PE20020487A1 - Terapia antitumoral comprendiendo la administracion de derivados de la distamicina - Google Patents

Terapia antitumoral comprendiendo la administracion de derivados de la distamicina

Info

Publication number
PE20020487A1
PE20020487A1 PE2001000967A PE2001000967A PE20020487A1 PE 20020487 A1 PE20020487 A1 PE 20020487A1 PE 2001000967 A PE2001000967 A PE 2001000967A PE 2001000967 A PE2001000967 A PE 2001000967A PE 20020487 A1 PE20020487 A1 PE 20020487A1
Authority
PE
Peru
Prior art keywords
cancer
administration
cicaplotino
week
refers
Prior art date
Application number
PE2001000967A
Other languages
English (en)
Inventor
Camilla Fowst
Franzanne Vreeland
Maria Cristina Rosa Geroni
Original Assignee
Pharmacia & Upjohn Spa
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa, Upjohn Co filed Critical Pharmacia & Upjohn Spa
Publication of PE20020487A1 publication Critical patent/PE20020487A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

SE REFIERE AL USO DE UN DERIVADO DE O-HALOGENO-ACRILOIL DISTAMICINA DE FORMULA I DONDE R ES Br, Cl, PARA LA PREAPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE TUMORES GASTROINTESTINALES, CANCER COLORECTAL, CANCER GASTROESOFAGICO, CANCER DE HIGADO, QUE COMPRENDE LA INFUSION ENDOVENOSA POR 3-4 SEMANAS DE 0,85mg/m2 A 20mg/m2 DE AREA DE SUPERFICIECORPORAL O SEMANALMENTE POR 3 SEMANAS CONSECUTIVAS DE 0,3mg/m2/SEMANA A 7mg/m2/SEMANA; TAMBIEN SE REFIERE AL USO CON MELFALAN, CLORAMBUCIL, MECLORETAMINA, CICLOFOSFAMIDA, IFOSFAMIDA, BUSULFAN, CARMUSTINA, LORMUSTINA, SEMUSTINA, FOTEMUSTINA, DACARBAZIDA, TEMOZOLOMIDA, TIOPEDA, MITOMICINA C, CISPLATINO, CARBOPLATINO, OXALIPLATINO, NEDAPLATINO, CAMPTOTECINA, ENTRE OTROS
PE2001000967A 2000-10-02 2001-09-28 Terapia antitumoral comprendiendo la administracion de derivados de la distamicina PE20020487A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/676,770 US6576612B1 (en) 2000-10-02 2000-10-02 Antitumor therapy comprising distamycin derivatives

Publications (1)

Publication Number Publication Date
PE20020487A1 true PE20020487A1 (es) 2002-05-23

Family

ID=24715919

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000967A PE20020487A1 (es) 2000-10-02 2001-09-28 Terapia antitumoral comprendiendo la administracion de derivados de la distamicina

Country Status (24)

Country Link
US (2) US6576612B1 (es)
EP (1) EP1345604B1 (es)
JP (1) JP2004510734A (es)
KR (1) KR100827560B1 (es)
CN (1) CN1468099A (es)
AT (1) ATE339202T1 (es)
AU (2) AU2162202A (es)
BR (1) BR0114389A (es)
CA (1) CA2424116A1 (es)
CZ (1) CZ299686B6 (es)
DE (1) DE60123117T2 (es)
EA (1) EA006295B1 (es)
EE (1) EE05241B1 (es)
ES (1) ES2267841T3 (es)
HU (1) HUP0301247A2 (es)
IL (1) IL154755A0 (es)
MX (1) MXPA03002824A (es)
MY (1) MY134690A (es)
NO (1) NO20031410L (es)
PE (1) PE20020487A1 (es)
PL (1) PL363926A1 (es)
SK (1) SK5032003A3 (es)
WO (1) WO2002028389A1 (es)
ZA (1) ZA200303405B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015446D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
US20070249651A1 (en) * 2001-06-20 2007-10-25 Nerviano Medical Sciences S.R.I. Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6969592B2 (en) * 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
AU2003219102B2 (en) * 2002-04-02 2008-05-08 Nerviano Medical Sciences S.R.L. Combined therapy against tumors comprising subtituted acryloyl distamycin derivatives and radiotherapy
WO2004035045A1 (en) * 2002-10-16 2004-04-29 Pharmacia Italia S.P.A. Use of substituted acrylolyl distamycin derivatives in combination with demethylating agents, in the treatment of cancer
MX2008008470A (es) * 2005-12-27 2008-09-26 Univ Pais Vasco Nuevos derivados pirrolicos con actividad inhibidora de desacetilasa de histonas.
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Also Published As

Publication number Publication date
PL363926A1 (en) 2004-11-29
CZ2003909A3 (cs) 2003-08-13
MXPA03002824A (es) 2003-07-14
ZA200303405B (en) 2004-05-03
AU2002221622B2 (en) 2007-05-17
CA2424116A1 (en) 2002-04-11
IL154755A0 (en) 2003-10-31
SK5032003A3 (en) 2003-08-05
EA200300427A1 (ru) 2003-10-30
EA006295B1 (ru) 2005-10-27
WO2002028389A1 (en) 2002-04-11
NO20031410D0 (no) 2003-03-27
DE60123117T2 (de) 2007-02-08
ATE339202T1 (de) 2006-10-15
AU2162202A (en) 2002-04-15
BR0114389A (pt) 2004-02-03
EP1345604B1 (en) 2006-09-13
EE200300129A (et) 2003-06-16
MY134690A (en) 2007-12-31
EP1345604A1 (en) 2003-09-24
CZ299686B6 (cs) 2008-10-22
ES2267841T3 (es) 2007-03-16
EE05241B1 (et) 2009-12-15
KR20030096222A (ko) 2003-12-24
DE60123117D1 (de) 2006-10-26
US7399748B2 (en) 2008-07-15
US20040006023A1 (en) 2004-01-08
HUP0301247A2 (hu) 2003-09-29
NO20031410L (no) 2003-03-27
JP2004510734A (ja) 2004-04-08
US6576612B1 (en) 2003-06-10
KR100827560B1 (ko) 2008-05-07
CN1468099A (zh) 2004-01-14

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