PE20030121A1 - Derivados de quinazolina como promotores de la liberacion de hormona paratiroides (pt) - Google Patents
Derivados de quinazolina como promotores de la liberacion de hormona paratiroides (pt)Info
- Publication number
- PE20030121A1 PE20030121A1 PE2002000517A PE2002000517A PE20030121A1 PE 20030121 A1 PE20030121 A1 PE 20030121A1 PE 2002000517 A PE2002000517 A PE 2002000517A PE 2002000517 A PE2002000517 A PE 2002000517A PE 20030121 A1 PE20030121 A1 PE 20030121A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- isopropyl
- isopropil
- quinazolin
- ona
- Prior art date
Links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/88—Nicotinoylhydrazones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
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- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Neurosurgery (AREA)
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- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
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- Hematology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE AL USO DE COMPUESTOS BICICLICOS DE PREFERENCIA DERIVADOS DE 4-ARIL-2-(1H)-QUINAZOLINONA, DERIVADOS DE 4-ARIL-QUINAZOLINA 2- SUSTITUIDA DE FORMULA I, QUE TIENEN ACTIVIDAD ANTAGONISTA DEL RECEPTOR DE DETECCION DE CALCIO DE PARATIROIDES, DONDE -N(R2)=C(=R4); N=CHR4; NR2-CH(=Y); Y ES O, S; R1 ES OH, SH, HALOGENO, NO2, ALQUILO, ALCOXILO, ALQUENILO, ALQUENILOXILO, ALQUINILO, ENTRE OTROS; R2 ES H, ALQUILO, ARILO, ARILALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, ENTRE OTROS; R3 ES HALOGENO, ALQUILO, ALCOXILO, AMINO; R4' ES CIANO, HALOGENO,. AZIDA (N=N=N), ALQUILO, ALCOXILO, TIOALCOXILO, ARILOXILO, ARILALCOXILO, AMINO PARA EL TRATAMIENTO DE AGOTAMIENTO O RESORCION DE CALCIO. SON COMPUESTOS PREFERIDOS 1-ISOPROPIL-4-(4-ISOPROPIL-FENIL)-6-NITRO-1H-QUINAZOLIN-2-ONA; 6-AMINO-1-ISOPROPIL-4-(4-ISOPROPIL-FENIL)-1H-QUINAZOLIN-2-ONA; 6-DIALILAMINO-1-ISOPROPIL-4-(4-ISOPROPIL-FENIL)-1H-QUINAZOLIN-2-ONA; 6-ALILAMINO-1-ISOPROPIL-4-(4-ISOPROPIL-FENIL)1H-QUINAZOLIN-2-ONA; 6-DIMETILAMINO-1-ISOPROPIL-4-(4-ISOPROPIL-FENIL)-1H-QUINAZOLIN-2-ONA; (2-ISOPROPILAMINO-4,5-DIMETOXI-FENIL-(4-ISOPROPIL-FENIL)-METANONA, ENTRE OTROS. TAMBIEN SE REFIERE A COMPUESTOS DE FORMULA IV DONDE R1' ES H, OH, HALOGENO, ENTRE OTROS; R3' ES ALQUILO; R2" ES ARILALQUILO EXCEPTO LOS COMPUESTOS 1-BENCIL-4-FENIL-6-NITRO-2(1H)-QUINAZOLINA, 1-(2-PIRIDILMETIL)-4-FENIL-6-NITRO-2(1H)-QUINAZOLINA, ENTRE OTROS. TAMBIEN SE REFIERE A PROCESOS PARA LA PREPARACION
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0114702A GB0114702D0 (en) | 2001-06-15 | 2001-06-15 | Organic compounds |
GB0114701A GB0114701D0 (en) | 2001-06-15 | 2001-06-15 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
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PE20030121A1 true PE20030121A1 (es) | 2003-04-02 |
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ID=26246197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PE2002000517A PE20030121A1 (es) | 2001-06-15 | 2002-06-14 | Derivados de quinazolina como promotores de la liberacion de hormona paratiroides (pt) |
Country Status (31)
Country | Link |
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US (1) | US8476286B2 (es) |
EP (2) | EP1401451B1 (es) |
JP (2) | JP4118801B2 (es) |
KR (1) | KR100699959B1 (es) |
CN (1) | CN1516587A (es) |
AR (1) | AR038658A1 (es) |
AT (1) | ATE447958T1 (es) |
AU (1) | AU2002325242B2 (es) |
BR (1) | BR0210920A (es) |
CA (1) | CA2449234C (es) |
CO (1) | CO5550443A2 (es) |
CY (1) | CY1109767T1 (es) |
CZ (1) | CZ20033389A3 (es) |
DE (1) | DE60234341D1 (es) |
DK (1) | DK1401451T3 (es) |
ES (1) | ES2336197T3 (es) |
HU (1) | HUP0400205A3 (es) |
IL (2) | IL159000A0 (es) |
MX (1) | MXPA03011626A (es) |
MY (1) | MY145325A (es) |
NO (1) | NO326384B1 (es) |
NZ (1) | NZ529716A (es) |
PE (1) | PE20030121A1 (es) |
PL (1) | PL364474A1 (es) |
PT (1) | PT1401451E (es) |
RU (1) | RU2302244C2 (es) |
SI (1) | SI1401451T1 (es) |
SK (1) | SK287802B6 (es) |
TW (1) | TWI330179B (es) |
WO (1) | WO2002102782A2 (es) |
ZA (1) | ZA200309042B (es) |
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AR038658A1 (es) | 2001-06-15 | 2005-01-26 | Novartis Ag | Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento |
AU2007231842B2 (en) * | 2002-12-23 | 2011-04-14 | Novartis Ag | Derivatives of aryl-quinazoline/aryl-2-amino-phenyl methanone which promote the release of parathyroid hormone |
GB0230015D0 (en) * | 2002-12-23 | 2003-01-29 | Novartis Ag | Organic compounds |
TWI329628B (en) * | 2003-04-23 | 2010-09-01 | Japan Tobacco Inc | Casr antagonist |
DE102005022977A1 (de) | 2005-05-19 | 2006-12-07 | Merck Patent Gmbh | Phenylchinazolinderivate |
GB0511410D0 (en) * | 2005-06-03 | 2005-07-13 | James Black Foundation | Benzotrizepinone derivatives |
GB0516723D0 (en) * | 2005-08-15 | 2005-09-21 | Novartis Ag | Organic compounds |
GB0610018D0 (en) * | 2006-05-19 | 2006-06-28 | James Black Foundation | Benzotriazepinone derivatives |
KR100974081B1 (ko) * | 2008-07-24 | 2010-08-04 | 이화여자대학교 산학협력단 | 착탈식 치아 교정기구 |
EP2396316B1 (en) * | 2009-02-10 | 2015-07-01 | Janssen Pharmaceutica, N.V. | Quinazolinones as prolyl hydroxylase inhibitors |
TWI496782B (zh) | 2009-04-28 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | Spiro haloperidone derivatives |
MX344109B (es) | 2011-10-25 | 2016-12-05 | Janssen Pharmaceutica Nv | Formulaciones de sal de meglumina del ácido 1-(5,6-dicloro-1h-benz o[d]imidazol-2-il)-1h-pirazol-4-carboxílico. |
CA2892621C (en) * | 2012-12-10 | 2021-02-16 | Chugai Seiyaku Kabushiki Kaisha | Hydantoin derivative |
US9993462B2 (en) | 2014-06-09 | 2018-06-12 | Chugai Seiyaku Kabushiki Kaisha | Hydantoin derivative-containing pharmaceutical composition |
WO2021252680A1 (en) * | 2020-06-10 | 2021-12-16 | Ideaya Biosciences, Inc. | 4-arylquinazoline derivatives as methionine adenosyltransferase 2a inhibitors |
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2002
- 2002-06-13 AR ARP020102233A patent/AR038658A1/es unknown
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