PE20020083A1 - DERIVADOS DE DIPIRIDO[[3,2-b:2',3'-e][1,4] DIAZEPIN-6-ONA COMO INHIBIDORES DE LA TRANSCRIPTASA INVERSA - Google Patents

DERIVADOS DE DIPIRIDO[[3,2-b:2',3'-e][1,4] DIAZEPIN-6-ONA COMO INHIBIDORES DE LA TRANSCRIPTASA INVERSA

Info

Publication number
PE20020083A1
PE20020083A1 PE2001000560A PE2001000560A PE20020083A1 PE 20020083 A1 PE20020083 A1 PE 20020083A1 PE 2001000560 A PE2001000560 A PE 2001000560A PE 2001000560 A PE2001000560 A PE 2001000560A PE 20020083 A1 PE20020083 A1 PE 20020083A1
Authority
PE
Peru
Prior art keywords
methyl
diazepin
ona
ethyl
reverse transcriptase
Prior art date
Application number
PE2001000560A
Other languages
English (en)
Inventor
Bruno Simoneau
Original Assignee
Boehringer Ingelheim Ca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Ca Ltd
Publication of PE20020083A1 publication Critical patent/PE20020083A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE DIPIRIDO[[3,2-b:2',3'-e][1,4] DIAZEPIN-6-ONA DE FORMULA I DONDE R2 ES H, F, Cl, ALQUILO C1-C4, CICLOALQUILO C3-C4, CF3; R4 ES H, METILO; R5 ES H, METILO, ETILO CON LA CONDICION DE QUE R4 Y R5 NO SEAN AMBOS METILO Y SI R4 ES METILO, ENTONCES R5 NO PUEDE SER ETILO; R11 ES METILO, ETILO, CICLOPROPILO, PROPILO, ISOPROPILO, CICLOBUTILO; Q ES EL GRUPO a, GRUPO b, ENTRE OTROS.UN COMPUESTO PREFERIDO ES 5,11-DIHIDRO-11-ETIL-5-METIL-8-{2-(4-QUINOLINILOXI)ETIL}-6H-DIPIRIDO[3,2-b:2',3'-e][1,4]DIAZEPIN-6-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS DE FORMULA I SON INHIBIDORES DE LA TRANSCRIPTASA INVERSA Y SON UTILES PARA EL TRATAMIENTO DE INFECCION POR VIH
PE2001000560A 2000-06-16 2001-06-14 DERIVADOS DE DIPIRIDO[[3,2-b:2',3'-e][1,4] DIAZEPIN-6-ONA COMO INHIBIDORES DE LA TRANSCRIPTASA INVERSA PE20020083A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21232900P 2000-06-16 2000-06-16
US25663800P 2000-12-18 2000-12-18

Publications (1)

Publication Number Publication Date
PE20020083A1 true PE20020083A1 (es) 2002-02-28

Family

ID=26907019

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000560A PE20020083A1 (es) 2000-06-16 2001-06-14 DERIVADOS DE DIPIRIDO[[3,2-b:2',3'-e][1,4] DIAZEPIN-6-ONA COMO INHIBIDORES DE LA TRANSCRIPTASA INVERSA

Country Status (36)

Country Link
US (1) US6420359B1 (es)
EP (1) EP1294720B1 (es)
JP (1) JP3923894B2 (es)
KR (1) KR20030017540A (es)
CN (1) CN1178939C (es)
AR (1) AR028958A1 (es)
AT (1) ATE322492T1 (es)
AU (2) AU2001270370B2 (es)
BG (1) BG107348A (es)
BR (1) BR0102377A (es)
CA (1) CA2411766C (es)
CZ (1) CZ20024114A3 (es)
DE (1) DE60118560T2 (es)
DK (1) DK1294720T3 (es)
EA (1) EA005598B1 (es)
EE (1) EE200200690A (es)
ES (1) ES2261433T3 (es)
HK (1) HK1057558A1 (es)
HR (1) HRP20021003A2 (es)
HU (1) HUP0301105A2 (es)
IL (1) IL152819A0 (es)
MX (1) MXPA02012205A (es)
MY (1) MY130375A (es)
NO (1) NO323830B1 (es)
NZ (1) NZ523549A (es)
PE (1) PE20020083A1 (es)
PL (1) PL360370A1 (es)
PT (1) PT1294720E (es)
SA (1) SA01220202B1 (es)
SK (1) SK17722002A3 (es)
TW (1) TWI270547B (es)
UA (1) UA74834C2 (es)
UY (1) UY26767A1 (es)
WO (1) WO2001096338A1 (es)
YU (1) YU94202A (es)
ZA (1) ZA200209807B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716836B2 (en) 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US6673791B2 (en) 2001-07-30 2004-01-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US6706706B2 (en) 2002-03-27 2004-03-16 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US6806265B2 (en) * 2002-05-16 2004-10-19 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US6759533B2 (en) * 2002-06-28 2004-07-06 Boehringer Ingelheim Pharmaceuticals, Inc. Process and intermediates for making non-nucleoside HIV-1 reverse transcriptase inhibitors
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
JP2006511538A (ja) * 2002-12-16 2006-04-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 非ヌクレオシド系逆転写酵素阻害剤（ｎｎｒｔｉ）とプロテアーゼ阻害剤などのシトクロムｐ４５０の阻害剤とを含む組み合わせの使用
EP1610782A1 (en) * 2003-03-27 2006-01-04 Boehringer Ingelheim International GmbH Antiviral combination of a dipyridodiazepinone and a further antiretroviral compound
US7309700B2 (en) * 2004-04-02 2007-12-18 Boehringer Ingelheim International Gmbh Crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2′,3′-e] [1,4]diazepin-6-one
US20060025480A1 (en) 2004-08-02 2006-02-02 Boehringer Ingelheim International Gmbh Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors
US7151174B2 (en) * 2004-11-05 2006-12-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for making a non-nucleoside HIV-1 reverse transcriptase inhibitor
US7282583B2 (en) * 2005-12-05 2007-10-16 Boehringer Ingelheim International Gmbh Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
EP2085390A1 (en) * 2008-01-31 2009-08-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors
KR20120034592A (ko) * 2009-04-09 2012-04-12 베링거 인겔하임 인터내셔날 게엠베하 Ｈｉｖ 복제의 저해제

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5705499A (en) * 1995-10-06 1998-01-06 Boehringer Ingelheim Pharmaceuticals, Inc. 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection

Also Published As

Publication number Publication date
BR0102377A (pt) 2002-02-19
PT1294720E (pt) 2006-06-30
US6420359B1 (en) 2002-07-16
HRP20021003A2 (en) 2005-02-28
CA2411766C (en) 2006-05-23
CA2411766A1 (en) 2001-12-20
YU94202A (sh) 2005-11-28
CN1178939C (zh) 2004-12-08
AR028958A1 (es) 2003-05-28
NO323830B1 (no) 2007-07-09
EA005598B1 (ru) 2005-04-28
JP2004502787A (ja) 2004-01-29
CZ20024114A3 (cs) 2003-04-16
DE60118560T2 (de) 2006-09-28
US20020028807A1 (en) 2002-03-07
PL360370A1 (en) 2004-09-06
JP3923894B2 (ja) 2007-06-06
DE60118560D1 (de) 2006-05-18
HUP0301105A2 (hu) 2003-08-28
KR20030017540A (ko) 2003-03-03
ES2261433T3 (es) 2006-11-16
BG107348A (bg) 2004-06-30
UA74834C2 (en) 2006-02-15
AU2001270370B2 (en) 2006-08-03
EP1294720B1 (en) 2006-04-05
MXPA02012205A (es) 2003-09-10
NZ523549A (en) 2004-08-27
AU7037001A (en) 2001-12-24
HK1057558A1 (en) 2004-04-08
IL152819A0 (en) 2003-06-24
WO2001096338A1 (en) 2001-12-20
NO20025844D0 (no) 2002-12-05
EP1294720A1 (en) 2003-03-26
ATE322492T1 (de) 2006-04-15
NO20025844L (no) 2002-12-05
MY130375A (en) 2007-06-29
EA200201255A1 (ru) 2003-06-26
SK17722002A3 (sk) 2003-06-03
ZA200209807B (en) 2003-10-16
CN1436189A (zh) 2003-08-13
DK1294720T3 (da) 2006-07-31
TWI270547B (en) 2007-01-11
EE200200690A (et) 2004-06-15
SA01220202B1 (ar) 2006-09-05
UY26767A1 (es) 2002-01-31

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