PE20040927A1 - Derivados de 1-propanolol y 1-propilamina, como ligandos de receptores de glucocorticoides - Google Patents
Derivados de 1-propanolol y 1-propilamina, como ligandos de receptores de glucocorticoidesInfo
- Publication number
- PE20040927A1 PE20040927A1 PE2004000019A PE2004000019A PE20040927A1 PE 20040927 A1 PE20040927 A1 PE 20040927A1 PE 2004000019 A PE2004000019 A PE 2004000019A PE 2004000019 A PE2004000019 A PE 2004000019A PE 20040927 A1 PE20040927 A1 PE 20040927A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- hydroxy
- alkenyl
- optionally substituted
- Prior art date
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
SE REFIERE A COMPUESTOS DE FORMULA IA Y IB, EN DONDE R1 ES ARILO, HETEROARILO O CICLOALQUILO(C5-C15) OPCIONALMENTE MONO A TRI-SUSTITUIDO POR ALQUILO (C1-C5), ALQUENILO(C2-C5), ALQUINILO(C2-C5), CICLOALQUILO(C3-C8), ENTRE OTROS; R2 Y R3 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C5) O ARILALQUILO(C1-C5), O JUNTOS CON EL C AL QUE ESTAN UNIDOS, FORMAN UN ANILLO ESPIRO DE CICLOALQUILO(C3-C8); O R1 Y R2 EN CONJUNTO FORMAN UN CROMANILO O DIHIDROBENZOFURANILO OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C5), ALQUENILO(C2-C5), ALQUINILO(C2-C5), CICLOALQUILO(C3-C8), ENTRE OTROS; R4 ES CARBONILO O METILENO OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C3), HIDROXI Y HALOGENO; R5 ES PIRROLIDINA, MORFOLINA, TIOMORFOLINA, PIPERAZINA, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS POR ALQUILO(C1-C5), ALQUENILO(C2-C5), ALQUINILO(C2-C5), ENTRE OTROS; X ES HIDROXI O AMINO, EN DONDE EL N ESTA OPCIONALMENTE MONO O DISUSTITUIDO POR ALQUILO(C1-C5). SON COMPUESTOS PREFERIDOS: 1-{4-[4-(5-FLUOR-2-METOXIFENIL)-2-HIDROXI-4-METIL-2-TRIFLUOROMETILPENTIL]-2,6-DIMETILPIPERAZIN-1-IL}ETANONA, 4-[4-(5-FLUOR-2-METOXIFENIL)-2-HIDROXI-4-METIL-2-TRIFLUOROMETILPENTIL]-2,6-DIMETILPIPERAZIN-1-CARBALDEHIDO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS MODULAN LA FUNCION DEL RECEPTOR DE GLUCOCORTICOIDES Y SON UTILES PARA TRATAR ESTADOS PATOLOGICOS O TRASTORNOS MEDIADOS POR ESTE RECEPTOR, COMO PROCESOS INFLAMATORIOS, ALERGICOS O PROLIFERATIVOS Y TAMBIEN EN EL TRATAMIENTO DE DIABETES
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DE19856475A1 (de) * | 1998-11-27 | 2000-05-31 | Schering Ag | Nichtsteroidale Entzündungshemmer |
CN100400487C (zh) * | 1999-04-30 | 2008-07-09 | 辉瑞产品公司 | 糖皮质激素受体调制剂 |
US6329534B1 (en) * | 1999-09-01 | 2001-12-11 | Abbott Laboratories | Glucocorticoid receptor antagonists for treatment of diabetes |
US6436986B1 (en) * | 1999-09-01 | 2002-08-20 | Abbott Laboratories | Glucocorticoid receptor antagonists for treatment of diabetes |
DE10038639A1 (de) | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
US6583180B2 (en) * | 2001-02-14 | 2003-06-24 | Abbott Laboratories | Glucocorticoid receptor modulators |
ATE437853T1 (de) | 2001-02-14 | 2009-08-15 | Karobio Ab | Glucocorticoid-rezeptoren-modulatoren |
ES2276038T3 (es) * | 2002-01-14 | 2007-06-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para su obtencion, formulaciones farmaceuticas que los contienen y usos de los mismos. |
EP1490317A1 (en) * | 2002-03-26 | 2004-12-29 | Boehringer Ingelheim Pharmaceuticals Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
EA008830B1 (ru) * | 2002-03-26 | 2007-08-31 | Бёрингер Ингельхайм Фармасьютиклз, Инк. | Миметики глюкокортикоидов, способы их получения, фармацевтические композиции и их применение |
US7186864B2 (en) * | 2002-05-29 | 2007-03-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
US7074806B2 (en) * | 2002-06-06 | 2006-07-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
BR0313923A (pt) * | 2002-08-29 | 2005-07-12 | Boehringer Ingelheim Pharma | Derivados de 3-(sulfonamidoetil)-indol para uso como miméticos de glicocorticóide no tratamento de doenças inflamatórias, alérgicas e proliferativas |
-
2003
- 2003-12-18 RU RU2005124558/04A patent/RU2005124558A/ru not_active Application Discontinuation
- 2003-12-18 CA CA002512257A patent/CA2512257A1/en not_active Abandoned
- 2003-12-18 WO PCT/US2003/040942 patent/WO2004063163A1/en active Application Filing
- 2003-12-18 KR KR1020057012524A patent/KR20050109922A/ko not_active Application Discontinuation
- 2003-12-18 US US10/739,208 patent/US7579469B2/en active Active
- 2003-12-18 AU AU2003297471A patent/AU2003297471A1/en not_active Abandoned
- 2003-12-18 EP EP03815237A patent/EP1583745A1/en not_active Withdrawn
- 2003-12-18 JP JP2004566584A patent/JP4373926B2/ja not_active Expired - Fee Related
- 2003-12-18 BR BR0317928-1A patent/BR0317928A/pt not_active IP Right Cessation
- 2003-12-18 MX MXPA05006872A patent/MXPA05006872A/es unknown
- 2003-12-30 AR ARP030104868A patent/AR042875A1/es not_active Suspension/Interruption
-
2004
- 2004-01-02 UY UY28157A patent/UY28157A1/es not_active Application Discontinuation
- 2004-01-02 MY MYPI20040009A patent/MY135423A/en unknown
- 2004-01-02 TW TW093100060A patent/TW200418815A/zh unknown
- 2004-01-05 PE PE2004000019A patent/PE20040927A1/es not_active Application Discontinuation
-
2005
- 2005-06-30 IL IL169477A patent/IL169477A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2512257A1 (en) | 2004-07-29 |
RU2005124558A (ru) | 2006-04-10 |
JP2006516256A (ja) | 2006-06-29 |
US7579469B2 (en) | 2009-08-25 |
JP4373926B2 (ja) | 2009-11-25 |
IL169477A0 (en) | 2007-07-04 |
TW200418815A (en) | 2004-10-01 |
BR0317928A (pt) | 2005-11-29 |
MXPA05006872A (es) | 2005-08-16 |
EP1583745A1 (en) | 2005-10-12 |
MY135423A (en) | 2008-04-30 |
KR20050109922A (ko) | 2005-11-22 |
WO2004063163A1 (en) | 2004-07-29 |
UY28157A1 (es) | 2004-07-30 |
AU2003297471A1 (en) | 2004-08-10 |
US20040162321A1 (en) | 2004-08-19 |
AR042875A1 (es) | 2005-07-06 |
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