PE20050954A1 - Proceso para la preparacion de compuestos de 1-[ciano(fenil)metil]-ciclohexanol - Google Patents

Proceso para la preparacion de compuestos de 1-[ciano(fenil)metil]-ciclohexanol

Info

Publication number
PE20050954A1
PE20050954A1 PE2004000934A PE2004000934A PE20050954A1 PE 20050954 A1 PE20050954 A1 PE 20050954A1 PE 2004000934 A PE2004000934 A PE 2004000934A PE 2004000934 A PE2004000934 A PE 2004000934A PE 20050954 A1 PE20050954 A1 PE 20050954A1
Authority
PE
Peru
Prior art keywords
cyane
cyclohexanol
phenyl
preparation
methyl
Prior art date
Application number
PE2004000934A
Other languages
English (en)
Inventor
Hans Rudolf Marti
Huldreich Trafelet
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34398335&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20050954(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20050954A1 publication Critical patent/PE20050954A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA PREPARACION DE COMPUESTOS 1-[CIANO(FENIL)METIL]-CICLOHEXANOL DE FORMULA (I), EN DONDE R1 ES H O ALCOXI(C1-C4); R2 ES H, ALQUILO(C1-C4) O ALCOXI(C1-C4) Y EN ESPECIAL DEL COMPUESTO 1-[CIANO(4-METOXIFENIL)-METIL]CICLOHEXANOL, EL CUAL ES UN AGENTE INTERMEDIARIO PARA LA PREPARACION DE VENLAFAXINA (ANTIDEPRESIVO). LA REACCION SE LLEVA A CABO HACIENDO REACCIONAR UN COMPUESTO DE FORMULA (II): CIANOMETIL-FENIL(R1 Y R2 SUSTITUIDOS), CON CICLOHEXANONA EN PRESENCIA DE UN CATALIZADOR SELECCIONADOS DEL GRUPO DE LOS ALCOHOLATOS DE: METALES ALCALINOS, METALICOS DE TIERRA, DE ALUMINO E HIDROXIDOS DE AMINO TETRASUSTITUIDOS TALES COMO ALCOHOLATO DE ALUMINIO, DE ETANOL, DE TERC-BUTILATO DE ALUMINIO, HIDROXIDO DE TETRABUTILAMINO, ENTRE OTROS; LA REACCION PUEDE REALIZARSE EN PRESENCIA O NO, DE UN DISOLVENTE INERTE COMO: PENTANO, HEXANO, HEPTANO, BENCENO, ENTRE OTROS. LA TEMPERATURA ADECUADA DE REACCION ES DE MENOS DE 30 °C, Y EL PRODUCTO PUEDE ENTONCES AISLARSE DESPUES DE ANADIRSE EL DISOLVENTE, SI ES NECESARIO Y OPTATIVAMENTE PURIFICARSE
PE2004000934A 2003-10-02 2004-09-30 Proceso para la preparacion de compuestos de 1-[ciano(fenil)metil]-ciclohexanol PE20050954A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH16722003 2003-10-02

Publications (1)

Publication Number Publication Date
PE20050954A1 true PE20050954A1 (es) 2005-12-20

Family

ID=34398335

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000934A PE20050954A1 (es) 2003-10-02 2004-09-30 Proceso para la preparacion de compuestos de 1-[ciano(fenil)metil]-ciclohexanol

Country Status (21)

Country Link
US (1) US20050080288A1 (es)
EP (1) EP1667961A1 (es)
JP (1) JP2007507517A (es)
KR (1) KR20060096427A (es)
CN (1) CN1860099A (es)
AR (1) AR046045A1 (es)
AU (1) AU2004279806A1 (es)
BR (1) BRPI0414969A (es)
CA (1) CA2539638A1 (es)
CO (1) CO5690633A2 (es)
CR (1) CR8295A (es)
EC (1) ECSP066469A (es)
IL (1) IL174337A0 (es)
MX (1) MXPA06003460A (es)
NO (1) NO20061442L (es)
PE (1) PE20050954A1 (es)
RU (1) RU2006114766A (es)
SG (1) SG146650A1 (es)
TW (1) TW200523258A (es)
WO (1) WO2005035483A1 (es)
ZA (1) ZA200602681B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060067613A (ko) * 2004-12-15 2006-06-20 에스케이 주식회사 1-[시아노-(파라-메톡시페닐)메틸]시클로헥사놀의 제조방법
JP2009511641A (ja) * 2005-10-19 2009-03-19 テバ ファーマシューティカル インダストリーズ リミティド 高純度１−〔２−ジメチルアミノ−（４−メトキシフェニル）エチル〕シクロヘキサノール塩酸塩の調製方法
EP2043999A2 (en) * 2005-11-30 2009-04-08 Aarti Healthcare Limited A process for the preparation of venlafaxine hydrochloride

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56324B1 (en) * 1982-12-13 1991-06-19 American Home Prod Phenethylamine derivatives and intermediates therefor
GB8902209D0 (en) * 1989-02-01 1989-03-22 Wyeth John And Brother Limited Preparation of cyclohexanol derivatives and novel thioamide intermediates
US5457222A (en) * 1991-07-25 1995-10-10 Kao Corporation Process for producing nitrile
CN1225356A (zh) * 1998-12-15 1999-08-11 华东理工大学 1－[2－氨基－1－(对甲氧苯基)乙基]环己醇的合成方法
EP1238967B1 (en) * 2001-02-28 2005-04-27 Council of Scientific and Industrial Research A process for the preparation of 1-(cyano(aryl)methyl) cyclohexanol
KR20030000217A (ko) * 2001-06-22 2003-01-06 와이어쓰 시클로헥사놀 유도체의 제조방법
WO2003050074A1 (en) * 2001-12-13 2003-06-19 Cadila Healthcare Limited Manufacture of venlafaxine hydrochloride and crystalline polymorphs thereof

Also Published As

Publication number Publication date
TW200523258A (en) 2005-07-16
ECSP066469A (es) 2006-09-18
IL174337A0 (en) 2006-08-01
EP1667961A1 (en) 2006-06-14
RU2006114766A (ru) 2007-11-20
SG146650A1 (en) 2008-10-30
BRPI0414969A (pt) 2006-11-07
WO2005035483A1 (en) 2005-04-21
CO5690633A2 (es) 2006-10-31
CN1860099A (zh) 2006-11-08
CA2539638A1 (en) 2005-04-21
AU2004279806A1 (en) 2005-04-21
ZA200602681B (en) 2010-09-29
KR20060096427A (ko) 2006-09-11
JP2007507517A (ja) 2007-03-29
NO20061442L (no) 2006-04-27
MXPA06003460A (es) 2006-06-05
US20050080288A1 (en) 2005-04-14
CR8295A (es) 2006-10-06
AR046045A1 (es) 2005-11-23

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