AR055671A1 - Proceso de fabricacion de derivados de quinazolina - Google Patents

Proceso de fabricacion de derivados de quinazolina

Info

Publication number
AR055671A1
AR055671A1 ARP060104320A ARP060104320A AR055671A1 AR 055671 A1 AR055671 A1 AR 055671A1 AR P060104320 A ARP060104320 A AR P060104320A AR P060104320 A ARP060104320 A AR P060104320A AR 055671 A1 AR055671 A1 AR 055671A1
Authority
AR
Argentina
Prior art keywords
compound
formula
manufacture
salt
quinazoline derivatives
Prior art date
Application number
ARP060104320A
Other languages
English (en)
Inventor
J Blixt
M Goolden
P Hogan
D Martin
F Montgomery
J Pittman
G Sependa
Cristopher Jhon Squire
N Wright
Z Patel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35395001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR055671(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR055671A1 publication Critical patent/AR055671A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procesos químicos para la fabricacion de determinados derivados de quinazolina, o sales de éstos aceptables para el uso farmacéutico. Procesos para a fabricacion de determinados intermediarios utiles en la fabricacion de los derivados de quinazolina, y procesos para la fabricacion de los derivados de quinazolina utilizando dichos intermediarios. en particular, la presente se relaciona con procesos químicos e intermediarios utiles en la fabricacion del compuesto 4-(4-bromo-2- fluoroanilino)-6-metoxi-7-(1-metilpiperidin-4-ilmetoxi)quinazolina. Reivindicacion 22: un proceso para la fabricacion de 7-(1-ter-butoxicarbonil)piperidin-4-ilmetoxi)-4-(4-bromo-2-fluoroanilino)-6-metoxiquinazolina, un compuesto de formula (10) a partir de 7-hidroxi-4-(4-bromo-2-fluoroanilino)-6-metoxiquinazolina, un compuesto de formula (9) caracterizado porque el proceso comprende los siguientes pasos: (l) hacer reaccionar el compuesto de formula (9) con un compuesto de formula (2) en presencia de una base apropiada., para proporcionar un compuesto de formula (10), o una sal de éste; y (m) aislar el compuesto de formula (10): (m-1) agregando agua y permitiendo que ocurra la cristalizacion del compuesto de formula (10), recolectando el compuesto de formula (10) y lavando el compuesto de formula (10) con agua, seguida por un solvente seleccionado entre acetato de etilo, acetato de butilo y acetonitrilo, a una temperatura en el rango de entre 25 y 55°C; o (m-2) agregando agua y un alcohol seleccionado entre metanol, etanol, isopropanol y n-propanol, y permitiendo que ocurra la cristalizacion del compuesto de formula (10), recolectando el compuesto de formula (10), y lavando el compuesto de formula (10) con una mezcla de agua y el alcohol seleccionado entre metanol, etanol, isopropanol y n-propanol, seguido por un solvente seleccionado entre acetato de etilo, acetato de butilo y acetonitrilo, a una temperatura en el rango de entre 25 y 55°C; y luego el compuesto de formula (10), obtenido en forma de base libre, puede convertirse en una forma de sal, y el compuesto de formula (10), obtenido en una forma de sal, puede convertirse en la base libre, o en forma de una sal alternativo, de ser necesario.
ARP060104320A 2005-09-30 2006-09-29 Proceso de fabricacion de derivados de quinazolina AR055671A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0519879.1A GB0519879D0 (en) 2005-09-30 2005-09-30 Chemical process

Publications (1)

Publication Number Publication Date
AR055671A1 true AR055671A1 (es) 2007-08-29

Family

ID=35395001

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104320A AR055671A1 (es) 2005-09-30 2006-09-29 Proceso de fabricacion de derivados de quinazolina

Country Status (32)

Country Link
US (8) US8163926B2 (es)
EP (2) EP1943240B1 (es)
JP (2) JP5213715B2 (es)
KR (1) KR101307641B1 (es)
CN (3) CN101277948B (es)
AR (1) AR055671A1 (es)
AT (2) ATE481399T1 (es)
AU (1) AU2006296367B2 (es)
BR (1) BRPI0616715A2 (es)
CA (2) CA2745829C (es)
CY (2) CY1110275T1 (es)
DE (2) DE602006017004D1 (es)
DK (2) DK1943240T3 (es)
ES (2) ES2350513T3 (es)
GB (1) GB0519879D0 (es)
HK (2) HK1122553A1 (es)
HR (2) HRP20100019T1 (es)
IL (2) IL190172A (es)
ME (2) ME01466B (es)
MY (2) MY149834A (es)
NO (1) NO342152B1 (es)
NZ (2) NZ566566A (es)
PL (2) PL2053048T3 (es)
PT (2) PT1943240E (es)
RS (2) RS51515B (es)
RU (1) RU2448102C2 (es)
SG (1) SG165416A1 (es)
SI (2) SI2053048T1 (es)
TW (2) TWI424991B (es)
UY (1) UY29824A1 (es)
WO (1) WO2007036713A2 (es)
ZA (1) ZA200802416B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268230B2 (en) * 2002-02-01 2007-09-11 Astrazeneca Ab Quinazoline compounds
GB0519879D0 (en) * 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
CL2007003158A1 (es) * 2006-11-02 2008-05-16 Astrazeneca Ab Procedimiento de preparacion de compuestos derivados de quinazolina o sus sales farmaceuticamente aceptables; compuestos intermediarios; procedimiento de preparacion.
EP2404595B1 (de) * 2011-09-01 2015-08-05 Symrise AG Verfahren zur Herstellung von Indanon-Derivaten
US9273001B2 (en) * 2012-08-15 2016-03-01 Glaxo Group Limited Chemical process
CN104098544A (zh) * 2013-04-07 2014-10-15 浙江九洲药物科技有限公司 一种凡德他尼的制备方法
CN106397401B (zh) * 2016-08-30 2018-11-13 山东罗欣药业集团股份有限公司 一种抗癌药物的晶体化合物及其制备方法

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WO1992006086A1 (en) 1990-10-01 1992-04-16 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
BR9205811A (pt) 1991-03-28 1994-06-28 Pfizer Derivados heterociclicos de aminas ciclicas
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AU685212B2 (en) * 1994-01-13 1998-01-15 Merck Sharp & Dohme Limited Gem-disubstituted azacyclic tachykinin antagonists
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GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
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Also Published As

Publication number Publication date
TW201018660A (en) 2010-05-16
JP2013063998A (ja) 2013-04-11
CN102503898B (zh) 2015-03-25
RS51263B (sr) 2010-12-31
US20220033377A1 (en) 2022-02-03
NZ593930A (en) 2013-02-22
ES2335435T3 (es) 2010-03-26
CY1110887T1 (el) 2015-06-10
RS51515B (en) 2011-06-30
CN102503898A (zh) 2012-06-20
US10344015B2 (en) 2019-07-09
PT1943240E (pt) 2010-01-11
DK1943240T3 (da) 2010-03-01
DK2053048T3 (da) 2010-11-29
DE602006010428D1 (de) 2009-12-24
HK1122553A1 (en) 2009-05-22
ES2350513T3 (es) 2011-01-24
NO342152B1 (no) 2018-04-03
CA2745829C (en) 2013-07-02
EP1943240A2 (en) 2008-07-16
ATE481399T1 (de) 2010-10-15
US20120095229A1 (en) 2012-04-19
WO2007036713A3 (en) 2007-06-14
US20180118716A1 (en) 2018-05-03
CN101277948B (zh) 2013-03-13
SI2053048T1 (sl) 2010-12-31
IL227574A (en) 2015-08-31
CA2745829A1 (en) 2007-04-05
US20240150317A1 (en) 2024-05-09
MY149834A (en) 2013-10-31
US8865899B2 (en) 2014-10-21
HRP20100620T1 (hr) 2010-12-31
KR101307641B1 (ko) 2013-09-12
UY29824A1 (es) 2007-04-30
US8163926B2 (en) 2012-04-24
CN101277948A (zh) 2008-10-01
IL190172A0 (en) 2008-08-07
DE602006017004D1 (de) 2010-10-28
TWI424991B (zh) 2014-02-01
HRP20100019T1 (hr) 2010-02-28
MY145540A (en) 2012-02-29
IL190172A (en) 2014-05-28
CN102503933B (zh) 2014-06-25
CN102503933A (zh) 2012-06-20
NO20081267L (no) 2008-04-30
KR20080049114A (ko) 2008-06-03
SG165416A1 (en) 2010-10-28
NZ566566A (en) 2011-08-26
EP2053048B1 (en) 2010-09-15
US20140378684A1 (en) 2014-12-25
TW200745036A (en) 2007-12-16
ZA200802416B (en) 2009-01-28
WO2007036713A2 (en) 2007-04-05
ATE448218T1 (de) 2009-11-15
ME01531B (me) 2014-04-20
GB0519879D0 (en) 2005-11-09
ME01466B (me) 2014-04-20
RU2448102C2 (ru) 2012-04-20
CA2624045A1 (en) 2007-04-05
PL1943240T3 (pl) 2010-04-30
US20190263782A1 (en) 2019-08-29
AU2006296367B2 (en) 2011-08-11
RU2008116573A (ru) 2009-11-10
PL2053048T3 (pl) 2011-03-31
CA2624045C (en) 2012-05-22
JP5213715B2 (ja) 2013-06-19
JP2009510039A (ja) 2009-03-12
SI1943240T1 (sl) 2010-02-26
TWI328580B (en) 2010-08-11
EP2053048A1 (en) 2009-04-29
EP1943240B1 (en) 2009-11-11
US20090203905A1 (en) 2009-08-13
US9815816B2 (en) 2017-11-14
PT2053048E (pt) 2010-11-10
EP2053048B8 (en) 2011-09-21
BRPI0616715A2 (pt) 2011-06-28
CY1110275T1 (el) 2015-01-14
HK1130478A1 (en) 2009-12-31
US20160185754A1 (en) 2016-06-30
AU2006296367A1 (en) 2007-04-05
JP5654546B2 (ja) 2015-01-14

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