AR063042A1 - Un proceso para preparar aminoalquilfenilcarbamatos y compuestos intermedios para dicho proceso - Google Patents
Un proceso para preparar aminoalquilfenilcarbamatos y compuestos intermedios para dicho procesoInfo
- Publication number
- AR063042A1 AR063042A1 ARP070104300A ARP070104300A AR063042A1 AR 063042 A1 AR063042 A1 AR 063042A1 AR P070104300 A ARP070104300 A AR P070104300A AR P070104300 A ARP070104300 A AR P070104300A AR 063042 A1 AR063042 A1 AR 063042A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- intermediate compounds
- alkyl phenyl
- amino alkyl
- phenyl carbamates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente se refiere a un proceso para preparar el compuesto de formula general (1), o una sal de adicion ácida, donde la línea de trazos indica un enlace carbono-carbono unido al carbono asimétrico, proceso que comprende las etapas de a) la reaccion del compuesto de formula (2) donde la línea de trazos tiene el mismo significado, con bis(p-nitrofenil) carbonato de la formula (IX) preferentemente a la temperatura entre -20 y 50°C y en un solvente inerte, seguido por b) la reaccion del compuesto intermedio así formado de la formula (VII-I) con etilmetilamina de formula (III), preferentemente a la temperatura entre -20° y 50° C en un solvente inerte, y a nuevos compuestos y su uso en la síntesis de rivastigmina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82761306P | 2006-09-29 | 2006-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063042A1 true AR063042A1 (es) | 2008-12-23 |
Family
ID=38751577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070104300A AR063042A1 (es) | 2006-09-29 | 2007-09-28 | Un proceso para preparar aminoalquilfenilcarbamatos y compuestos intermedios para dicho proceso |
Country Status (7)
Country | Link |
---|---|
US (1) | US7531684B2 (es) |
EP (1) | EP2076485B1 (es) |
AR (1) | AR063042A1 (es) |
AT (1) | ATE504560T1 (es) |
CL (1) | CL2007002781A1 (es) |
DE (1) | DE602007013791D1 (es) |
WO (2) | WO2008037433A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8420846B2 (en) | 2008-08-25 | 2013-04-16 | Jubilant Life Sciences Limited | Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates |
WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
HU201906B (en) | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
US20050096367A1 (en) * | 2002-05-28 | 2005-05-05 | Yoshiro Kitahara | Pharmaceutical composition for suppression of the expression of ATP citrate lyase and use thereof |
US7385076B2 (en) | 2002-05-31 | 2008-06-10 | Sun Pharmaceutical Industries Limited | Process for the preparation of phenylcarbamates |
CZ20023555A3 (cs) | 2002-10-24 | 2004-01-14 | Léčiva, A.S. | Způsob výroby (-)-(S)-3-[1-(dimethylamino)ethyl]fenyl-N-ethyl-N-methylkarbamátu |
CN1206210C (zh) | 2003-07-31 | 2005-06-15 | 上海三维制药有限公司 | 乙基甲基氨甲酸3-[(1s)-1-(二甲氨基)乙基]苯酯盐的制备方法 |
CN1898201A (zh) | 2003-10-21 | 2007-01-17 | 森蒂有限公司 | 可抑制胆碱酯酶和释放药理学活性试剂的氨基甲酸酯 |
JP4954886B2 (ja) * | 2004-11-08 | 2012-06-20 | エムキュア ファーマシューティカルズ リミテッド | (s)−3−[(1−ジメチルアミノ)エチル]−フェニル−n−エチル−n−メチル−カルバミン酸の効率的製造方法 |
US7767843B2 (en) * | 2006-03-02 | 2010-08-03 | Apotex Pharmachem Inc. | Process for the preparation of phenylcarbamates |
-
2007
- 2007-09-20 WO PCT/EP2007/008339 patent/WO2008037433A1/en active Application Filing
- 2007-09-27 WO PCT/EP2007/009994 patent/WO2008037503A2/en active Application Filing
- 2007-09-27 DE DE602007013791T patent/DE602007013791D1/de active Active
- 2007-09-27 EP EP07846670A patent/EP2076485B1/en not_active Not-in-force
- 2007-09-27 CL CL200702781A patent/CL2007002781A1/es unknown
- 2007-09-27 AT AT07846670T patent/ATE504560T1/de not_active IP Right Cessation
- 2007-09-28 AR ARP070104300A patent/AR063042A1/es unknown
- 2007-09-28 US US11/863,779 patent/US7531684B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2076485A2 (en) | 2009-07-08 |
WO2008037503A2 (en) | 2008-04-03 |
CL2007002781A1 (es) | 2008-04-25 |
WO2008037503A3 (en) | 2008-05-22 |
DE602007013791D1 (de) | 2011-05-19 |
WO2008037433A1 (en) | 2008-04-03 |
US7531684B2 (en) | 2009-05-12 |
US20080154057A1 (en) | 2008-06-26 |
ATE504560T1 (de) | 2011-04-15 |
EP2076485B1 (en) | 2011-04-06 |
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Legal Events
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