PE20100234A1 - Nuevo procedimiento de resolucion de enantiomeros de (3,4-dimetoxi-biciclo[4.2.0]octa-1,3,5-trien-7-il)nitrilo y aplicacion en la sintesis de ivabradina - Google Patents
Nuevo procedimiento de resolucion de enantiomeros de (3,4-dimetoxi-biciclo[4.2.0]octa-1,3,5-trien-7-il)nitrilo y aplicacion en la sintesis de ivabradinaInfo
- Publication number
- PE20100234A1 PE20100234A1 PE2009001000A PE2009001000A PE20100234A1 PE 20100234 A1 PE20100234 A1 PE 20100234A1 PE 2009001000 A PE2009001000 A PE 2009001000A PE 2009001000 A PE2009001000 A PE 2009001000A PE 20100234 A1 PE20100234 A1 PE 20100234A1
- Authority
- PE
- Peru
- Prior art keywords
- dimetoxi
- trien
- octa
- nitrile
- biciclo
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/48—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE RESOLUCION OPTICA DE (3,4-DIMETOXI-BICICLO[4.2.0]OCTA-1,3,5-TRIEN-7-IL)NITRILO EN EL QUE SE SEPARA DICHO COMPUESTO EN SUS DOS ENANTIOMEROS POR CROMATOGRAFIA QUIRAL, EN DONDE DICHO PROCEDIMIENTO EMPLEA LA SEPARACION MULTI-COLUMNAS EN CONTINUO O CROMATOGRAFIA EN LECHO MOVIL SIMULADO A UNA TEMPERATURA DE 15ºC A 40ºC CUYA A) FASE ESTACIONARIA COMPRENDE UN GEL DE SILICE IMPREGNADO CON UN POLISACARIDO FUNCIONALIZADO TAL COMO UN DERIVADO CELULOSICO O AMILOSICO DE TRIS(4-METILBENZOATO) O DE TRIS(3,5-DIMETILFENILCARBAMATO); Y B) LA FASE MOVIL QUE SE RECICLA COMPRENDE ISOPROPANOL, UN DISOLVENTE ORGANICO TAL COMO HEPTANO O HEXANO, O UNA MEZCLA DE AMBOS RESPECTIVAMENTE EN UNA PROPORCION DE 50:50 A 2:98. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE SINTESIS DE IVABRADINA QUE UTILIZA EL ENANTIOMERO (S)-(3,4-DIMETOXI-BICICLO[4.2.0]OCTA-1,3,5-TRIEN-7-IL)NITRILO OBTENIDO DE LA RESOLUCION OPTICA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0804755A FR2935381B1 (fr) | 2008-08-29 | 2008-08-29 | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20100234A1 true PE20100234A1 (es) | 2010-03-27 |
Family
ID=40431490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009001000A PE20100234A1 (es) | 2008-08-29 | 2009-08-03 | Nuevo procedimiento de resolucion de enantiomeros de (3,4-dimetoxi-biciclo[4.2.0]octa-1,3,5-trien-7-il)nitrilo y aplicacion en la sintesis de ivabradina |
Country Status (39)
Country | Link |
---|---|
US (3) | US8536365B2 (es) |
EP (1) | EP2166004B1 (es) |
JP (2) | JP5663154B2 (es) |
KR (1) | KR101119309B1 (es) |
CN (1) | CN101659631B (es) |
AR (1) | AR073147A1 (es) |
AT (1) | ATE483688T1 (es) |
AU (1) | AU2009208068B2 (es) |
BR (1) | BRPI0903051A2 (es) |
CA (1) | CA2676712C (es) |
CL (1) | CL2009001758A1 (es) |
CY (1) | CY1110943T1 (es) |
DE (1) | DE602009000256D1 (es) |
DK (1) | DK2166004T3 (es) |
EA (1) | EA015777B1 (es) |
ES (1) | ES2353251T3 (es) |
FR (1) | FR2935381B1 (es) |
GE (1) | GEP20125409B (es) |
HK (1) | HK1141511A1 (es) |
HR (1) | HRP20100679T1 (es) |
JO (1) | JO2786B1 (es) |
MA (1) | MA31228B1 (es) |
ME (1) | ME00835B (es) |
MX (1) | MX2009008443A (es) |
MY (1) | MY145992A (es) |
NZ (1) | NZ579270A (es) |
PA (1) | PA8840901A1 (es) |
PE (1) | PE20100234A1 (es) |
PL (1) | PL2166004T3 (es) |
PT (1) | PT2166004E (es) |
RS (1) | RS51554B (es) |
SA (1) | SA109300533B1 (es) |
SG (1) | SG159454A1 (es) |
SI (1) | SI2166004T1 (es) |
TW (1) | TWI404705B (es) |
UA (1) | UA105890C2 (es) |
UY (1) | UY32034A (es) |
WO (1) | WO2010023383A1 (es) |
ZA (1) | ZA200905566B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2473544C2 (ru) | 2007-05-30 | 2013-01-27 | Инд-Свифт Лабораториз Лимитед | Способ получения ивабрадина гидрохлорида и его полиморфных модификаций |
FR2935381B1 (fr) * | 2008-08-29 | 2010-12-17 | Servier Lab | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine |
CN101774969B (zh) * | 2009-01-13 | 2012-07-04 | 江苏恒瑞医药股份有限公司 | 硫酸伊伐布雷定及其i型结晶的制备方法 |
HUP1000245A2 (en) * | 2010-05-07 | 2011-11-28 | Richter Gedeon Nyrt | Industrial process for the production ivabradin salts |
EP2522647B1 (en) * | 2011-05-10 | 2014-04-30 | DSM IP Assets B.V. | Process of separating chiral isomers of chroman compounds and their derivatives and precursors |
FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2984319B1 (fr) * | 2011-12-20 | 2013-12-27 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2986804A1 (fr) * | 2012-02-09 | 2013-08-16 | Servier Lab | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels |
FR2993561B1 (fr) * | 2012-07-17 | 2014-10-31 | Servier Lab | Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels |
FR3002542B1 (fr) | 2013-02-28 | 2016-01-22 | Servier Lab | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique et application a la synthese de l'ivabradine et de ses sels |
EP3101010A1 (en) | 2015-06-03 | 2016-12-07 | Urquima S.A. | New method for the preparation of highly pure ivabradine base and salts thereof |
CN106390519A (zh) * | 2016-09-12 | 2017-02-15 | 华东理工大学 | 多柱模拟移动床色谱技术连续分离氨鲁米特外消旋体的方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5246948B2 (es) * | 1972-04-26 | 1977-11-29 | ||
IE52768B1 (en) * | 1981-04-06 | 1988-02-17 | Boots Co Ltd | 1-arylcyclobutylalkylamine compounds useful as therapeutic agents |
DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
FR2539415B1 (fr) * | 1983-01-14 | 1985-09-13 | Adir | Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique |
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
US5269482A (en) * | 1991-09-30 | 1993-12-14 | Shearing Ernest J | Protective enclosure apparatus for magnetic propulsion space vehicle |
EP0977031B1 (en) * | 1997-04-15 | 2009-04-29 | Hideyuki Nishizawa | Solid-liquid countercurrent extraction continuously separating apparatus |
GB0325055D0 (en) * | 2003-10-27 | 2003-12-03 | Smithkline Beecham Corp | New process |
FR2868777B1 (fr) | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2870537A1 (fr) * | 2004-05-19 | 2005-11-25 | Servier Lab | Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
CA2664855C (en) * | 2006-09-29 | 2014-04-29 | Council Of Scientific & Industrial Research | Organic-inorganic hybrid chiral sorbent and process for the preparation thereof |
FR2935381B1 (fr) * | 2008-08-29 | 2010-12-17 | Servier Lab | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine |
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2008
- 2008-08-29 FR FR0804755A patent/FR2935381B1/fr not_active Expired - Fee Related
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2009
- 2009-08-03 PE PE2009001000A patent/PE20100234A1/es active IP Right Grant
- 2009-08-03 SG SG200905168-1A patent/SG159454A1/en unknown
- 2009-08-04 UY UY0001032034A patent/UY32034A/es not_active Application Discontinuation
- 2009-08-06 MY MYPI20093265A patent/MY145992A/en unknown
- 2009-08-07 MX MX2009008443A patent/MX2009008443A/es active IP Right Grant
- 2009-08-07 AU AU2009208068A patent/AU2009208068B2/en not_active Ceased
- 2009-08-11 ZA ZA200905566A patent/ZA200905566B/xx unknown
- 2009-08-12 MA MA32165A patent/MA31228B1/fr unknown
- 2009-08-13 JO JO2009309A patent/JO2786B1/en active
- 2009-08-19 TW TW098127907A patent/TWI404705B/zh not_active IP Right Cessation
- 2009-08-21 CL CL2009001758A patent/CL2009001758A1/es unknown
- 2009-08-24 US US12/583,632 patent/US8536365B2/en not_active Expired - Fee Related
- 2009-08-25 CN CN2009101673775A patent/CN101659631B/zh not_active Expired - Fee Related
- 2009-08-25 GE GEAP200911437A patent/GEP20125409B/en unknown
- 2009-08-25 SA SA109300533A patent/SA109300533B1/ar unknown
- 2009-08-26 NZ NZ579270A patent/NZ579270A/en not_active IP Right Cessation
- 2009-08-27 RS RSP-2011/0002A patent/RS51554B/en unknown
- 2009-08-27 DE DE602009000256T patent/DE602009000256D1/de active Active
- 2009-08-27 AR ARP090103297A patent/AR073147A1/es not_active Application Discontinuation
- 2009-08-27 UA UAA200908942A patent/UA105890C2/uk unknown
- 2009-08-27 CA CA2676712A patent/CA2676712C/fr not_active Expired - Fee Related
- 2009-08-27 ES ES09290646T patent/ES2353251T3/es active Active
- 2009-08-27 ME MEP-2009-277A patent/ME00835B/me unknown
- 2009-08-27 KR KR1020090079693A patent/KR101119309B1/ko active IP Right Grant
- 2009-08-27 SI SI200930009T patent/SI2166004T1/sl unknown
- 2009-08-27 WO PCT/FR2009/001036 patent/WO2010023383A1/fr active Application Filing
- 2009-08-27 AT AT09290646T patent/ATE483688T1/de active
- 2009-08-27 BR BRPI0903051-4A patent/BRPI0903051A2/pt not_active Application Discontinuation
- 2009-08-27 EP EP09290646A patent/EP2166004B1/fr active Active
- 2009-08-27 PL PL09290646T patent/PL2166004T3/pl unknown
- 2009-08-27 DK DK09290646.0T patent/DK2166004T3/da active
- 2009-08-27 PT PT09290646T patent/PT2166004E/pt unknown
- 2009-08-28 EA EA200901051A patent/EA015777B1/ru not_active IP Right Cessation
- 2009-08-28 JP JP2009197747A patent/JP5663154B2/ja active Active
- 2009-08-28 PA PA20098840901A patent/PA8840901A1/es unknown
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2010
- 2010-08-23 HK HK10108025.0A patent/HK1141511A1/xx not_active IP Right Cessation
- 2010-11-29 CY CY20101101088T patent/CY1110943T1/el unknown
- 2010-12-07 HR HR20100679T patent/HRP20100679T1/hr unknown
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2013
- 2013-03-26 US US13/850,501 patent/US8927758B2/en not_active Expired - Fee Related
- 2013-03-26 US US13/850,514 patent/US8778930B2/en not_active Expired - Fee Related
- 2013-06-20 JP JP2013129363A patent/JP5746733B2/ja active Active
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