PE20070118A1 - Compuestos macrolidos inhibidores del virus de la hepatitis c - Google Patents
Compuestos macrolidos inhibidores del virus de la hepatitis cInfo
- Publication number
- PE20070118A1 PE20070118A1 PE2006000682A PE2006000682A PE20070118A1 PE 20070118 A1 PE20070118 A1 PE 20070118A1 PE 2006000682 A PE2006000682 A PE 2006000682A PE 2006000682 A PE2006000682 A PE 2006000682A PE 20070118 A1 PE20070118 A1 PE 20070118A1
- Authority
- PE
- Peru
- Prior art keywords
- alpha
- amino acid
- residue
- ring
- positions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO UNIDO A LA CICLOFILINA, TAL COMO UN MACROLIDO DE SANGLIFERINA DE FORMULA S--L--M, DONDE S ES ALQUILO C1-C10 DE CADENA RAMIFICADA O LINEAL; L ES UN ENLAZADOR QUE COMPRENDE UNA SECUENCIA LINEAL C6-C11; M ES UN ANILLO MACROCICLICO EN DONDE LAS POSICIONES 2 A 6 DE DICHO ANILLO MACROCICLICO SON PROPORCIONADAS POR UN RESIDUO DE ACIDO PIPERIDAZINIL CARBOXILICO INSUSTITUIDO; LAS POSICIONES 7 A 9 DE DICHO MACROCICLICO SON PROPORCIONADAS POR UN RESIDUO DE ALFA-AMINOACIDO AROMATICO, DONDE EL CARBOXI DEL RESIDUO ALFA-AMINOACIDO AROMATICO OCUPA LA POSICION 7 DEL MENCIONADO ANILLO MACROCICLICO, Y EL COMPONENTE ALFA-AMINO DE DICHO RESIDUO OCUPA LA POSICION 9 DEL MACROCICLICO; LAS POSICIONES 10 A 12 DEL MACROCICLICO SON PROPORCIONADAS POR UN RESIDUO DE ALFA AMINOACIDO ALIFATICO, EN DONDE EL COMPONENTE CARBOXI DEL RESIDUOALFA-AMINOACIDO ALIFATICO OCUPA LA POSICION 10 DEL ANILLO MACROCICLICO Y EL COMPONENTE ALFA-AMINO ALIFATICO OCUPA LA POSICION 12 DEL MACROCICLICO. SON COMPUESTOS PREFERIDOS W; Y; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE LA HEPATITIS C
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69149705P | 2005-06-17 | 2005-06-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070118A1 true PE20070118A1 (es) | 2007-02-23 |
Family
ID=37075234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000682A PE20070118A1 (es) | 2005-06-17 | 2006-06-16 | Compuestos macrolidos inhibidores del virus de la hepatitis c |
Country Status (21)
Country | Link |
---|---|
US (1) | US20090221598A1 (es) |
EP (1) | EP1893211B1 (es) |
JP (1) | JP2008546708A (es) |
KR (1) | KR20080033274A (es) |
CN (1) | CN101242842A (es) |
AR (1) | AR054778A1 (es) |
AT (1) | ATE524183T1 (es) |
AU (1) | AU2006259348B2 (es) |
BR (1) | BRPI0613142A2 (es) |
CA (1) | CA2611151A1 (es) |
EC (1) | ECSP078029A (es) |
GT (1) | GT200600262A (es) |
MA (1) | MA29600B1 (es) |
MX (1) | MX2007016068A (es) |
NO (1) | NO20080351L (es) |
PE (1) | PE20070118A1 (es) |
RU (1) | RU2427372C2 (es) |
TN (1) | TNSN07477A1 (es) |
TW (1) | TW200740438A (es) |
WO (1) | WO2006138507A1 (es) |
ZA (1) | ZA200710551B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102224242B (zh) * | 2008-09-24 | 2014-09-24 | 中国科学院上海有机化学研究所 | 新基因簇 |
WO2011011632A1 (en) * | 2009-07-22 | 2011-01-27 | Tufts University | Methods and compositions for modulating membrane potential to influence cell behavior |
US20110117055A1 (en) | 2009-11-19 | 2011-05-19 | Macdonald James E | Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds |
EP2533784B1 (en) | 2010-02-09 | 2015-04-22 | Neurovive Pharmaceutical AB | Sanglifehrin based compounds |
WO2011098805A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
WO2011098808A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
GB201008123D0 (en) | 2010-05-17 | 2010-06-30 | Biotica Tech Ltd | Novel compounds |
UY33775A (es) * | 2010-12-10 | 2012-07-31 | Gilead Sciences Inc | Inhibidores macrocíclicos de virus flaviviridae, composiciones farmacéuticas que los comprenden y sus usos |
EP3427737A1 (en) | 2010-12-20 | 2019-01-16 | NeuroVive Pharmaceutical AB | Sanglifehrin derivatives and methods for their production |
JO3063B1 (ar) | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
WO2012145427A1 (en) * | 2011-04-18 | 2012-10-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat cancer using cyclosporine and cyclosporine derivatives |
GB201118334D0 (en) | 2011-10-24 | 2011-12-07 | Biotica Tech Ltd | Novel dosage form |
AR091279A1 (es) * | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
JP6209601B2 (ja) * | 2012-06-08 | 2017-10-04 | ギリアード サイエンシーズ, インコーポレイテッド | フラビウイルス科ウイルスの大環状阻害剤 |
SI2859009T1 (sl) | 2012-06-08 | 2017-12-29 | Gilead Sciences, Inc. | Makrociklični inhibitorji flaviviridae virusov |
Family Cites Families (38)
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US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
JP2514950B2 (ja) | 1986-03-10 | 1996-07-10 | エフ・ホフマン―ラ ロシユ アーゲー | 化学修飾蛋白質,その製造法および中間体 |
GB2222770B (en) | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
DE69132332T2 (de) | 1990-04-06 | 2000-11-30 | Genelabs Tech Inc | Hepatitis c-virus-epitope |
US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
GB9318612D0 (en) | 1993-09-08 | 1993-10-27 | Sandoz Ltd | An assay |
NZ276943A (en) | 1993-11-10 | 1998-02-26 | Schering Corp Substituted For | Alpha-interferon conjugated to a non-antigenic polymer (preferably a polyalkylene oxide) and its preparation |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
AR006514A1 (es) | 1995-07-04 | 1999-09-08 | Sandoz Ag | Un macrolido, sus usos, un proceso para producirlo, un aislado biologicamente puro capaz de producirlo, y una composicion farmaceutica quelo comprende |
US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
US5990276A (en) | 1996-05-10 | 1999-11-23 | Schering Corporation | Synthetic inhibitors of hepatitis C virus NS3 protease |
NZ335276A (en) | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
US6004933A (en) | 1997-04-25 | 1999-12-21 | Cortech Inc. | Cysteine protease inhibitors |
ES2234144T3 (es) | 1997-08-11 | 2005-06-16 | Boehringer Ingelheim (Canada) Ltd. | Analogos de peptidos inhibidores de la hepatitis c. |
GB9806815D0 (en) | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
GB9811854D0 (en) * | 1998-06-02 | 1998-07-29 | Ciba Geigy Ag | Organic compounds |
US6444652B1 (en) | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
YU92202A (sh) | 2000-05-26 | 2006-01-16 | Idenix (Cayman) Limited | Metode i smeše za lečenje flavi virusa i pesti virusa |
ES2227203T3 (es) | 2000-05-26 | 2005-04-01 | Idenix (Cayman) Limited | Metodos para tratar la infeccion por el virus de la hepatitis delta con beta-1-2'-desoxinucleosidos. |
MY141594A (en) | 2000-06-15 | 2010-05-14 | Novirio Pharmaceuticals Ltd | 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES |
WO2002008251A2 (en) | 2000-07-21 | 2002-01-31 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
HUP0303358A3 (en) | 2000-07-21 | 2005-10-28 | Schering Corp | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus and pharmaceutical compositions containing them |
AU2001255070A1 (en) | 2000-08-28 | 2002-03-13 | Jin-Sub Kim | Generator of two-wheeled vehicle and lighting system thereby |
ES2263687T3 (es) | 2000-11-20 | 2006-12-16 | Bristol-Myers Squibb Company | Inhibidores tripeptidicos de la hepatitis c. |
EP1343807B1 (en) | 2000-12-12 | 2009-04-29 | Schering Corporation | Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus |
AU2002230764A1 (en) | 2000-12-13 | 2002-06-24 | Bristol-Myers Squibb Pharma Company | Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors |
WO2002048116A2 (en) | 2000-12-13 | 2002-06-20 | Bristol-Myers Squibb Pharma Company | Inhibitors of hepatitis c virus ns3 protease |
AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
JP4892486B2 (ja) * | 2004-10-01 | 2012-03-07 | デビオファーム ソシエテ アノニム | C型肝炎感染の治療のための[d−meala]3−[etval]4−シクロスポリンの使用、及び当該[d−meala]3−[etval]4−シクロスポリンを含む医薬組成物 |
US7897565B2 (en) * | 2004-12-23 | 2011-03-01 | Novartis Ag | Compositions for HCV treatment |
-
2006
- 2006-06-15 EP EP06784962A patent/EP1893211B1/en not_active Not-in-force
- 2006-06-15 JP JP2008517117A patent/JP2008546708A/ja active Pending
- 2006-06-15 CN CNA2006800297685A patent/CN101242842A/zh active Pending
- 2006-06-15 AR ARP060102543A patent/AR054778A1/es unknown
- 2006-06-15 BR BRPI0613142-5A patent/BRPI0613142A2/pt not_active IP Right Cessation
- 2006-06-15 RU RU2008100587/15A patent/RU2427372C2/ru not_active IP Right Cessation
- 2006-06-15 US US11/917,781 patent/US20090221598A1/en not_active Abandoned
- 2006-06-15 AT AT06784962T patent/ATE524183T1/de not_active IP Right Cessation
- 2006-06-15 KR KR1020087001271A patent/KR20080033274A/ko not_active Application Discontinuation
- 2006-06-15 MX MX2007016068A patent/MX2007016068A/es not_active Application Discontinuation
- 2006-06-15 WO PCT/US2006/023394 patent/WO2006138507A1/en active Application Filing
- 2006-06-15 CA CA002611151A patent/CA2611151A1/en not_active Abandoned
- 2006-06-15 AU AU2006259348A patent/AU2006259348B2/en not_active Ceased
- 2006-06-16 GT GT200600262A patent/GT200600262A/es unknown
- 2006-06-16 TW TW095121787A patent/TW200740438A/zh unknown
- 2006-06-16 PE PE2006000682A patent/PE20070118A1/es not_active Application Discontinuation
-
2007
- 2007-12-04 ZA ZA200710551A patent/ZA200710551B/xx unknown
- 2007-12-14 TN TNP2007000477A patent/TNSN07477A1/en unknown
- 2007-12-17 EC EC2007008029A patent/ECSP078029A/es unknown
- 2007-12-26 MA MA30507A patent/MA29600B1/fr unknown
-
2008
- 2008-01-16 NO NO20080351A patent/NO20080351L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA29600B1 (fr) | 2008-07-01 |
AU2006259348A1 (en) | 2006-12-28 |
KR20080033274A (ko) | 2008-04-16 |
RU2427372C2 (ru) | 2011-08-27 |
AR054778A1 (es) | 2007-07-18 |
EP1893211A1 (en) | 2008-03-05 |
GT200600262A (es) | 2007-03-28 |
US20090221598A1 (en) | 2009-09-03 |
ECSP078029A (es) | 2008-01-23 |
CA2611151A1 (en) | 2006-12-28 |
EP1893211B1 (en) | 2011-09-14 |
NO20080351L (no) | 2008-03-14 |
ATE524183T1 (de) | 2011-09-15 |
BRPI0613142A2 (pt) | 2010-12-21 |
RU2008100587A (ru) | 2009-07-27 |
ZA200710551B (en) | 2008-11-26 |
WO2006138507A1 (en) | 2006-12-28 |
TNSN07477A1 (en) | 2009-03-17 |
AU2006259348B2 (en) | 2010-07-22 |
TW200740438A (en) | 2007-11-01 |
JP2008546708A (ja) | 2008-12-25 |
MX2007016068A (es) | 2008-03-10 |
CN101242842A (zh) | 2008-08-13 |
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