AR069595A1 - Compuestos amida como refuerzos de antivirales - Google Patents
Compuestos amida como refuerzos de antiviralesInfo
- Publication number
- AR069595A1 AR069595A1 ARP080105313A ARP080105313A AR069595A1 AR 069595 A1 AR069595 A1 AR 069595A1 AR P080105313 A ARP080105313 A AR P080105313A AR P080105313 A ARP080105313 A AR P080105313A AR 069595 A1 AR069595 A1 AR 069595A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- compounds
- nitrogen
- certain drugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a compuestos que tienen propiedades inhibidoras de CYP450 y por lo tanto son utiles como refuerzos de determinadas drogas, es decir, son capaces de aumentar por lo menos una de las variables farmacocinéticas de determinadas drogas cuando se co-administran. Proporciona además el uso de dichos compuestos como mejoradores de la biodisponibilidad de determinadas drogas. Además se proporcionan métodos para la preparacion de los compuestos de la invencion y composiciones farmaceuticas para el tratamiento del HIV. Reivindicacion 1: Un compuesto de la formula (1) las sales y formas estereoisoméricas del mismo, en el cual R es H, fenilo, piridilo, alquilo C1-6 o la formula (2) en el cual A y B son en forma independiente entre sí H alquilo C1-6 sustituido en forma opcional con alquinilo, heteroarilo o un heteroátomo seleccionado entre nitrogeno, oxígeno o azufre que está sustituido en forma opcional con alquilo C1-6; o en el cual A y B junto con el nitrogeno al cual están unidos forman un anillo heterocíclico de 5 o 6 miembros, saturado, parcialmente o totalmente insaturado, que contiene desde 1 hasta 4 heteroátomos cada uno seleccionado en forma independiente entre nitrogeno, oxígeno o azufre, donde dichos heteroátomos están sustituidos en forma opcional con alquilo C1-6; R1 está seleccionado entre el grupo que comprende el grupo de formulas (3) R2 es alquilo C1-6 sustituido en forma opcional con OH, aminoalquilo, pirrolidinilo, morfolinilo, alquinilo o cicloalquilo C3-7 sustituido en forma opcional con halogeno; R3 es OH; R4 es H o alquilo; R5 es piridilo o fenilo sustituido en forma opcional con halogeno; X es O, S o N sustituido en forma opcional con alquilo C1-6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07122468 | 2007-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069595A1 true AR069595A1 (es) | 2010-02-03 |
Family
ID=39386111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105313A AR069595A1 (es) | 2007-12-06 | 2008-12-05 | Compuestos amida como refuerzos de antivirales |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8350048B2 (es) |
| EP (1) | EP2235008B1 (es) |
| JP (1) | JP5509092B2 (es) |
| KR (1) | KR101624675B1 (es) |
| CN (1) | CN101878210B (es) |
| AP (1) | AP2804A (es) |
| AR (1) | AR069595A1 (es) |
| AU (1) | AU2008333165B2 (es) |
| BR (1) | BRPI0821021A2 (es) |
| CA (1) | CA2706155C (es) |
| CL (1) | CL2008003639A1 (es) |
| EA (1) | EA019616B1 (es) |
| HK (1) | HK1149553A1 (es) |
| IL (1) | IL205489A (es) |
| MX (1) | MX2010006166A (es) |
| MY (1) | MY151005A (es) |
| NZ (1) | NZ585652A (es) |
| PA (1) | PA8806801A1 (es) |
| PE (1) | PE20091263A1 (es) |
| TW (1) | TWI438202B (es) |
| UA (1) | UA103013C2 (es) |
| UY (1) | UY31513A1 (es) |
| WO (1) | WO2009071650A2 (es) |
| ZA (1) | ZA201004025B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA026673B1 (ru) * | 2008-10-07 | 2017-05-31 | Янссен Сайенсиз Айрлэнд Юси | Амидные соединения в качестве усилителей противовирусных препаратов |
| US20120172368A1 (en) * | 2009-09-03 | 2012-07-05 | Koen Vandyck | Bis-Benzimidazole Derivatives |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| CA2833006A1 (en) * | 2011-04-22 | 2012-10-26 | Merck Sharp & Dohme Corp. | Taste-masked formulations of raltegravir |
| WO2014194519A1 (en) | 2013-06-07 | 2014-12-11 | Merck Sharp & Dohme Corp. | Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug |
| CN104000824B (zh) * | 2014-05-28 | 2016-07-06 | 中山大学 | 苯并五元杂环类化合物在制备抗hiv-1病毒药物中的应用 |
| WO2016089648A1 (en) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof |
| CN105985356B (zh) * | 2015-02-05 | 2018-06-22 | 四川大学 | 咪唑[2,1-b]噻唑衍生物及其制备方法和用途 |
| CA3007025A1 (en) | 2015-12-22 | 2017-06-29 | Kancera Ab | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity |
| AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| TWI286476B (en) | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
| MY142238A (en) * | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
| KR101327772B1 (ko) * | 2002-08-02 | 2013-11-11 | 얀센 알 앤드 디 아일랜드 | 광범위 2-아미노-벤조티아졸 설폰아미드 ｈｉｖ 프로테아제 저해제 |
| AR053845A1 (es) * | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450 |
| US8048871B2 (en) | 2006-08-18 | 2011-11-01 | Sequoia Pharmaceuticals, Inc. | Compositions and methods for inhibiting cytochrome P450 |
-
2008
- 2008-05-12 UA UAA201006463A patent/UA103013C2/uk unknown
- 2008-12-05 US US12/745,334 patent/US8350048B2/en active Active
- 2008-12-05 EP EP08855867.1A patent/EP2235008B1/en active Active
- 2008-12-05 WO PCT/EP2008/066847 patent/WO2009071650A2/en active Application Filing
- 2008-12-05 AP AP2010005285A patent/AP2804A/xx active
- 2008-12-05 PE PE2008002023A patent/PE20091263A1/es not_active Application Discontinuation
- 2008-12-05 AU AU2008333165A patent/AU2008333165B2/en not_active Ceased
- 2008-12-05 MX MX2010006166A patent/MX2010006166A/es active IP Right Grant
- 2008-12-05 KR KR1020107013595A patent/KR101624675B1/ko not_active IP Right Cessation
- 2008-12-05 MY MYPI20102496 patent/MY151005A/en unknown
- 2008-12-05 NZ NZ585652A patent/NZ585652A/en not_active IP Right Cessation
- 2008-12-05 UY UY31513A patent/UY31513A1/es unknown
- 2008-12-05 AR ARP080105313A patent/AR069595A1/es unknown
- 2008-12-05 CL CL2008003639A patent/CL2008003639A1/es unknown
- 2008-12-05 BR BRPI0821021-7A patent/BRPI0821021A2/pt not_active IP Right Cessation
- 2008-12-05 TW TW097147227A patent/TWI438202B/zh not_active IP Right Cessation
- 2008-12-05 CN CN2008801182809A patent/CN101878210B/zh not_active Expired - Fee Related
- 2008-12-05 EA EA201070691A patent/EA019616B1/ru not_active IP Right Cessation
- 2008-12-05 CA CA2706155A patent/CA2706155C/en active Active
- 2008-12-05 PA PA20088806801A patent/PA8806801A1/es unknown
- 2008-12-05 JP JP2010536465A patent/JP5509092B2/ja not_active Expired - Fee Related
-
2010
- 2010-05-02 IL IL205489A patent/IL205489A/en not_active IP Right Cessation
- 2010-06-04 ZA ZA2010/04025A patent/ZA201004025B/en unknown
-
2011
- 2011-04-13 HK HK11103719.1A patent/HK1149553A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |