PE20060430A1 - Derivados de pirrolopiridina como moduladores de los receptores cannabinoides - Google Patents
Derivados de pirrolopiridina como moduladores de los receptores cannabinoidesInfo
- Publication number
- PE20060430A1 PE20060430A1 PE2005000651A PE2005000651A PE20060430A1 PE 20060430 A1 PE20060430 A1 PE 20060430A1 PE 2005000651 A PE2005000651 A PE 2005000651A PE 2005000651 A PE2005000651 A PE 2005000651A PE 20060430 A1 PE20060430 A1 PE 20060430A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- optionally substituted
- modulators
- pyrrolo
- heterocycle
- Prior art date
Links
- 102000018208 Cannabinoid Receptor Human genes 0.000 title 1
- 108050007331 Cannabinoid receptor Proteins 0.000 title 1
- 150000005255 pyrrolopyridines Chemical class 0.000 title 1
- -1 PIPERIDINYL Chemical class 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- XWIYUCRMWCHYJR-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyridine Chemical compound C1=CC=C2NC=CC2=N1 XWIYUCRMWCHYJR-UHFFFAOYSA-N 0.000 abstract 1
- PNPCRKVUWYDDST-UHFFFAOYSA-N 3-chloroaniline Chemical compound NC1=CC=CC(Cl)=C1 PNPCRKVUWYDDST-UHFFFAOYSA-N 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 229930003827 cannabinoid Natural products 0.000 abstract 1
- 239000003557 cannabinoid Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0412908A GB0412908D0 (en) | 2004-06-09 | 2004-06-09 | Compounds |
| GB0424950A GB0424950D0 (en) | 2004-11-11 | 2004-11-11 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060430A1 true PE20060430A1 (es) | 2006-05-25 |
Family
ID=34969264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000651A PE20060430A1 (es) | 2004-06-09 | 2005-06-07 | Derivados de pirrolopiridina como moduladores de los receptores cannabinoides |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7589206B2 (enExample) |
| EP (1) | EP1753764B1 (enExample) |
| JP (1) | JP2008501758A (enExample) |
| KR (1) | KR20070034049A (enExample) |
| AR (1) | AR050158A1 (enExample) |
| AT (1) | ATE412651T1 (enExample) |
| AU (1) | AU2005251913A1 (enExample) |
| BR (1) | BRPI0511874A (enExample) |
| CA (1) | CA2569887A1 (enExample) |
| DE (1) | DE602005010698D1 (enExample) |
| DK (1) | DK1753764T3 (enExample) |
| ES (1) | ES2317244T3 (enExample) |
| HR (1) | HRP20090034T3 (enExample) |
| IL (1) | IL179603A0 (enExample) |
| MA (1) | MA28686B1 (enExample) |
| MX (1) | MXPA06014471A (enExample) |
| NO (1) | NO20070067L (enExample) |
| PE (1) | PE20060430A1 (enExample) |
| PL (1) | PL1753764T3 (enExample) |
| PT (1) | PT1753764E (enExample) |
| RU (1) | RU2006147278A (enExample) |
| SI (1) | SI1753764T1 (enExample) |
| TW (1) | TW200611695A (enExample) |
| UY (1) | UY28945A1 (enExample) |
| WO (1) | WO2005121140A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ544331A (en) | 2003-07-22 | 2010-03-26 | Arena Pharm Inc | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
| DK1753764T3 (da) | 2004-06-09 | 2009-02-16 | Glaxo Group Ltd | Pyrrolopyridin-derivater |
| JP4977465B2 (ja) * | 2004-07-28 | 2012-07-18 | 武田薬品工業株式会社 | ピロロ［２，３−ｃ］ピリジン化合物、その製造方法および用途 |
| DK1784404T3 (da) * | 2004-09-03 | 2012-02-13 | Yuhan Corp | Pyrrolo[2,3-c]pyridinderivater samt fremgangsmåder til deres fremstilling |
| BRPI0614272A2 (pt) * | 2005-08-09 | 2011-03-22 | Glaxo Group Ltd | derivados de imidazopiridinas como ligantes de receptores canabinóides |
| GB0516379D0 (en) * | 2005-08-09 | 2005-09-14 | Glaxo Group Ltd | Compounds |
| JP2009536613A (ja) * | 2006-04-07 | 2009-10-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節する化合物 |
| EP2120950B1 (en) * | 2007-03-21 | 2012-07-04 | Glaxo Group Limited | Use of quinoline derivatives in the treatment of pain |
| GB0705803D0 (en) * | 2007-03-28 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
| EP2254564A1 (en) | 2007-12-12 | 2010-12-01 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| CA2757188A1 (en) | 2009-03-30 | 2010-10-07 | Astellas Pharma Inc. | Pyrimidine compound |
| TW201200518A (en) * | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| WO2012014963A1 (ja) * | 2010-07-29 | 2012-02-02 | アステラス製薬株式会社 | 縮環ピリジン化合物 |
| JP6326563B2 (ja) * | 2012-03-19 | 2018-05-23 | アリエル−ユニバーシティー リサーチ アンド デベロップメント カンパニー リミテッド | β−カリオフィレンとＣＢ２受容体アゴニストを用いた精神病の治療 |
| EP3483167A1 (en) | 2013-06-26 | 2019-05-15 | AbbVie Inc. | Primary carboxamides as btk inhibitors |
| JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
| CN108472285A (zh) | 2015-07-15 | 2018-08-31 | 阿速万科学有限责任公司 | 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物 |
| WO2020112937A1 (en) * | 2018-11-30 | 2020-06-04 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| US11858935B1 (en) | 2023-09-06 | 2024-01-02 | King Faisal University | Pyrrolo[2,3-c][1,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors |
| US11891394B1 (en) | 2023-09-06 | 2024-02-06 | King Faisal University | Pyrrolo[2,3-c][1,6]naphthyridine-8-carboxylic acid compounds as CK2 inhibitors |
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| US20040063744A1 (en) | 2002-05-28 | 2004-04-01 | Tao Wang | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides |
| UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
| US6900206B2 (en) | 2002-06-20 | 2005-05-31 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives |
| TW200403243A (en) | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| ATE323702T1 (de) | 2002-08-06 | 2006-05-15 | Astrazeneca Ab | Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität |
| JP2005539036A (ja) | 2002-08-21 | 2005-12-22 | グラクソ グループ リミテッド | ピリミジン化合物 |
| GB0222493D0 (en) | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
| TW200418498A (en) | 2002-09-30 | 2004-10-01 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
| FR2845388B1 (fr) | 2002-10-08 | 2004-11-12 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo[3.2.2]nonanecarboxamides, leur preparation et leur application en therapeutique |
| WO2004074286A1 (en) | 2003-02-14 | 2004-09-02 | Wyeth | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| US20040214856A1 (en) | 2003-04-23 | 2004-10-28 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| DK1753764T3 (da) | 2004-06-09 | 2009-02-16 | Glaxo Group Ltd | Pyrrolopyridin-derivater |
-
2005
- 2005-06-07 DK DK05747418T patent/DK1753764T3/da active
- 2005-06-07 BR BRPI0511874-3A patent/BRPI0511874A/pt not_active IP Right Cessation
- 2005-06-07 ES ES05747418T patent/ES2317244T3/es not_active Expired - Lifetime
- 2005-06-07 WO PCT/EP2005/006182 patent/WO2005121140A1/en not_active Ceased
- 2005-06-07 HR HR20090034T patent/HRP20090034T3/xx unknown
- 2005-06-07 DE DE602005010698T patent/DE602005010698D1/de not_active Expired - Lifetime
- 2005-06-07 AT AT05747418T patent/ATE412651T1/de not_active IP Right Cessation
- 2005-06-07 UY UY28945A patent/UY28945A1/es unknown
- 2005-06-07 PT PT05747418T patent/PT1753764E/pt unknown
- 2005-06-07 JP JP2007526300A patent/JP2008501758A/ja not_active Withdrawn
- 2005-06-07 TW TW094118669A patent/TW200611695A/zh unknown
- 2005-06-07 PL PL05747418T patent/PL1753764T3/pl unknown
- 2005-06-07 AR ARP050102327A patent/AR050158A1/es unknown
- 2005-06-07 MX MXPA06014471A patent/MXPA06014471A/es unknown
- 2005-06-07 PE PE2005000651A patent/PE20060430A1/es not_active Application Discontinuation
- 2005-06-07 AU AU2005251913A patent/AU2005251913A1/en not_active Abandoned
- 2005-06-07 EP EP05747418A patent/EP1753764B1/en not_active Expired - Lifetime
- 2005-06-07 CA CA002569887A patent/CA2569887A1/en not_active Abandoned
- 2005-06-07 KR KR1020077000449A patent/KR20070034049A/ko not_active Withdrawn
- 2005-06-07 SI SI200530497T patent/SI1753764T1/sl unknown
- 2005-06-07 RU RU2006147278/04A patent/RU2006147278A/ru not_active Application Discontinuation
- 2005-06-07 US US11/570,099 patent/US7589206B2/en not_active Expired - Fee Related
-
2006
- 2006-11-27 IL IL179603A patent/IL179603A0/en unknown
- 2006-12-28 MA MA29569A patent/MA28686B1/fr unknown
-
2007
- 2007-01-04 NO NO20070067A patent/NO20070067L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005121140A1 (en) | 2005-12-22 |
| HRP20090034T3 (en) | 2009-03-31 |
| US20070219229A1 (en) | 2007-09-20 |
| UY28945A1 (es) | 2006-01-31 |
| PT1753764E (pt) | 2009-01-28 |
| RU2006147278A (ru) | 2008-07-20 |
| SI1753764T1 (sl) | 2009-02-28 |
| AU2005251913A1 (en) | 2005-12-22 |
| IL179603A0 (en) | 2007-05-15 |
| HK1104175A1 (en) | 2008-01-04 |
| US7589206B2 (en) | 2009-09-15 |
| KR20070034049A (ko) | 2007-03-27 |
| MA28686B1 (fr) | 2007-06-01 |
| PL1753764T3 (pl) | 2009-04-30 |
| TW200611695A (en) | 2006-04-16 |
| BRPI0511874A (pt) | 2008-01-15 |
| AR050158A1 (es) | 2006-10-04 |
| EP1753764B1 (en) | 2008-10-29 |
| EP1753764A1 (en) | 2007-02-21 |
| ATE412651T1 (de) | 2008-11-15 |
| JP2008501758A (ja) | 2008-01-24 |
| DK1753764T3 (da) | 2009-02-16 |
| NO20070067L (no) | 2007-02-09 |
| ES2317244T3 (es) | 2009-04-16 |
| MXPA06014471A (es) | 2007-03-21 |
| CA2569887A1 (en) | 2005-12-22 |
| DE602005010698D1 (de) | 2008-12-11 |
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