AU2003210865B2 - Gamma secretase inhibitors - Google Patents

Gamma secretase inhibitors Download PDF

Info

Publication number
AU2003210865B2
AU2003210865B2 AU2003210865A AU2003210865A AU2003210865B2 AU 2003210865 B2 AU2003210865 B2 AU 2003210865B2 AU 2003210865 A AU2003210865 A AU 2003210865A AU 2003210865 A AU2003210865 A AU 2003210865A AU 2003210865 B2 AU2003210865 B2 AU 2003210865B2
Authority
AU
Australia
Prior art keywords
australia
coms
arcs
date
received
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003210865A
Other languages
English (en)
Other versions
AU2003210865A1 (en
Inventor
Theodros Asberom
John W. Clader
Tao Guo
Douglas W. Hobbs
Hubert B. Josien
Dmitri A. Pissarnitski
Elizabeth M. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Pharmacopeia LLC
Original Assignee
Pharmacopeia Inc
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacopeia Inc, Schering Corp filed Critical Pharmacopeia Inc
Publication of AU2003210865A1 publication Critical patent/AU2003210865A1/en
Assigned to SCHERING CORPORATION, PHARMACOPEIA DRUG DISCOVERY, INC. reassignment SCHERING CORPORATION Request for Assignment Assignors: PHARMACOPEIA, INC., SCHERING CORPORATION
Assigned to PHARMACOPEIA, INC., SCHERING CORPORATION reassignment PHARMACOPEIA, INC. Request for Assignment Assignors: PHARMACOPEIA DRUG DISCOVERY, INC., SCHERING CORPORATION
Application granted granted Critical
Publication of AU2003210865B2 publication Critical patent/AU2003210865B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
AU2003210865A 2002-02-06 2003-02-05 Gamma secretase inhibitors Ceased AU2003210865B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35561802P 2002-02-06 2002-02-06
US60/355,618 2002-02-06
PCT/US2003/003471 WO2003066592A1 (en) 2002-02-06 2003-02-05 Gamma secretase inhibitors

Publications (2)

Publication Number Publication Date
AU2003210865A1 AU2003210865A1 (en) 2003-09-02
AU2003210865B2 true AU2003210865B2 (en) 2008-01-31

Family

ID=27734543

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003210865A Ceased AU2003210865B2 (en) 2002-02-06 2003-02-05 Gamma secretase inhibitors

Country Status (21)

Country Link
US (2) US7208602B2 (https=)
EP (1) EP1472223A1 (https=)
JP (1) JP4758609B2 (https=)
KR (1) KR20040081489A (https=)
CN (1) CN1628100A (https=)
AR (1) AR038482A1 (https=)
AU (1) AU2003210865B2 (https=)
BR (1) BR0307492A (https=)
CA (1) CA2478423A1 (https=)
CO (1) CO5611195A2 (https=)
EC (1) ECSP045218A (https=)
MX (1) MXPA04007659A (https=)
MY (1) MY141504A (https=)
NO (1) NO329067B1 (https=)
NZ (1) NZ534223A (https=)
PE (1) PE20030977A1 (https=)
PL (1) PL371735A1 (https=)
RU (1) RU2004126864A (https=)
TW (1) TW200302717A (https=)
WO (1) WO2003066592A1 (https=)
ZA (1) ZA200406237B (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100927304B1 (ko) 2001-12-27 2009-11-18 다이이찌 세이야꾸 가부시기가이샤 β-아밀로이드 단백 생산·분비 저해제
US20040171614A1 (en) * 2002-02-06 2004-09-02 Schering-Plough Corporation Novel gamma secretase inhibitors
US7256186B2 (en) 2002-02-06 2007-08-14 Schering Corporation Gamma secretase inhibitors
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
RU2366655C2 (ru) 2003-03-14 2009-09-10 Оно Фармасьютикал Ко., Лтд. Азотсодержащие гетероциклические производные и лекарственные средства, содержащие их в качестве активного ингредиента
PL379466A1 (pl) 2003-06-30 2006-09-18 Daiichi Sankyo Company , Limited Heterocykliczne pochodne metylosulfonu
WO2005016876A2 (en) 2003-08-08 2005-02-24 Schering Corporation Cyclic amine bace-1 inhibitors having a benzamide substituent
AR045219A1 (es) 2003-08-08 2005-10-19 Pharmacopeia Inc Aminas ciclicas inhibidoras de base - 1 que poseen un sustiuyente heterociclico
CA2544350A1 (en) 2003-10-29 2005-05-12 Elan Pharmaceuticals, Inc. N-substituted benzene sulfonamides
WO2005097768A2 (en) * 2004-04-05 2005-10-20 Schering Corporation Novel gamma secretase inhibitors
US20060035884A1 (en) * 2004-05-20 2006-02-16 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
PE20060481A1 (es) * 2004-06-30 2006-06-19 Schering Corp N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas
EP1768960A1 (en) * 2004-07-13 2007-04-04 F.Hoffmann-La Roche Ag Sulfonamide derivatives
CA2574218A1 (en) 2004-07-22 2006-02-09 Schering Corporation Substituted amide beta secretase inhibitors
US8143404B2 (en) 2004-09-13 2012-03-27 Ono Pharmaceutical Co., Ltd Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient
GB0423356D0 (en) * 2004-10-21 2004-11-24 Merck Sharp & Dohme Therapeutic agents
AU2006279312A1 (en) * 2005-08-19 2007-02-22 Elan Pharmaceuticals, Inc. Bridged N-cyclic sulfonamido inhibitors of gamma secretase
CA2644368A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
DK2041181T3 (da) * 2006-06-08 2011-08-29 Helmholtz Zentrum Muenchen Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi
RU2462464C2 (ru) * 2006-09-29 2012-09-27 Грюненталь Гмбх Замещенные сульфамидные производные
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101534824A (zh) * 2006-11-17 2009-09-16 艾博特公司 作为化学活素受体拮抗剂的氨基吡咯烷
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
US8080549B2 (en) * 2007-01-12 2011-12-20 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
AU2008256940A1 (en) * 2007-05-25 2008-12-04 Elan Pharmaceuticals, Inc. Pyrazolopyrrolidines as inhibitors of gamma secretase
JP2011523655A (ja) * 2008-06-03 2011-08-18 フレセニウス メディカル ケア ドイッチュランド ゲーエムベーハー ガンマセクレターゼモジュレータを含む医薬組成物
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
JP6478923B2 (ja) 2013-02-07 2019-03-06 ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ ムスカリンｍ４受容体アゴニストとしてのピペリジン−１−イル及びアゼピン−１−イルカルボキシレート
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387591A (en) * 1992-02-12 1995-02-07 Adir Et Compagnie Pyrrolidine compounds
WO2000058285A1 (en) * 1999-03-25 2000-10-05 F. Hoffmann-La Roche Ag 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of cns disorders
US6166037A (en) * 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
WO2002002554A1 (en) * 2000-06-30 2002-01-10 F. Hoffmann-La Roche Ag Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9800750D0 (en) * 1998-01-14 1998-03-11 Lilly Co Eli Pharmaceutical compound
GB9804426D0 (en) 1998-03-02 1998-04-29 Pfizer Ltd Heterocycles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387591A (en) * 1992-02-12 1995-02-07 Adir Et Compagnie Pyrrolidine compounds
US6166037A (en) * 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
WO2000058285A1 (en) * 1999-03-25 2000-10-05 F. Hoffmann-La Roche Ag 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of cns disorders
WO2002002554A1 (en) * 2000-06-30 2002-01-10 F. Hoffmann-La Roche Ag Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Org. Chem. 2001, 66, 1867-1875. *

Also Published As

Publication number Publication date
AR038482A1 (es) 2005-01-19
CA2478423A1 (en) 2003-08-14
JP2005522437A (ja) 2005-07-28
JP4758609B2 (ja) 2011-08-31
MY141504A (en) 2010-05-14
US20040048848A1 (en) 2004-03-11
US20060100427A1 (en) 2006-05-11
WO2003066592A1 (en) 2003-08-14
ECSP045218A (es) 2004-09-28
TW200302717A (en) 2003-08-16
PL371735A1 (en) 2005-06-27
ZA200406237B (en) 2005-09-22
KR20040081489A (ko) 2004-09-21
US7208602B2 (en) 2007-04-24
MXPA04007659A (es) 2005-06-08
RU2004126864A (ru) 2005-07-10
BR0307492A (pt) 2004-11-23
EP1472223A1 (en) 2004-11-03
NO20043696L (no) 2004-11-05
CN1628100A (zh) 2005-06-15
NZ534223A (en) 2007-05-31
CO5611195A2 (es) 2006-02-28
NO329067B1 (no) 2010-08-16
PE20030977A1 (es) 2003-12-04
AU2003210865A1 (en) 2003-09-02

Similar Documents

Publication Publication Date Title
AU2003210865B2 (en) Gamma secretase inhibitors
EP3481828B1 (en) Spiro-fused cyclic ureas as inhibitors of rock
CA2455863C (en) Tetrahydroquinoline derivatives as gamma secretase inhibitors
EP3548468B1 (en) Tricyclic rho kinase inhibitors
AU2004274449A1 (en) Novel gamma secretase inhibitors
EP3652165B1 (en) Five membered-aminoheterocyclic and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
WO2003013527A1 (en) Sulfonamide derivatives as gamma secretase inhibitors
AU2010220561A1 (en) Sulfonylated tetrahydroazolopyrazines and their use as medicinal products
CA2824536A1 (en) Protease activated receptor 2 (par2) antagonists
EP1789404B1 (en) Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors
EP2697232A1 (en) 6,7 - dihydroimidazo [2, 1 - b][1, 3]oxazine bactericides
EP3052099A1 (en) Novel pyrrolidine derived beta 3 adrenergic receptor agonists
EP2753623A1 (en) Gamma secretase inhibitors
NZ588589A (en) Novel class of spiro piperidines for the treatment of neurodegenerative diseases
JP2003509432A (ja) Ｄ４拮抗剤として有用なチエノイソキサゾリル−およびチエニルピラゾリル−フェノキシ置換プロピル誘導体
CA2607874A1 (en) Quinoline derivatives as neurokinin receptor antagonists
US8933116B2 (en) Gamma secretase inhibitors
US7838676B2 (en) Beta-secretase modulators and methods of use
WO2026039844A1 (en) Stat6 degraders and uses thereof
AU2006273796A1 (en) Quinoline derivatives as neurokinin receptor antagonists

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY,

Free format text: FORMER APPLICANT(S): SCHERING CORPORATION; PHARMACOPEIA, INC.

PC1 Assignment before grant (sect. 113)

Owner name: SCHERING CORPORATION; PHARMACOPEIA, INC.

Free format text: FORMER APPLICANT(S): SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired