PE20070326A1 - Procedimiento para la preparacion de compuestos de 1-[ciano(4-hidroxifenil)metil]ciclohexanol - Google Patents

Procedimiento para la preparacion de compuestos de 1-[ciano(4-hidroxifenil)metil]ciclohexanol

Info

Publication number
PE20070326A1
PE20070326A1 PE2006000749A PE2006000749A PE20070326A1 PE 20070326 A1 PE20070326 A1 PE 20070326A1 PE 2006000749 A PE2006000749 A PE 2006000749A PE 2006000749 A PE2006000749 A PE 2006000749A PE 20070326 A1 PE20070326 A1 PE 20070326A1
Authority
PE
Peru
Prior art keywords
preparation
compounds
cyclohexanol
methyl
procedure
Prior art date
Application number
PE2006000749A
Other languages
English (en)
Inventor
Frieder Mitzel
Beat Theodor Weber
Richard Haldimann
Hans-Rudolf Marti
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070326A1 publication Critical patent/PE20070326A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE 1-[CIANO(FENIL)METIL]CICLOHEXANOL DE FORMULA (I), DONDE R1 ES H, ALQUILO(C1-C4) O ALCOXI(C1-C4), QUE COMPRENDE A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON CICLOHEXANONA EN PRESENCIA DE UNA BASE ORGANICA TAL COMO ALCOHOLATO DE SODIO Y DE POTASIO DE METANOL, ALCOHOLATO DE MAGNESIO DE ETANOL, ALCOHOLATO DE ALUMINIO DE METANOL, ENTRE OTROS, QUE SE ENCUENTRA EN UNA CANTIDAD DE 1,0 A 2,5 MOLES, O INORGANICA TAL COMO HIDROXIDO DE SADIO, DE POTASIO, DE MAGNESIO, ENTRE OTROS, UTILIZADOS EN COMBINACION CON UN ALCOHOL; Y OPCIONALMENTE EN PRESENCIA DE UN DISOLVENTE INERTE TAL COMO PENTANO, HEXANO, BENCENO, ENTRE OTROS; B) AILAR EL PRODUCTO DESPUES DE ANADIR EL DISOLVENTE; Y C) PURIFICAR EL PRODUCTO. DICHA REACCION SE LLEVA A CABO A UNA TEMPERATURA DE 15ºC A 25ºC. DICHOS COMPUESTOS OBTENIDOS SON INTERMEDIARIOS PARA LA PREPARACION DE O-DESMETIL-VENLAFAXINA
PE2006000749A 2005-06-29 2006-06-28 Procedimiento para la preparacion de compuestos de 1-[ciano(4-hidroxifenil)metil]ciclohexanol PE20070326A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH11012005 2005-06-29

Publications (1)

Publication Number Publication Date
PE20070326A1 true PE20070326A1 (es) 2007-05-30

Family

ID=35945318

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000749A PE20070326A1 (es) 2005-06-29 2006-06-28 Procedimiento para la preparacion de compuestos de 1-[ciano(4-hidroxifenil)metil]ciclohexanol

Country Status (21)

Country Link
US (1) US20070021627A1 (es)
EP (1) EP1902015A1 (es)
JP (1) JP2008546818A (es)
KR (1) KR20080031910A (es)
CN (1) CN101238094A (es)
AR (1) AR057416A1 (es)
AU (1) AU2006264012A1 (es)
BR (1) BRPI0612896A2 (es)
CA (1) CA2613689A1 (es)
CR (1) CR9665A (es)
EC (1) ECSP088115A (es)
GT (1) GT200600284A (es)
IL (1) IL188070A0 (es)
MX (1) MX2007016049A (es)
NO (1) NO20080447L (es)
PE (1) PE20070326A1 (es)
RU (1) RU2008103285A (es)
SV (1) SV2007002591A (es)
TW (1) TW200704632A (es)
WO (1) WO2007000294A1 (es)
ZA (1) ZA200800746B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1824815A2 (en) * 2005-10-19 2007-08-29 Teva Pharmaceutical Industries Ltd. Process for the preparation of highly pure 1-[2-dimethylamino-(4-methoxyphenyl) ethyl]cyclohexanol hydrochloride
US7605290B2 (en) 2006-07-26 2009-10-20 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of O-desmethylvenlafaxine
WO2008013993A2 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
WO2011121452A2 (en) 2010-03-29 2011-10-06 Pliva Hrvatska D.O.O. Crystal forms of o-desmethylvenlafaxine fumarate
DK201500161U3 (da) * 2015-12-30 2016-04-25 Ke Aarhus Holding Aps Informationsterminal til montage på kundevogn

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56324B1 (en) * 1982-12-13 1991-06-19 American Home Prod Phenethylamine derivatives and intermediates therefor
JP2002006225A (ja) * 2000-06-23 2002-01-09 Nikon Corp 顕微鏡照明装置
US6504044B2 (en) * 2001-02-28 2003-01-07 Council Of Scientific And Industrial Research Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol
KR20030000217A (ko) * 2001-06-22 2003-01-06 와이어쓰 시클로헥사놀 유도체의 제조방법

Also Published As

Publication number Publication date
SV2007002591A (es) 2007-02-27
GT200600284A (es) 2007-09-05
IL188070A0 (en) 2008-03-20
JP2008546818A (ja) 2008-12-25
CA2613689A1 (en) 2007-01-04
AU2006264012A1 (en) 2007-01-04
NO20080447L (no) 2008-01-23
US20070021627A1 (en) 2007-01-25
BRPI0612896A2 (pt) 2009-12-08
MX2007016049A (es) 2008-03-10
ZA200800746B (en) 2009-02-25
CN101238094A (zh) 2008-08-06
CR9665A (es) 2008-08-21
KR20080031910A (ko) 2008-04-11
WO2007000294A1 (en) 2007-01-04
RU2008103285A (ru) 2009-08-10
AR057416A1 (es) 2007-12-05
EP1902015A1 (en) 2008-03-26
ECSP088115A (es) 2008-02-20
TW200704632A (en) 2007-02-01

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