRATAMIENTO TRASTORNOS METABOLICOS TAL COMO DIABETES TIPO I Y II, ATEROESCLEROSIS, OBESIDAD ENTRE OTRAS
PE2009000944A 2008-07-17 2009-07-15 Formas solidas del (2s, 3r, 4r, 5s, 6r)-2-(4-cloro-3-(4-etoxibenzil)fenil)-6-(metiltio) tetrahidro-2h-pirano-3,4,5-triol PE20100260A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8142308P 2008-07-17 2008-07-17

Publications (1)

Publication Number Publication Date
PE20100260A1 true PE20100260A1 (es) 2010-04-16

Family

ID=41137707

Family Applications (1)

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PE2009000944A PE20100260A1 (es) 2008-07-17 2009-07-15 Formas solidas del (2s, 3r, 4r, 5s, 6r)-2-(4-cloro-3-(4-etoxibenzil)fenil)-6-(metiltio) tetrahidro-2h-pirano-3,4,5-triol

Country Status (29)

Country Link
US (2) US8217156B2 (es)
EP (1) EP2332947B1 (es)
JP (2) JP2011528366A (es)
KR (2) KR20170010069A (es)
CN (2) CN102112483A (es)
AR (1) AR072807A1 (es)
AU (1) AU2009270973B2 (es)
BR (1) BRPI0916191A2 (es)
CA (1) CA2730931A1 (es)
CL (1) CL2009001595A1 (es)
CO (1) CO6351797A2 (es)
DK (1) DK2332947T3 (es)
ES (1) ES2656357T3 (es)
HK (1) HK1243713A1 (es)
HU (1) HUE035400T2 (es)
IL (1) IL210269A (es)
MX (1) MX2011000503A (es)
NO (1) NO2332947T3 (es)
NZ (1) NZ590184A (es)
PE (1) PE20100260A1 (es)
PL (1) PL2332947T3 (es)
PT (1) PT2332947T (es)
RU (1) RU2505543C2 (es)
SG (1) SG185317A1 (es)
TW (1) TWI472521B (es)
UA (1) UA106048C2 (es)
UY (1) UY31992A (es)
WO (1) WO2010009197A1 (es)
ZA (1) ZA201100175B (es)

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TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
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TWI631963B (zh) * 2011-01-05 2018-08-11 雷西肯製藥股份有限公司 包含鈉－葡萄糖共同輸送體１與２之抑制劑的組合物與應用方法
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JP2021520394A (ja) 2018-04-17 2021-08-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 医薬組成物、処置方法及びその使用
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SG185317A1 (en) 2012-11-29
ZA201100175B (en) 2012-03-28
RU2505543C2 (ru) 2014-01-27
US20100016422A1 (en) 2010-01-21
TWI472521B (zh) 2015-02-11
CN102112483A (zh) 2011-06-29
DK2332947T3 (da) 2018-01-29
JP2011528366A (ja) 2011-11-17
ES2656357T3 (es) 2018-02-26
JP6283337B2 (ja) 2018-02-21
MX2011000503A (es) 2011-03-01
PT2332947T (pt) 2018-02-06
CA2730931A1 (en) 2010-01-21
AR072807A1 (es) 2010-09-22
EP2332947A1 (en) 2011-06-15
TW201006808A (en) 2010-02-16
US20130165395A1 (en) 2013-06-27
WO2010009197A1 (en) 2010-01-21
AU2009270973B2 (en) 2014-01-30
UA106048C2 (uk) 2014-07-25
CO6351797A2 (es) 2011-12-20
KR20170010069A (ko) 2017-01-25
PL2332947T3 (pl) 2018-04-30
JP2016041701A (ja) 2016-03-31
IL210269A0 (en) 2011-03-31
HUE035400T2 (en) 2018-05-02
RU2011105797A (ru) 2012-08-27
BRPI0916191A2 (pt) 2017-08-29
HK1243713A1 (zh) 2018-07-20
NO2332947T3 (es) 2018-03-31
CN107629097A (zh) 2018-01-26
EP2332947B1 (en) 2017-11-01
KR20110031196A (ko) 2011-03-24
AU2009270973A1 (en) 2010-01-21
CL2009001595A1 (es) 2010-07-19
NZ590184A (en) 2012-09-28
US8217156B2 (en) 2012-07-10
IL210269A (en) 2015-06-30
UY31992A (es) 2010-02-26
US9067962B2 (en) 2015-06-30
KR101707246B1 (ko) 2017-02-15

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