PE20030977A1 - Derivados de sulfonil-piperidin como inhibidores de la gamma secretasa - Google Patents
Derivados de sulfonil-piperidin como inhibidores de la gamma secretasaInfo
- Publication number
- PE20030977A1 PE20030977A1 PE2003000130A PE2003000130A PE20030977A1 PE 20030977 A1 PE20030977 A1 PE 20030977A1 PE 2003000130 A PE2003000130 A PE 2003000130A PE 2003000130 A PE2003000130 A PE 2003000130A PE 20030977 A1 PE20030977 A1 PE 20030977A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- sulfonil
- gamma secretase
- cycloalkyl
- Prior art date
Links
- 239000003540 gamma secretase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35561802P | 2002-02-06 | 2002-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030977A1 true PE20030977A1 (es) | 2003-12-04 |
Family
ID=27734543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000130A PE20030977A1 (es) | 2002-02-06 | 2003-02-04 | Derivados de sulfonil-piperidin como inhibidores de la gamma secretasa |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7208602B2 (https=) |
| EP (1) | EP1472223A1 (https=) |
| JP (1) | JP4758609B2 (https=) |
| KR (1) | KR20040081489A (https=) |
| CN (1) | CN1628100A (https=) |
| AR (1) | AR038482A1 (https=) |
| AU (1) | AU2003210865B2 (https=) |
| BR (1) | BR0307492A (https=) |
| CA (1) | CA2478423A1 (https=) |
| CO (1) | CO5611195A2 (https=) |
| EC (1) | ECSP045218A (https=) |
| MX (1) | MXPA04007659A (https=) |
| MY (1) | MY141504A (https=) |
| NO (1) | NO329067B1 (https=) |
| NZ (1) | NZ534223A (https=) |
| PE (1) | PE20030977A1 (https=) |
| PL (1) | PL371735A1 (https=) |
| RU (1) | RU2004126864A (https=) |
| TW (1) | TW200302717A (https=) |
| WO (1) | WO2003066592A1 (https=) |
| ZA (1) | ZA200406237B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100562516C (zh) | 2001-12-27 | 2009-11-25 | 第一制药株式会社 | β-淀粉样蛋白产生和分泌的抑制剂 |
| US20040171614A1 (en) * | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
| US7256186B2 (en) | 2002-02-06 | 2007-08-14 | Schering Corporation | Gamma secretase inhibitors |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| WO2004080966A1 (ja) | 2003-03-14 | 2004-09-23 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| CA2526487A1 (en) | 2003-06-30 | 2005-01-06 | Daiichi Pharmaceutical Co., Ltd. | Heterocyclic methyl sulfone derivative |
| MXPA06001558A (es) | 2003-08-08 | 2006-05-15 | Schering Corp | Inhibidores de amina ciclica bace-1 que poseen un sustituyente heterociclico. |
| ES2323068T3 (es) | 2003-08-08 | 2009-07-06 | Schering Corporation | Inhibidores de bace-1 de aminas ciclicas con un sustituyente de benzamida. |
| RU2364587C2 (ru) * | 2003-10-29 | 2009-08-20 | Элан Фармасьютикалз, Инк. | N-замещенные бензолсульфонамиды |
| TWI300410B (en) * | 2004-04-05 | 2008-09-01 | Schering Corp | Novel gamma secretase inhibitors |
| CA2567343A1 (en) * | 2004-05-20 | 2005-12-01 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| PE20060481A1 (es) * | 2004-06-30 | 2006-06-19 | Schering Corp | N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas |
| KR100880972B1 (ko) * | 2004-07-13 | 2009-02-03 | 에프. 호프만-라 로슈 아게 | 설폰아마이드 유도체 |
| EP1781625B1 (en) | 2004-07-22 | 2010-12-15 | Schering Corporation | Substituted amide beta secretase inhibitors |
| EP1790637B1 (en) | 2004-09-13 | 2014-01-29 | Ono Pharmaceutical Co., Ltd. | Derivatives of N-4-piperidyl urea and medicaments containing them as active ingredient |
| GB0423356D0 (en) * | 2004-10-21 | 2004-11-24 | Merck Sharp & Dohme | Therapeutic agents |
| BRPI0614944A2 (pt) * | 2005-08-19 | 2011-04-26 | Elan Pharm Inc | inibidores sulfonamido n-bicìclicos ponte de gama-secretase |
| KR20090008217A (ko) | 2006-03-10 | 2009-01-21 | 오노 야꾸힝 고교 가부시키가이샤 | 질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는 약제 |
| ATE509956T1 (de) * | 2006-06-08 | 2011-06-15 | Helmholtz Zentrum Muenchen | Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie |
| EP2383267A1 (de) * | 2006-09-29 | 2011-11-02 | Grünenthal GmbH | Substituierte Sulfonamid-Derivate |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| CA2669917A1 (en) * | 2006-11-17 | 2008-05-22 | Dawn M. George | Aminopyrrolidines as chemokine receptor antagonists |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| US8080549B2 (en) * | 2007-01-12 | 2011-12-20 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| JP2010528036A (ja) * | 2007-05-25 | 2010-08-19 | エラン ファーマシューティカルズ，インコーポレイテッド | γセクレターゼの阻害剤としてのピラゾロピロリジン |
| JP2011523655A (ja) * | 2008-06-03 | 2011-08-18 | フレセニウス メディカル ケア ドイッチュランド ゲーエムベーハー | ガンマセクレターゼモジュレータを含む医薬組成物 |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| JP5688745B2 (ja) | 2010-03-10 | 2015-03-25 | プロビオドルグ エージー | グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤 |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| WO2014122474A1 (en) | 2013-02-07 | 2014-08-14 | Takeda Pharmaceutical Company Limited | Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2687146B1 (fr) * | 1992-02-12 | 1994-04-01 | Adir Cie | Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US6166037A (en) * | 1997-08-28 | 2000-12-26 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
| GB9800750D0 (en) * | 1998-01-14 | 1998-03-11 | Lilly Co Eli | Pharmaceutical compound |
| GB9804426D0 (en) * | 1998-03-02 | 1998-04-29 | Pfizer Ltd | Heterocycles |
| TW575561B (en) * | 1999-03-25 | 2004-02-11 | Hoffmann La Roche | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives |
| US6589978B2 (en) * | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
-
2003
- 2003-01-30 TW TW092102236A patent/TW200302717A/zh unknown
- 2003-02-04 PE PE2003000130A patent/PE20030977A1/es not_active Application Discontinuation
- 2003-02-04 AR ARP030100346A patent/AR038482A1/es unknown
- 2003-02-05 EP EP03737650A patent/EP1472223A1/en not_active Withdrawn
- 2003-02-05 CN CNA038032686A patent/CN1628100A/zh active Pending
- 2003-02-05 JP JP2003565966A patent/JP4758609B2/ja not_active Expired - Fee Related
- 2003-02-05 PL PL03371735A patent/PL371735A1/xx not_active Application Discontinuation
- 2003-02-05 WO PCT/US2003/003471 patent/WO2003066592A1/en not_active Ceased
- 2003-02-05 AU AU2003210865A patent/AU2003210865B2/en not_active Ceased
- 2003-02-05 BR BR0307492-7A patent/BR0307492A/pt not_active IP Right Cessation
- 2003-02-05 RU RU2004126864/04A patent/RU2004126864A/ru not_active Application Discontinuation
- 2003-02-05 NZ NZ534223A patent/NZ534223A/en unknown
- 2003-02-05 US US10/358,898 patent/US7208602B2/en not_active Expired - Fee Related
- 2003-02-05 KR KR10-2004-7012102A patent/KR20040081489A/ko not_active Ceased
- 2003-02-05 MY MYPI20030381A patent/MY141504A/en unknown
- 2003-02-05 CA CA002478423A patent/CA2478423A1/en not_active Abandoned
- 2003-02-05 MX MXPA04007659A patent/MXPA04007659A/es active IP Right Grant
-
2004
- 2004-08-03 EC EC2004005218A patent/ECSP045218A/es unknown
- 2004-08-04 ZA ZA200406237A patent/ZA200406237B/en unknown
- 2004-08-06 CO CO04076759A patent/CO5611195A2/es not_active Application Discontinuation
- 2004-09-03 NO NO20043696A patent/NO329067B1/no not_active IP Right Cessation
-
2005
- 2005-10-03 US US11/242,337 patent/US20060100427A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MY141504A (en) | 2010-05-14 |
| AR038482A1 (es) | 2005-01-19 |
| RU2004126864A (ru) | 2005-07-10 |
| KR20040081489A (ko) | 2004-09-21 |
| BR0307492A (pt) | 2004-11-23 |
| ZA200406237B (en) | 2005-09-22 |
| AU2003210865B2 (en) | 2008-01-31 |
| TW200302717A (en) | 2003-08-16 |
| US20040048848A1 (en) | 2004-03-11 |
| MXPA04007659A (es) | 2005-06-08 |
| CO5611195A2 (es) | 2006-02-28 |
| PL371735A1 (en) | 2005-06-27 |
| WO2003066592A1 (en) | 2003-08-14 |
| CN1628100A (zh) | 2005-06-15 |
| JP4758609B2 (ja) | 2011-08-31 |
| NZ534223A (en) | 2007-05-31 |
| EP1472223A1 (en) | 2004-11-03 |
| US20060100427A1 (en) | 2006-05-11 |
| JP2005522437A (ja) | 2005-07-28 |
| ECSP045218A (es) | 2004-09-28 |
| US7208602B2 (en) | 2007-04-24 |
| NO20043696L (no) | 2004-11-05 |
| CA2478423A1 (en) | 2003-08-14 |
| AU2003210865A1 (en) | 2003-09-02 |
| NO329067B1 (no) | 2010-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |