PE20050074A1 - Nuevos compuestos de triazol como inhibidores del factor de crecimiento transformante - Google Patents

Nuevos compuestos de triazol como inhibidores del factor de crecimiento transformante

Info

Publication number
PE20050074A1
PE20050074A1 PE2003000947A PE2003000947A PE20050074A1 PE 20050074 A1 PE20050074 A1 PE 20050074A1 PE 2003000947 A PE2003000947 A PE 2003000947A PE 2003000947 A PE2003000947 A PE 2003000947A PE 20050074 A1 PE20050074 A1 PE 20050074A1
Authority
PE
Peru
Prior art keywords
growth factor
transforming growth
methylpyridin
triazol
inhibitors
Prior art date
Application number
PE2003000947A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20050074A1 publication Critical patent/PE20050074A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA Ia, Ib O Ic, A UNA SAL, TAUTOMERO HIDRATO Y SOLVATO DEL MISMO DONDE R1 ES ANILLO SATURADO, INSATURADO O AROMATICO MONO-, BI- O POLICICLICO C3-C20 CON AL MENOS UN HETEROATOMO S, O, N. O TAMBIEN R1 ES CARBONILO, HALO, OXO, ENTRE OTROS. R3 ES H, HALO, HALOALQUILO C1-C6, ENTRE OTROS; R6 ES H, ALQUILO C1-C6, HETEROCICLILO C5-C10, ENTRE OTROS; s ES 1-5. SON COMPUESTOS PREFERIDOS: 3-ISOPROPIL-6-[5-(3-METILPIRIDIN-2-IL)-2H-[1,2,3]TRIAZOL-4-IL-[1,2,4]TRIAZOLO[4,3-a]PIRIDINA; 3-METIL-6-[5-(6-METILPIRIDIN-2-IL)-2H-[1,2,3]TRIAZOL-4-IL]-[1,2,4]TRIAZOLO[4,3-a]PIRIDINA Y 6-[5-(6-METILPIRIDIN-2-IL)-2H-[1,2,3]TRIAZOL-4-IL]-QUINAZOLINA; ENTRE OTROS. TAMBIEN REFERIDA A LA PREPARACION DE DICHO COMPUESTO CUYA UTILIDAD SE HAYA EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON EL FACTOR DE CRECIMIENTO TRANSFORMANTE (TGF) COMO LAS FIBROTICAS, EL CANCER, LA ESCLERODERMIA Y LA CICATRIZACION DERMICA, ENTRE OTRAS
PE2003000947A 2002-09-18 2003-09-16 Nuevos compuestos de triazol como inhibidores del factor de crecimiento transformante PE20050074A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41207902P 2002-09-18 2002-09-18
US48453503P 2003-07-02 2003-07-02

Publications (1)

Publication Number Publication Date
PE20050074A1 true PE20050074A1 (es) 2005-03-21

Family

ID=32033582

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000947A PE20050074A1 (es) 2002-09-18 2003-09-16 Nuevos compuestos de triazol como inhibidores del factor de crecimiento transformante

Country Status (25)

Country Link
US (2) US7053095B2 (es)
EP (1) EP1542685A1 (es)
JP (1) JP2006502236A (es)
KR (1) KR20050057393A (es)
CN (1) CN1681502A (es)
AP (1) AP2005003260A0 (es)
AR (1) AR041276A1 (es)
AU (1) AU2003260810A1 (es)
BR (1) BR0314577A (es)
CA (1) CA2497971A1 (es)
CO (1) CO5540390A2 (es)
EA (1) EA200500376A1 (es)
EC (1) ECSP055681A (es)
HR (1) HRP20050251A2 (es)
IS (1) IS7713A (es)
MA (1) MA27442A1 (es)
MX (1) MXPA05002982A (es)
NO (1) NO20051010L (es)
OA (1) OA12927A (es)
PA (1) PA8583401A1 (es)
PE (1) PE20050074A1 (es)
PL (1) PL375974A1 (es)
TW (1) TW200412346A (es)
UY (1) UY27981A1 (es)
WO (1) WO2004026307A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27304A1 (es) 2001-05-24 2002-12-31 Avanir Pharmaceuticals Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación
CN1681501A (zh) * 2002-09-18 2005-10-12 辉瑞产品公司 作为转化生长因子(tgf)抑制剂的吡唑衍生物
CN1681810A (zh) 2002-09-18 2005-10-12 辉瑞产品公司 作为转化生长因子(tgf)抑制剂的新的噁唑和噻唑化合物
OA12928A (en) * 2002-09-18 2006-10-13 Pfizer Prod Inc Novel imidazole compounds as transforming growth factor (TGF) inhibitors.
PA8595001A1 (es) * 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
PT1854789E (pt) * 2005-02-23 2013-10-23 Shionogi & Co Derivado de quinazolina possuindo actividade inibidora de tirosina-cinase
CA2614919C (en) 2005-07-25 2015-06-23 Zachary Demko 1, 2, 3 -triazoles inhibitors of tubulin polymerization for the treatment of proliferative disorders
CN101330914A (zh) * 2005-12-16 2008-12-24 爱尔康公司 使用alk5调节剂控制眼内压
DE102005061840A1 (de) 2005-12-23 2007-06-28 Merck Patent Gmbh Triazolderivate
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009077A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
US8871744B2 (en) 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
WO2013078286A1 (en) 2011-11-22 2013-05-30 Cornell University Methods for stimulating hematopoietic recovery by inhibiting tgf beta signaling
EA032679B1 (ru) 2012-10-05 2019-07-31 Кадмон Корпорейшн, Ллк Человеческие анти-vegfr-2/kdr-антитела
SI2970890T1 (sl) 2013-03-14 2020-10-30 The Brigham And Women's Hospital, Inc. Sestavki in postopki za razmnoževanje in kultiviranje epitelijskih matičnih celic
CA2935392C (en) 2014-01-01 2022-07-26 Medivation Technologies, Inc. Amino pyridine derivatives for the treatment of conditions associated with excessive tgf.beta activity
EP3189134A1 (en) 2014-09-03 2017-07-12 The Brigham and Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
CN107108615B (zh) 2015-03-04 2020-11-20 吉利德科学公司 Toll样受体调节性4,6-二氨基-吡啶并[3,2-D]嘧啶化合物
US11021687B2 (en) 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
EP3507276B1 (en) 2016-09-02 2021-11-03 Gilead Sciences, Inc. Toll like receptor modulator compounds
SG10201910821XA (en) 2016-12-30 2020-01-30 Frequency Therapeutics Inc 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
EP3768267A4 (en) 2018-03-20 2022-04-20 Icahn School of Medicine at Mount Sinai KINA INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
US20210309679A1 (en) 2018-07-23 2021-10-07 Guangzhou Othrotx Co., Ltd. Bisphosphonate drug conjugates
AU2019321641A1 (en) 2018-08-17 2021-04-15 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating Jag-1
WO2020037326A1 (en) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating foxo
CA3124700A1 (en) 2018-12-31 2020-07-09 Icahn School Of Medicine At Mount Sinai Kinase inhibitor compounds and compositions and methods of use
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
CN112694477B (zh) * 2019-10-22 2024-02-06 四川科伦博泰生物医药股份有限公司 吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6058981A (ja) * 1983-09-09 1985-04-05 Takeda Chem Ind Ltd ５−ピリジル−１，３−チアゾ−ル誘導体，その製造法およびそれを含んでなる医薬組成物
JPS6025142A (ja) 1983-07-21 1985-02-07 Matsushita Electric Ind Co Ltd 表示装置の電極製造方法
DE3486009T2 (de) * 1983-09-09 1993-04-15 Takeda Chemical Industries Ltd 5-pyridyl-1,3-thiazol-derivate, ihre herstellung und anwendung.
GB9201692D0 (en) * 1992-01-27 1992-03-11 Smithkline Beecham Intercredit Compounds
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
AU7726898A (en) 1997-05-22 1998-12-11 G.D. Searle & Co. Pyrazole derivatives as p38 kinase inhibitors
JP2002502379A (ja) 1997-05-22 2002-01-22 ジー．ディー．サール アンド カンパニー ｐ３８キナーゼインヒビターとしての３（５）−ヘテロアリール置換ピラゾール
EP1027050B1 (en) * 1997-10-27 2004-01-14 Takeda Chemical Industries, Ltd. 1,3-thiazoles as adenosine a3 receptor antagonists for the treatment of allergy, asthma and diabetes
US6465493B1 (en) 1999-04-09 2002-10-15 Smithkline Beecham Corporation Triarylimidazoles
JP2000302680A (ja) * 1999-04-23 2000-10-31 Takeda Chem Ind Ltd 脳保護剤
WO2001010865A1 (fr) * 1999-08-06 2001-02-15 Takeda Chemical Industries, Ltd. INHIBITEURS DE p38MAP KINASE
AR029803A1 (es) 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
GB0007405D0 (en) 2000-03-27 2000-05-17 Smithkline Beecham Corp Compounds
PE20020506A1 (es) 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
EP1349851A4 (en) 2000-11-16 2004-09-08 Smithkline Beecham Corp COMPOUNDS
GB0027987D0 (en) 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
CA2436739A1 (en) * 2000-12-26 2002-07-04 Takeda Chemical Industries, Ltd. Combination agent
GB0100762D0 (en) 2001-01-11 2001-02-21 Smithkline Beecham Plc Novel use
GB0102665D0 (en) * 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
US20040097502A1 (en) 2001-02-02 2004-05-20 Gellibert Francoise Jeanne Pyrazoles as tgf inhibitors
GB0102672D0 (en) 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
GB0102673D0 (en) * 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
GB0102668D0 (en) * 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
WO2002066462A1 (en) 2001-02-02 2002-08-29 Glaxo Group Limited Pyrazole derivatives against tgf overexpression
JPWO2002062775A1 (ja) * 2001-02-02 2004-06-10 山之内製薬株式会社 ２−アシルアミノチアゾール誘導体又はその塩
WO2002100433A1 (en) * 2001-06-11 2002-12-19 Takeda Chemical Industries, Ltd. Medicinal compositions
AR039241A1 (es) 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
GB0217780D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Compounds
JP2005539000A (ja) 2002-07-31 2005-12-22 スミスクライン・ビーチャム・コーポレイション Ａｌｋ５阻害剤としての２−フェニルピリジン−４−イル誘導体

Also Published As

Publication number Publication date
EP1542685A1 (en) 2005-06-22
US20060128761A1 (en) 2006-06-15
HRP20050251A2 (en) 2005-10-31
PA8583401A1 (es) 2004-04-23
MXPA05002982A (es) 2005-06-22
US7053095B2 (en) 2006-05-30
AP2005003260A0 (en) 2005-03-31
CN1681502A (zh) 2005-10-12
TW200412346A (en) 2004-07-16
IS7713A (is) 2005-02-24
UY27981A1 (es) 2004-04-30
CA2497971A1 (en) 2004-04-01
KR20050057393A (ko) 2005-06-16
BR0314577A (pt) 2005-08-09
AR041276A1 (es) 2005-05-11
PL375974A1 (en) 2005-12-12
US20040110798A1 (en) 2004-06-10
OA12927A (en) 2006-10-13
MA27442A1 (fr) 2005-07-01
EA200500376A1 (ru) 2005-08-25
ECSP055681A (es) 2005-05-30
JP2006502236A (ja) 2006-01-19
NO20051010L (no) 2005-05-31
CO5540390A2 (es) 2005-07-29
AU2003260810A1 (en) 2004-04-08
WO2004026307A1 (en) 2004-04-01

Similar Documents

Publication Publication Date Title
PE20050074A1 (es) Nuevos compuestos de triazol como inhibidores del factor de crecimiento transformante
PE20050072A1 (es) Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf)
PE20050076A1 (es) Nuevos compuestos de isotiazol e isoxazol como inhibidores del factor de crecimiento transformador (tgf)
MXPA05012466A (es) Derivados de quinolina como inhibidores de fosfodiesterasa.
ATE443063T1 (de) Ä1,2,4ütriazoloä4,3-aüpyridin-derivative zur behandlung hyperproliferativer erkrankungen
DE69724811D1 (de) Pentafluorobenzensulfonamide und analoge
MA27582A1 (fr) Derives benzazepine pour le traitement de troubles neurologiques
MX2007003321A (es) Derivados heterociclicos y su uso como agentes terapeuticos.
MXPA02011426A (es) Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa.
ATE407679T1 (de) Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
HUP0004556A2 (hu) Tetrazoltartalmú repamicin analógok és ezek alkalmazása gyógyászati készítmények előállítására
PE20050306A1 (es) Compuestos imidazol condensado, 2-piridilo sustituido como inhibidores del factor de crecimiento transformante (tgf)
PL373414A1 (en) 8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands
RU2006138597A (ru) Производные тетрагидронафтиридина и способ их получения
PE20071090A1 (es) 5-pirazolpiperidinas-(sustituidas)
TR200200989T2 (tr) Farmasötik açıdan aktif bileşikler.
PE20120120A1 (es) DERIVADOS DE 2H-PIRAZOLO[3,4-d]PIRIMIDINA-4,6(5H,7H)-DIONA, COMO INHIBIDORES DE PDE1
PE20010130A1 (es) Derivados de 3(5)-amino-pirazol y procedimiento para su preparacion
SG146658A1 (en) Haloalkyl containing compounds as cysteine protease inhibitors
ATE540928T1 (de) Isochinolinverbindungen und ihre medizinische verwendung
ATE428427T1 (de) Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
MXPA05007462A (es) Derivados de pirrolopiridazina.
PE20060455A1 (es) Nucleosidos de 3-beta-d-ribofuranosiltiazolo[4,5-d]pirimidina
RU2008104510A (ru) Производные индолилмалеинимида
EA202190323A1 (ru) ИМИДАЗО[1,2-b]ПИРИДАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ Trk

Legal Events

Date Code Title Description
FC Refusal