AR062630A1 - Derivados de bipiridina sustituidos y su uso - Google Patents

Derivados de bipiridina sustituidos y su uso

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Publication number
AR062630A1
AR062630A1 ARP070103888A ARP070103888A AR062630A1 AR 062630 A1 AR062630 A1 AR 062630A1 AR P070103888 A ARP070103888 A AR P070103888A AR P070103888 A ARP070103888 A AR P070103888A AR 062630 A1 AR062630 A1 AR 062630A1
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AR
Argentina
Prior art keywords
alkyl
amino
alkoxy
substituted
hydroxy
Prior art date
Application number
ARP070103888A
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English (en)
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Bayer Healthcare Ag
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Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of AR062630A1 publication Critical patent/AR062630A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invencion se refiere a derivados de 2,4'- y 3,4'-bipiridina sustituidos, procedimientos para su preparacion, su uso para el tratamiento y/o la profilaxis de enfermedades así como su uso para la preparacion de medicamentos para el tratamiento y/o profilaxis de enfermedades, preferiblemente para el tratamiento y/o la prevencion de hipertonía y otras enfermedades cardiovasculares. Reivindicacion 1: Compuestos de formula (1), en la que uno de los dos miembros de anillo X e Y representan N y otro representa C- R6, en la que R6 significa hidrogeno o alquilo (C1-4), Z representa N-R7 u O, en la que R7 significa hidrogeno o alquilo (C1-4), que puede estar sustituido con hidroxi o alcoxi (C1-4), R1 y R2 son iguales o distintos y representan independientemente uno de otro hidrogeno o alquilo (C1-6), que puede estar sustituido una o dos veces, iguales o distintas, con hidroxi, alcoxi (C1-4), amino, mono-alquil (C1-4)-amino, di-alquil (C1-4)-amino, carboxilo, alcoxi (C1-4)-carbonilo y/o un heterociclo de 4 a 7 miembros, en donde el heterociclo citado contiene uno o dos heteroátomos de anillo de grupo de N, O y/o S y por su parte puede estar sustituido una o dos veces, iguales o distintas, con alquilo (C1- 4), hidroxi, oxo y/o alcoxi (C1-4), o R1 y R2 junto con el átomo de nitrogeno al que están unidos forman un heterociclo de 4 a 7 miembros, que contiene un heteroátomo de anillo adicional del grupo de N, O o S y puede estar sustituido una o dos veces, iguales o distintas, con alquilo (C1-4), hidroxi, oxo y/o alcoxi (C1-4), R3 representa hidrogeno o alquilo (C1-6), que pueden estar sustituido una o dosn veces, iguales o distintas, con cicloalquilo (C3-6), oxo, hidroxi, alcoxi (C1-4), carboxilo, amino, mono-alquil (C1-4), -amino y/o di-alquil (C1-4)-amino, o representa cicloalquilo (C4-6), en donde los restos cicloalquilo citados por su parte pueden estar sustituidos hasta dos veces, iguales o distintas, con alquilo (C1-4), hidroxi, oxo y/o alcoxi (C1-4) y en estos restos cicloalquilo puede estar reemplazado un grupo CH2 del anillo por un átomo de O, R4 representa hidrogeno, halogeno, alquilo (C1-4) o alcoxi (C1-4), en los que alquilo y alcoxi pueden estar sustituidos hasta tres veces con fluor, y R5 representa arilo (C6-10) o heteroarilo de 5 a 10 miembros con hasta tres heteroátomos de aniollo del grupo de N, O y/o S, que respectivamente (i) pueden estar sustituidos una o dos veces, iguales o distintas, con halogeno, nitro, ciano, alquilo (C1-6), fenilo, hidroxi, alcoxi (C1-6), amino, mono-alquil (C1-6)-amino, mono-alquenil (C2-6)- amino y/o di-alquil (C1-6)-amino y/o (ii) pueden estar sustituidos con pirrolidino, piperidino, morfolino, piperazino, N'- alquil (C1-4)-piperazino o un grupo de formula -L-R8, en el que L significa un enlace, NH u O, y R8 significa fenilo o heteroarilo de 5 o 6 miembros con hasta tres heteroátomos de anillo del grupo de N, O y/o S, que estar sustituido respectivamente una a tres veces, iguales o distintas, con halogeno, nitro, ciano, alquilo C1-6), trifluorometilo, hidroxi, alcoxi (C1-4), difluorometoxi, trifluorometoxi, amino, mono-alquil (C1-6)-amino, di-alquil (C1-6)-amino, alcoxi (C1-6)-carbonilo y/o carboxilo, así como sus sales, solvatos y solvatos de las sales.
ARP070103888A 2006-09-08 2007-09-03 Derivados de bipiridina sustituidos y su uso AR062630A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006042143A DE102006042143A1 (de) 2006-09-08 2006-09-08 Neue substituierte Bipyridin-Derivate und ihre Verwendung

Publications (1)

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AR062630A1 true AR062630A1 (es) 2008-11-19

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Country Status (11)

Country Link
US (2) US8653109B2 (es)
EP (1) EP2066637A1 (es)
JP (1) JP5331693B2 (es)
AR (1) AR062630A1 (es)
CA (1) CA2662728C (es)
CL (1) CL2007002610A1 (es)
DE (1) DE102006042143A1 (es)
PE (1) PE20080772A1 (es)
TW (1) TW200823209A (es)
UY (1) UY30578A1 (es)
WO (1) WO2008028590A1 (es)

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US8653109B2 (en) 2014-02-18
DE102006042143A1 (de) 2008-03-27
UY30578A1 (es) 2008-05-02
US20100093728A1 (en) 2010-04-15
CA2662728C (en) 2015-03-31
JP5331693B2 (ja) 2013-10-30
CA2662728A1 (en) 2008-03-13
US20140155401A1 (en) 2014-06-05
EP2066637A1 (de) 2009-06-10
JP2010502659A (ja) 2010-01-28

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