PE20060455A1 - Nucleosidos de 3-beta-d-ribofuranosiltiazolo[4,5-d]pirimidina - Google Patents

Nucleosidos de 3-beta-d-ribofuranosiltiazolo[4,5-d]pirimidina

Info

Publication number
PE20060455A1
PE20060455A1 PE2005000655A PE2005000655A PE20060455A1 PE 20060455 A1 PE20060455 A1 PE 20060455A1 PE 2005000655 A PE2005000655 A PE 2005000655A PE 2005000655 A PE2005000655 A PE 2005000655A PE 20060455 A1 PE20060455 A1 PE 20060455A1
Authority
PE
Peru
Prior art keywords
beta
ribofuranosyltiazole
alkyl
pyrimidine
pyrimidine nucleosides
Prior art date
Application number
PE2005000655A
Other languages
English (en)
Inventor
Devron R Averett
Stephen E Webber
Erik J Rueden
Alan X Xiang
David Louis Clark
Joseph R Lennox
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34959084&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060455(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Publication of PE20060455A1 publication Critical patent/PE20060455A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE BETA-D-RIBOFURANOSILTIAZOLO[4,5-d]PIRIMIDINA DE FORMULA I, DONDE R1a, R1b Y R1c SON H, C(O)R3, ENTRE OTROS; R2 ES H, OR5; R3 ES ALQUILO C1-C18; R5 ES H, ALQUILO C1-C6, ALQUENILO C3-C7, ENTRE OTROS; CON LA CONDICION DE QUE R5 NO SEA -CH3 Y CON LA CONDICION DE QUE AL MENOS UNO DE R1a, R1b Y R1c NO SEA H CUANDO R2 ES H. SON COMPUESTOS PREFERIDOS: DICLORHIDRATO DE 5-AMINO-3-(5'-O-L-VALINIL-BETA-D-RIBOFURANOSIL)TIAZOLO[4,5-d]PIRIMIDINA-2,7-DIONA, 5-AMINO-3-BETA-D-RIBOFURANOSIL-7-METOXI-TIAZOLO[4,5-d]PIRIMIDIN-2-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES POR SU ACTIVIDAD INMUNOMODULADORA
PE2005000655A 2004-06-07 2005-06-07 Nucleosidos de 3-beta-d-ribofuranosiltiazolo[4,5-d]pirimidina PE20060455A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2004/018011 WO2005121162A1 (en) 2004-06-07 2004-06-07 3-β-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF

Publications (1)

Publication Number Publication Date
PE20060455A1 true PE20060455A1 (es) 2006-06-19

Family

ID=34959084

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000655A PE20060455A1 (es) 2004-06-07 2005-06-07 Nucleosidos de 3-beta-d-ribofuranosiltiazolo[4,5-d]pirimidina

Country Status (21)

Country Link
US (1) US20080070852A1 (es)
EP (1) EP1758916B1 (es)
JP (1) JP4856638B2 (es)
CN (1) CN1964985A (es)
AR (1) AR049203A1 (es)
AU (1) AU2004320625B2 (es)
BR (1) BRPI0418887A (es)
CA (1) CA2566541C (es)
ES (1) ES2399891T3 (es)
IL (1) IL179529A0 (es)
IS (1) IS8575A (es)
MX (1) MXPA06014182A (es)
NO (1) NO20070061L (es)
PA (1) PA8635901A1 (es)
PE (1) PE20060455A1 (es)
RU (1) RU2006146204A (es)
SV (1) SV2006002135A (es)
TN (1) TNSN06403A1 (es)
TW (1) TW200612969A (es)
UY (1) UY28943A1 (es)
WO (1) WO2005121162A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0009486D0 (en) 2000-04-17 2000-06-07 Univ Cardiff Chemical compounds
SI2561872T1 (sl) * 2004-12-17 2015-02-27 Anadys Pharmaceuticals, Inc. 3,5-disubstituirane in 3,5,7-trisubstituiran-3H-oksazolo in 3H-tiazolo(4,5-d)pirimidin-2-onske spojine in njihova predzdravila
EP2007789B1 (en) 2006-04-11 2015-05-20 Novartis AG Spirocyclic HCV/HIV inhibitors and their uses
GB0609178D0 (en) * 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
AR061024A1 (es) * 2006-05-22 2008-07-30 Novartis Ag Maleato de 5-amino-3- (2'3'-di-o-acetil-beta-d-ribofuranosil)-3h-tiazolo[4,5-d] pirimidin-2-ona.
BRPI0717741A2 (pt) * 2006-10-17 2014-04-08 Anadys Pharmaceuticals Inc Compostos e respectivos método de preparação, método de redução de composto de sulfonil substituído, composição farmacêutica método de tratamento ou prevenção de doença
PL2014771T3 (pl) * 2007-06-25 2015-05-29 Anadys Pharmaceuticals Inc Ciągły proces hydrolizy enzymatycznej
EP2019113A1 (en) * 2007-07-26 2009-01-28 Anadys Pharmaceuticals, Inc. New Crystalline Salts of 5-Amino-3-(2',3'-di-O-acetyl-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
KR101848099B1 (ko) * 2009-09-21 2018-04-11 길리애드 사이언시즈, 인코포레이티드 1'-치환된 카바-뉴클레오사이드 유사체의 제조를 위한 방법 및 중간체
US9011833B2 (en) 2010-10-08 2015-04-21 Novartis Ag Vitamin E formulations of sulfamide NS3 inhibitors
CN102153548B (zh) * 2011-02-24 2012-11-28 河北大学 一种含有噻唑（嗪）烷酮环的类核苷衍生物及其制备方法和其在药物制剂中的应用
WO2023196458A1 (en) * 2022-04-06 2023-10-12 VenatoRx Pharmaceuticals, Inc. Orally-bioavailable nucleoside analogs
CN116589606B (zh) * 2022-12-01 2024-05-28 中国药科大学 一种丁酰化酵母葡聚糖及其制备方法、应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880784A (en) * 1987-12-21 1989-11-14 Brigham Young University Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US5041426A (en) * 1987-12-21 1991-08-20 Brigham Young University Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides
UA79764C2 (en) 2001-11-27 2007-07-25 Anadys Pharmaceuticals Inc 3-?-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF

Also Published As

Publication number Publication date
JP2008501792A (ja) 2008-01-24
AU2004320625B2 (en) 2009-08-27
AR049203A1 (es) 2006-07-05
EP1758916B1 (en) 2012-11-21
WO2005121162A1 (en) 2005-12-22
AU2004320625A1 (en) 2005-12-22
EP1758916A1 (en) 2007-03-07
RU2006146204A (ru) 2008-07-20
CA2566541A1 (en) 2005-12-22
IS8575A (is) 2006-12-05
SV2006002135A (es) 2006-05-08
MXPA06014182A (es) 2007-06-25
US20080070852A1 (en) 2008-03-20
UY28943A1 (es) 2006-01-31
NO20070061L (no) 2007-03-05
CA2566541C (en) 2012-10-09
TW200612969A (en) 2006-05-01
PA8635901A1 (es) 2006-07-03
CN1964985A (zh) 2007-05-16
IL179529A0 (en) 2007-05-15
TNSN06403A1 (en) 2008-02-22
ES2399891T3 (es) 2013-04-04
BRPI0418887A (pt) 2007-10-30
JP4856638B2 (ja) 2012-01-18

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