PE20091262A1 - Compuestos de diarilhidantoina como antagonistas del receptor de androgeno - Google Patents
Compuestos de diarilhidantoina como antagonistas del receptor de androgenoInfo
- Publication number
- PE20091262A1 PE20091262A1 PE2008001821A PE2008001821A PE20091262A1 PE 20091262 A1 PE20091262 A1 PE 20091262A1 PE 2008001821 A PE2008001821 A PE 2008001821A PE 2008001821 A PE2008001821 A PE 2008001821A PE 20091262 A1 PE20091262 A1 PE 20091262A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- androgen receptor
- thioxo
- oxo
- phenyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
REFERIDA A UN DERIVADO DE DIARILHIDANTOINA DE FORMULA (I), DONDE R1 Y R2 SON ALQUILO C1-C8, CICLOALQUILO C3-C20, ENTRE OTROS; R3 ES H, CN, FORMILO, IMIDAZOL, ENTRE OTROS; R4 ES H, F, Cl, Br, I; R11 Y R12 SON H O METILO. SON COMPUESTOS PREFERIDOS: 4-(3-(4-(3-CIANOPROPIL)FENIL)-4,4-DIMETIL-5-OXO-2-TIOXO-IMIDAZOLIDIN-1-IL)-2-(TRIFLUOROMETIL)BENZONITRILO, 4-(1-(4-(3-CIANOPROPIL)FENIL)-4-OXO-2-TIOXO-1,3-DIAZASPIRO[4,4]NON-3-IL)-2-TRIFLUOROMETILBENZONITRILO, 4-(8-OXO-5-(4-(4-OXOBUTIL)FENIL)-6-TIOXO-5,7-DIAZASPIRO[3.4]OCTAN-7-IL)-2-(TRIFLUOROMETIL)BENZONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD ANTAGONISTA SOBRE EL RECEPTOR DE ANDROGENO (AR) Y SON UTILES EN EL TRATAMIENTO DEL CANCER DE PROSTATA REFRACTARIO A LA HORMONA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99607607P | 2007-10-26 | 2007-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091262A1 true PE20091262A1 (es) | 2009-09-09 |
Family
ID=40278902
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001821A PE20091262A1 (es) | 2007-10-26 | 2008-10-24 | Compuestos de diarilhidantoina como antagonistas del receptor de androgeno |
PE2012000638A PE20121470A1 (es) | 2007-10-26 | 2008-10-24 | Compuestos de diarilhidantoina como antagonistas del receptor de androgeno |
PE2017000081A PE20170428A1 (es) | 2007-10-26 | 2008-10-24 | Compuestos de diarilhidantoina |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012000638A PE20121470A1 (es) | 2007-10-26 | 2008-10-24 | Compuestos de diarilhidantoina como antagonistas del receptor de androgeno |
PE2017000081A PE20170428A1 (es) | 2007-10-26 | 2008-10-24 | Compuestos de diarilhidantoina |
Country Status (11)
Country | Link |
---|---|
US (2) | US8680291B2 (es) |
EP (3) | EP2220050A2 (es) |
JP (4) | JP5535925B2 (es) |
AR (1) | AR069039A1 (es) |
CA (2) | CA2966280A1 (es) |
CL (1) | CL2008003158A1 (es) |
HK (1) | HK1165198A1 (es) |
PE (3) | PE20091262A1 (es) |
TW (3) | TWI557111B (es) |
UY (1) | UY31432A1 (es) |
WO (1) | WO2009055053A2 (es) |
Families Citing this family (28)
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US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
CN102755318B (zh) | 2006-03-29 | 2014-09-10 | 加利福尼亚大学董事会 | 二芳基硫代乙内酰脲化合物 |
JP5535925B2 (ja) * | 2007-10-26 | 2014-07-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アンドロゲン受容体調節物質としてのジアリールヒダントイン化合物 |
SG10201402628VA (en) | 2009-02-24 | 2014-10-30 | Medivation Prostate Therapeutics Inc | Specific Diarylhydantoin And Diarylthiohydantoin Compounds |
EP2416657A4 (en) * | 2009-04-09 | 2012-09-05 | Medivation Prostate Therapeutics Inc | COMPOUNDS COMPRISING SUBSTITUTED DI-ARYLHYDANTOIDS AND DI-ARYLTHIOHYDANTOINES AND METHODS OF USE THEREOF |
KR101456994B1 (ko) | 2009-09-10 | 2014-11-04 | 통유지 | 안드로겐 수용체 길항제 및 그의 용도 |
TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
WO2011044327A1 (en) | 2009-10-07 | 2011-04-14 | Medivation Prostate Therapeutics, Inc. | Substituted phenylcarbamoyl alkylamino arene compounds and n,n'-bis-arylurea compounds |
AR078793A1 (es) | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
SI3124481T1 (en) * | 2010-02-16 | 2018-06-29 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and their use |
EP2538785B1 (en) | 2010-02-24 | 2018-03-21 | Medivation Prostate Therapeutics LLC | Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds |
US20130231385A1 (en) * | 2010-05-28 | 2013-09-05 | The Board Of Regents Of The University Of Texas Systems | Oligo-benzamide compounds and their use |
WO2012065051A1 (en) | 2010-11-12 | 2012-05-18 | Enzon Pharmaceuticals, Inc. | Compositions and methods for treating androgen receptor dependent disorders including cancers |
BR112013023028B1 (pt) * | 2011-03-10 | 2021-09-21 | Suzhou Kintor Pharmaceuticals, Inc | Composto de fórmula (i) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica e formulação farmacêutica tópica |
WO2012143599A1 (en) | 2011-04-21 | 2012-10-26 | Orion Corporation | Androgen receptor modulating carboxamides |
EP3791724A1 (en) | 2011-07-29 | 2021-03-17 | Medivation Prostate Therapeutics LLC | Treatment of breast cancer |
UY34646A (es) | 2012-03-02 | 2013-10-31 | Novartis Ag | Compuestos de espirohidantoína y su uso como moduladores selectivos del receptor de andrógenos |
CA2877786C (en) * | 2012-06-26 | 2020-08-25 | Bayer Pharma Aktiengesellschaft | N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products |
SI3305285T1 (sl) | 2012-09-26 | 2021-03-31 | Aragon Pharmaceuticals, Inc. | Anti-androgeni za zdravljenje proti kastraciji odpornega ne-metastatskega raka |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
US10196693B2 (en) | 2014-12-12 | 2019-02-05 | Medivation Prostate Therapeutics Llc | Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer |
CN106146403B (zh) * | 2015-04-02 | 2018-11-20 | 正大天晴药业集团股份有限公司 | 一种恩杂鲁胺的纯化方法 |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
JP7201694B2 (ja) | 2017-10-16 | 2023-01-10 | アラゴン ファーマシューティカルズ,インコーポレイテッド | 非転移性去勢抵抗性前立腺癌の治療のための抗アンドロゲン剤 |
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- 2008-10-24 JP JP2010531057A patent/JP5535925B2/ja active Active
- 2008-10-24 PE PE2008001821A patent/PE20091262A1/es not_active Application Discontinuation
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- 2008-10-24 WO PCT/US2008/012149 patent/WO2009055053A2/en active Application Filing
- 2008-10-24 PE PE2017000081A patent/PE20170428A1/es not_active Application Discontinuation
- 2008-10-24 AR ARP080104661A patent/AR069039A1/es unknown
- 2008-10-24 EP EP13157028.5A patent/EP2620432A3/en not_active Withdrawn
- 2008-10-24 TW TW105126199A patent/TW201716385A/zh unknown
- 2008-10-24 EP EP11178889.9A patent/EP2397469B1/en active Active
- 2008-10-24 US US12/257,743 patent/US8680291B2/en active Active
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- 2014-03-24 US US14/224,005 patent/US9896437B2/en active Active
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JP2017052796A (ja) | 2017-03-16 |
EP2397469B1 (en) | 2014-12-31 |
US8680291B2 (en) | 2014-03-25 |
WO2009055053A2 (en) | 2009-04-30 |
US20090111864A1 (en) | 2009-04-30 |
TWI469971B (zh) | 2015-01-21 |
CA2703635C (en) | 2017-06-27 |
CA2966280A1 (en) | 2009-04-30 |
CL2008003158A1 (es) | 2009-05-29 |
JP5535925B2 (ja) | 2014-07-02 |
JP2015180672A (ja) | 2015-10-15 |
EP2620432A2 (en) | 2013-07-31 |
CA2703635A1 (en) | 2009-04-30 |
EP2397469A1 (en) | 2011-12-21 |
PE20121470A1 (es) | 2012-11-18 |
EP2220050A2 (en) | 2010-08-25 |
US9896437B2 (en) | 2018-02-20 |
WO2009055053A3 (en) | 2009-06-11 |
PE20170428A1 (es) | 2017-05-14 |
TWI557111B (zh) | 2016-11-11 |
JP2014074070A (ja) | 2014-04-24 |
UY31432A1 (es) | 2009-05-29 |
AR069039A1 (es) | 2009-12-23 |
TW200934762A (en) | 2009-08-16 |
JP2011500813A (ja) | 2011-01-06 |
TW201716385A (zh) | 2017-05-16 |
TW201522315A (zh) | 2015-06-16 |
JP5914538B2 (ja) | 2016-05-11 |
HK1165198A1 (en) | 2012-09-28 |
US20150065546A1 (en) | 2015-03-05 |
EP2620432A3 (en) | 2013-12-18 |
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