DE60234341D1 - Chinazoline derivative zur förderung der freisetzung von parathyroidmshormonen - Google Patents

Chinazoline derivative zur förderung der freisetzung von parathyroidmshormonen

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Publication number
DE60234341D1
DE60234341D1 DE60234341T DE60234341T DE60234341D1 DE 60234341 D1 DE60234341 D1 DE 60234341D1 DE 60234341 T DE60234341 T DE 60234341T DE 60234341 T DE60234341 T DE 60234341T DE 60234341 D1 DE60234341 D1 DE 60234341D1
Authority
DE
Germany
Prior art keywords
chinazoline
derivative
promote
release
parathyroid hormones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60234341T
Other languages
English (en)
Inventor
Rene Beerli
Ruben Alberto Tommasi
Sven Weiler
Leo Widler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26246197&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60234341(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0114702A external-priority patent/GB0114702D0/en
Priority claimed from GB0114701A external-priority patent/GB0114701D0/en
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE60234341D1 publication Critical patent/DE60234341D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/88—Nicotinoylhydrazones
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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DE60234341T 2001-06-15 2002-06-14 Chinazoline derivative zur förderung der freisetzung von parathyroidmshormonen Expired - Lifetime DE60234341D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0114702A GB0114702D0 (en) 2001-06-15 2001-06-15 Organic compounds
GB0114701A GB0114701D0 (en) 2001-06-15 2001-06-15 Organic compounds
PCT/EP2002/006606 WO2002102782A2 (en) 2001-06-15 2002-06-14 QUINAZOLINE DERIVATIVES which PROMOTE THE RELEASE OF PARATHYROID_HORMONE

Publications (1)

Publication Number Publication Date
DE60234341D1 true DE60234341D1 (de) 2009-12-24

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DE60234341T Expired - Lifetime DE60234341D1 (de) 2001-06-15 2002-06-14 Chinazoline derivative zur förderung der freisetzung von parathyroidmshormonen

Country Status (31)

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US (1) US8476286B2 (de)
EP (2) EP1401451B1 (de)
JP (2) JP4118801B2 (de)
KR (1) KR100699959B1 (de)
CN (1) CN1516587A (de)
AR (1) AR038658A1 (de)
AT (1) ATE447958T1 (de)
AU (1) AU2002325242B2 (de)
BR (1) BR0210920A (de)
CA (1) CA2449234C (de)
CO (1) CO5550443A2 (de)
CY (1) CY1109767T1 (de)
CZ (1) CZ20033389A3 (de)
DE (1) DE60234341D1 (de)
DK (1) DK1401451T3 (de)
ES (1) ES2336197T3 (de)
HU (1) HUP0400205A3 (de)
IL (2) IL159000A0 (de)
MX (1) MXPA03011626A (de)
MY (1) MY145325A (de)
NO (1) NO326384B1 (de)
NZ (1) NZ529716A (de)
PE (1) PE20030121A1 (de)
PL (1) PL364474A1 (de)
PT (1) PT1401451E (de)
RU (1) RU2302244C2 (de)
SI (1) SI1401451T1 (de)
SK (1) SK287802B6 (de)
TW (1) TWI330179B (de)
WO (1) WO2002102782A2 (de)
ZA (1) ZA200309042B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR038658A1 (es) 2001-06-15 2005-01-26 Novartis Ag Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento
AU2007231842B2 (en) * 2002-12-23 2011-04-14 Novartis Ag Derivatives of aryl-quinazoline/aryl-2-amino-phenyl methanone which promote the release of parathyroid hormone
GB0230015D0 (en) * 2002-12-23 2003-01-29 Novartis Ag Organic compounds
TWI329628B (en) * 2003-04-23 2010-09-01 Japan Tobacco Inc Casr antagonist
DE102005022977A1 (de) 2005-05-19 2006-12-07 Merck Patent Gmbh Phenylchinazolinderivate
GB0511410D0 (en) * 2005-06-03 2005-07-13 James Black Foundation Benzotrizepinone derivatives
GB0516723D0 (en) * 2005-08-15 2005-09-21 Novartis Ag Organic compounds
GB0610018D0 (en) * 2006-05-19 2006-06-28 James Black Foundation Benzotriazepinone derivatives
KR100974081B1 (ko) * 2008-07-24 2010-08-04 이화여자대학교 산학협력단 착탈식 치아 교정기구
EP2396316B1 (de) * 2009-02-10 2015-07-01 Janssen Pharmaceutica, N.V. Chinazolinone als prolylhydroxylaseinhibitoren
TWI496782B (zh) 2009-04-28 2015-08-21 Chugai Pharmaceutical Co Ltd Spiro haloperidone derivatives
MX344109B (es) 2011-10-25 2016-12-05 Janssen Pharmaceutica Nv Formulaciones de sal de meglumina del ácido 1-(5,6-dicloro-1h-benz o[d]imidazol-2-il)-1h-pirazol-4-carboxílico.
CA2892621C (en) * 2012-12-10 2021-02-16 Chugai Seiyaku Kabushiki Kaisha Hydantoin derivative
US9993462B2 (en) 2014-06-09 2018-06-12 Chugai Seiyaku Kabushiki Kaisha Hydantoin derivative-containing pharmaceutical composition
WO2021252680A1 (en) * 2020-06-10 2021-12-16 Ideaya Biosciences, Inc. 4-arylquinazoline derivatives as methionine adenosyltransferase 2a inhibitors

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1195066A (en) * 1916-08-15 Traction whxel
US1313789A (en) * 1919-08-19 Puanookai h cu
US1353789A (en) * 1920-09-21 Window-venthiator
US1181570A (en) * 1911-03-18 1916-05-02 Churchward Internat Steel Company Alloyed steel.
US1046063A (en) * 1911-12-12 1912-12-03 Frederick H Felt Scale.
US1248428A (en) * 1917-06-26 1917-11-27 James Ferdinand Groom Roberts Cooking apparatus.
US3305553A (en) * 1965-10-18 1967-02-21 Parke Davis & Co 2-aminoquinazoline derivatives
CH487902A (de) * 1966-08-29 1970-03-31 Sandoz Ag Verfahren zur Herstellung von neuen Chinazolinonen
FR6001M (de) * 1966-12-02 1968-04-29
US3723432A (en) * 1968-11-12 1973-03-27 Sandoz Ag 1-substituted-4-aryl-2(1h)-quinazolinones and their preparation
BG16442A3 (bg) * 1967-10-30 1972-11-20 Max Denzer Метод за получаване на нови о-изопропиламинобензофенони
US3923803A (en) * 1968-07-18 1975-12-02 Sumitomo Chemical Co 2(1H)-Quinozalinones and process therefor
GB1251600A (de) 1968-07-18 1971-10-27
DE2037693C3 (de) * 1969-08-02 1975-01-16 Sumitomo Chemical Co., Ltd., Osaka (Japan) 1-Cyclopropylmethyl-2(1 H)-chinazolinonderivate
US3767797A (en) * 1969-08-02 1973-10-23 Sumitomo Chemical Co Novel quinazolinone derivatives as antiinflammatory and analgesic agents
JPS5118423B1 (de) 1970-12-08 1976-06-09
JPS5013271B2 (de) 1971-10-04 1975-05-19
BE790804A (fr) * 1971-11-18 1973-04-30 Sandoz Sa Procede de preparation de derives de la quinazoline
US3812257A (en) * 1972-04-07 1974-05-21 Sumitomo Chemical Co Uricosuric agent
JPS5418269B2 (de) * 1972-07-20 1979-07-06
JPS555506B2 (de) * 1972-09-07 1980-02-07
US3997564A (en) * 1973-04-13 1976-12-14 Sandoz, Inc. N-(3,4-methylenedioxy-phenyl)ureas
US4067868A (en) * 1973-04-17 1978-01-10 Sumitomo Chemical Company, Limited Production of quinazolinone compounds
JPS5046680A (de) 1973-08-20 1975-04-25
JPS518287A (en) 1974-07-13 1976-01-23 Sumitomo Chemical Co Kinazorinonjudotaioyobi sonoenno seizoho
JPS5125193A (en) * 1974-08-26 1976-03-01 Sumitomo Chemical Co Kinazorinjudotaino biryoteiryoho
JPS5251379A (en) * 1975-10-24 1977-04-25 Sumitomo Chem Co Ltd Preparation 3,4-dihydro-2(1h)-quinazoline derivates
JPS5271483A (en) * 1975-12-11 1977-06-14 Sumitomo Chem Co Ltd Synthesis of 2(1h)-quinazolinone derivatives
CH625512A5 (de) * 1976-12-13 1981-09-30 Sandoz Ag
US4171441A (en) * 1977-09-06 1979-10-16 Sandoz, Inc. Preparation of quinazolin-2(1H)-ones
JPS5795966A (en) 1980-12-04 1982-06-15 Sumitomo Chem Co Ltd Novel 2(1h)-quinazolinone derivative
TW232013B (de) 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
DE69422450T2 (de) * 1993-06-29 2000-06-08 Takeda Chemical Industries, Ltd. Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose
EP1203761B1 (de) * 1994-10-21 2005-01-19 Nps Pharmaceuticals, Inc. Kalzium-Rezeptor aktive Verbindungen
US5773663A (en) * 1996-05-01 1998-06-30 American Cyanamid Company Fungicidal methods, compounds and compositions containing benzophenones
DE19524398C1 (de) * 1995-07-04 1996-11-21 Adalbert Gubo Verfahren zum Archivieren von Dokumenten
CN1136547C (zh) * 1995-08-22 2004-01-28 松下电器产业株式会社 光盘记录和／或重放装置及设定记录功率及清除功率的方法
JPH11514361A (ja) * 1995-10-16 1999-12-07 藤沢薬品工業株式会社 Ｈ＋−ＡＴＰａｓｅとしての複素環式化合物
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
JPH11209350A (ja) 1998-01-26 1999-08-03 Eisai Co Ltd 含窒素複素環誘導体およびその医薬
US6358959B1 (en) 1999-01-26 2002-03-19 Merck & Co., Inc. Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
JP2001302515A (ja) 2000-04-18 2001-10-31 Sumitomo Pharmaceut Co Ltd ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤
US7173040B2 (en) 2000-09-25 2007-02-06 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives
JP4530552B2 (ja) * 2001-01-29 2010-08-25 富士通セミコンダクター株式会社 半導体装置及びその製造方法
AR038658A1 (es) * 2001-06-15 2005-01-26 Novartis Ag Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento
GB0230015D0 (en) 2002-12-23 2003-01-29 Novartis Ag Organic compounds
US7776035B2 (en) * 2004-10-08 2010-08-17 Covidien Ag Cool-tip combined electrode introducer

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