GT200800154A - N-sulfonilacion selectiva de alcoholes 2-amino trifluoroalquilo sustituidos - Google Patents

N-sulfonilacion selectiva de alcoholes 2-amino trifluoroalquilo sustituidos

Info

Publication number
GT200800154A
GT200800154A GT200800154A GT200800154A GT200800154A GT 200800154 A GT200800154 A GT 200800154A GT 200800154 A GT200800154 A GT 200800154A GT 200800154 A GT200800154 A GT 200800154A GT 200800154 A GT200800154 A GT 200800154A
Authority
GT
Guatemala
Prior art keywords
trifluoroalquilo
sulfonilacion
selectiva
alcoholes
substitutes
Prior art date
Application number
GT200800154A
Other languages
English (en)
Inventor
Anita Wai-Yin Chan
Jianxin Ren
Mousumi Ghosh
Panolil Raveendranath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200800154A publication Critical patent/GT200800154A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PROVEEN PROCEDIMIENTOS PARA LA PREPARACIÓN DE DERIVADOS N-(2-HIDROXIALQUILO) HETEROARENO - Y BENCENSULFONAMIDA TRIFLUOROALQUILO SUSTITUIDOS DE FÓRMULA (I) O FÓRMULA (II) (EN DONDE LAS VARIABLES SE DEFINEN EN LAS REIVINDICACIONES) Y COMPRENDEN HACER REACCIONAR UN AMINO ALCOHOL SUSTITUIDO CON TRIFLUOROALQUILO, UN CLORURO DE SULFONILO Y UN SISTEMA DE BASE/SOLVENTE SELECCIONADO DEL GRUPO QUE CONSISTE EN (A) 4-METILMORFOLINA/ACETATO DE ISOPROPILO, (B) BASE DE HÜNIG/TETRAHIDROFURANO, (C) 4-METILMORFOLINA/ACETONITRILO (D) 4-METILMORFOLINA/PROPIONITRILO Y (E) 4-METILMORFOLINA/TOLUENO.
GT200800154A 2006-02-17 2008-08-12 N-sulfonilacion selectiva de alcoholes 2-amino trifluoroalquilo sustituidos GT200800154A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77430006P 2006-02-17 2006-02-17

Publications (1)

Publication Number Publication Date
GT200800154A true GT200800154A (es) 2008-10-21

Family

ID=38124142

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200800154A GT200800154A (es) 2006-02-17 2008-08-12 N-sulfonilacion selectiva de alcoholes 2-amino trifluoroalquilo sustituidos

Country Status (18)

Country Link
US (1) US7838550B2 (es)
EP (1) EP1984347A1 (es)
JP (1) JP2009527476A (es)
KR (1) KR20080094685A (es)
CN (1) CN101384579A (es)
AR (1) AR059517A1 (es)
AU (1) AU2007217966A1 (es)
BR (1) BRPI0707742A2 (es)
CA (1) CA2637615A1 (es)
CR (1) CR10158A (es)
EC (1) ECSP088684A (es)
GT (1) GT200800154A (es)
IL (1) IL192929A0 (es)
NO (1) NO20083488L (es)
PE (1) PE20080109A1 (es)
RU (1) RU2008131051A (es)
TW (1) TW200732295A (es)
WO (1) WO2007098030A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE430727T1 (de) 2001-12-20 2009-05-15 Bristol Myers Squibb Co Alpha-(n-sulfonamid)acetamidderivate als beta- amyloidinhibitoren
CN101274926A (zh) * 2003-03-31 2008-10-01 惠氏公司 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物
US7476762B2 (en) * 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
US7550629B2 (en) * 2006-04-21 2009-06-23 Wyeth Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
CA2693959A1 (en) * 2007-07-16 2009-01-22 Wyeth Inhibitors of beta amyloid production
TW200911778A (en) * 2007-07-16 2009-03-16 Wyeth Corp Process for the preparation of trifluoroalkyl-phenyl and heterocyclic sulfonamides
WO2009012203A1 (en) * 2007-07-16 2009-01-22 Wyeth Processes and intermediates for the preparation of heterocyclic sulfonamide compounds
US8093276B2 (en) * 2007-10-31 2012-01-10 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US8084477B2 (en) 2007-10-31 2011-12-27 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
CN102088855A (zh) * 2008-05-08 2011-06-08 百时美施贵宝公司 2-芳基甘氨酰胺衍生物
US8044077B2 (en) 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
US20110071199A1 (en) * 2009-03-20 2011-03-24 Bristol-Myers Squibb Company Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
TW201043269A (en) * 2009-04-14 2010-12-16 Bristol Myers Squibb Co Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound
US8252821B2 (en) 2009-04-14 2012-08-28 Bristol-Myers Squibb Company Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100266467B1 (ko) 1995-09-27 2000-10-02 우에노 도시오 설폰아미드 유도체
JPH09241262A (ja) 1996-03-08 1997-09-16 Kao Corp ３−オキサ−２，７−ジアザビシクロ〔３．３．０〕オクタン誘導体
US5962231A (en) * 1997-09-30 1999-10-05 Incyte Pharmaceuticals, Inc. Human glutathione-S-transferase
PT1049695E (pt) * 1997-11-12 2002-07-31 Bayer Ag Imidazotriazinonas 2-fenil substituidas enquanto inibidores de fosfodiesterase
JPH11343279A (ja) 1998-03-16 1999-12-14 Shionogi & Co Ltd スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤
GB9805520D0 (en) * 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
DE19827640A1 (de) * 1998-06-20 1999-12-23 Bayer Ag 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
AU2841801A (en) * 1999-12-24 2001-07-09 Bayer Aktiengesellschaft Triazolotriazinones and the use thereof
KR20020062770A (ko) * 1999-12-24 2002-07-29 바이엘 악티엔게젤샤프트 이미다조 1,3,5 트리아지논 및 그의 용도
NZ526213A (en) * 2000-12-13 2005-05-27 Wyeth Corp Heterocyclic sulfonamide inhibitors of beta amyloid production
US6657070B2 (en) * 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
BR0214863A (pt) * 2001-12-11 2004-12-14 Wyeth Corp Processo para a sìntese de beta-aminoálcoois quiralmente puros
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
US7288547B2 (en) * 2002-03-11 2007-10-30 Schering Ag CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents
AU2003212282A1 (en) 2002-03-11 2003-09-22 Schering Aktiengesellschaft Cdk inhibiting 2-heteroaryl pyrimidine, the production thereof, and use thereof as a medicament
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
CA2486581A1 (en) * 2002-06-11 2003-12-18 Wyeth Substituted phenylsulfonamide inhibitors of beta amyloid production
WO2004078731A1 (fr) 2003-03-06 2004-09-16 'chemical Diversity Research Institute', Ltd. Acides quinoline-carboxyliques et leurs derives et bibliotheque focalisee
CN101274926A (zh) * 2003-03-31 2008-10-01 惠氏公司 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物
WO2005073198A1 (en) * 2004-01-16 2005-08-11 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
US7687666B2 (en) * 2006-02-17 2010-03-30 Wyeth Methods for preparing sulfonamide substituted alcohols and intermediates thereof

Also Published As

Publication number Publication date
AU2007217966A1 (en) 2007-08-30
TW200732295A (en) 2007-09-01
CN101384579A (zh) 2009-03-11
CA2637615A1 (en) 2007-08-30
US20070197800A1 (en) 2007-08-23
KR20080094685A (ko) 2008-10-23
ECSP088684A (es) 2008-09-29
EP1984347A1 (en) 2008-10-29
IL192929A0 (en) 2009-02-11
AR059517A1 (es) 2008-04-09
WO2007098030A1 (en) 2007-08-30
BRPI0707742A2 (pt) 2011-05-10
PE20080109A1 (es) 2008-04-01
WO2007098030A8 (en) 2007-10-25
NO20083488L (no) 2008-09-05
RU2008131051A (ru) 2010-03-27
US7838550B2 (en) 2010-11-23
JP2009527476A (ja) 2009-07-30
CR10158A (es) 2008-10-29

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