AR028958A1 - INHIBIDORES DE TRANSCRIPTASA INVERSA NO NUCLEoSIDOS - Google Patents

INHIBIDORES DE TRANSCRIPTASA INVERSA NO NUCLEoSIDOS

Info

Publication number
AR028958A1
AR028958A1 ARP010102870A ARP010102870A AR028958A1 AR 028958 A1 AR028958 A1 AR 028958A1 AR P010102870 A ARP010102870 A AR P010102870A AR P010102870 A ARP010102870 A AR P010102870A AR 028958 A1 AR028958 A1 AR 028958A1
Authority
AR
Argentina
Prior art keywords
nucleosidos
formula
group
inhibitors
inverse
Prior art date
Application number
ARP010102870A
Other languages
English (en)
Inventor
Bruno Simoneau
Original Assignee
Boehringer Ingelheim Ca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Ca Ltd
Publication of AR028958A1 publication Critical patent/AR028958A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Se proporcionan compuestos de la formula general (1) en donde R2 se selecciona del grupo que consiste en H, F, Cl, alquilo (C1-4), cicloalquilo (C3-4) y CF3; R4 es H o Me; R5 es H, Me o Et, con la condicion de que R4 y R5 no sean ambos Me y si R4 es Me, entonces R5 no puede ser Et; R11 es Et, ciclopropilo, propilo, isopropilo o isobutilo; y Q se selecciona del grupo de formula (2) y sus sales farmacéuticamente aceptables, como inhibidores de la transcriptasa inversa de VIHH, cepas de tipo salvaje,y varias cepas mutantes. Una composicion farmacéutica que contiene al compuesto de formula (1)
ARP010102870A 2000-06-16 2001-06-15 INHIBIDORES DE TRANSCRIPTASA INVERSA NO NUCLEoSIDOS AR028958A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21232900P 2000-06-16 2000-06-16
US25663800P 2000-12-18 2000-12-18

Publications (1)

Publication Number Publication Date
AR028958A1 true AR028958A1 (es) 2003-05-28

Family

ID=26907019

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102870A AR028958A1 (es) 2000-06-16 2001-06-15 INHIBIDORES DE TRANSCRIPTASA INVERSA NO NUCLEoSIDOS

Country Status (36)

Country Link
US (1) US6420359B1 (es)
EP (1) EP1294720B1 (es)
JP (1) JP3923894B2 (es)
KR (1) KR20030017540A (es)
CN (1) CN1178939C (es)
AR (1) AR028958A1 (es)
AT (1) ATE322492T1 (es)
AU (2) AU7037001A (es)
BG (1) BG107348A (es)
BR (1) BR0102377A (es)
CA (1) CA2411766C (es)
CZ (1) CZ20024114A3 (es)
DE (1) DE60118560T2 (es)
DK (1) DK1294720T3 (es)
EA (1) EA005598B1 (es)
EE (1) EE200200690A (es)
ES (1) ES2261433T3 (es)
HK (1) HK1057558A1 (es)
HR (1) HRP20021003A2 (es)
HU (1) HUP0301105A2 (es)
IL (1) IL152819A0 (es)
MX (1) MXPA02012205A (es)
MY (1) MY130375A (es)
NO (1) NO323830B1 (es)
NZ (1) NZ523549A (es)
PE (1) PE20020083A1 (es)
PL (1) PL360370A1 (es)
PT (1) PT1294720E (es)
SA (1) SA01220202B1 (es)
SK (1) SK17722002A3 (es)
TW (1) TWI270547B (es)
UA (1) UA74834C2 (es)
UY (1) UY26767A1 (es)
WO (1) WO2001096338A1 (es)
YU (1) YU94202A (es)
ZA (1) ZA200209807B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716836B2 (en) 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US6673791B2 (en) 2001-07-30 2004-01-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US6706706B2 (en) 2002-03-27 2004-03-16 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US6806265B2 (en) * 2002-05-16 2004-10-19 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US6759533B2 (en) * 2002-06-28 2004-07-06 Boehringer Ingelheim Pharmaceuticals, Inc. Process and intermediates for making non-nucleoside HIV-1 reverse transcriptase inhibitors
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
CA2510143A1 (en) * 2002-12-16 2004-07-01 Boehringer Ingelheim International Gmbh Use of a combination containing a non-nucleoside reverse transcriptase inhibitor (nnrti) with an inhibitor of cytochrome p450, such as protease inhibitors
WO2004087140A1 (en) * 2003-03-27 2004-10-14 Boehringer Ingelheim International Gmbh Antiviral combination of a dipyridodiazepinone and a further antiretroviral compound
US7309700B2 (en) * 2004-04-02 2007-12-18 Boehringer Ingelheim International Gmbh Crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2′,3′-e] [1,4]diazepin-6-one
US20060025480A1 (en) 2004-08-02 2006-02-02 Boehringer Ingelheim International Gmbh Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors
US7151174B2 (en) * 2004-11-05 2006-12-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for making a non-nucleoside HIV-1 reverse transcriptase inhibitor
WO2007067844A1 (en) * 2005-12-05 2007-06-14 Boehringer Ingelheim International Gmbh Process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6h-di pyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
EP2085390A1 (en) * 2008-01-31 2009-08-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors
JP5643290B2 (ja) * 2009-04-09 2014-12-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｈｉｖ複製の阻害薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5705499A (en) * 1995-10-06 1998-01-06 Boehringer Ingelheim Pharmaceuticals, Inc. 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection

Also Published As

Publication number Publication date
PL360370A1 (en) 2004-09-06
HK1057558A1 (en) 2004-04-08
SK17722002A3 (sk) 2003-06-03
BR0102377A (pt) 2002-02-19
AU2001270370B2 (en) 2006-08-03
JP2004502787A (ja) 2004-01-29
ZA200209807B (en) 2003-10-16
KR20030017540A (ko) 2003-03-03
MXPA02012205A (es) 2003-09-10
ATE322492T1 (de) 2006-04-15
EA005598B1 (ru) 2005-04-28
US20020028807A1 (en) 2002-03-07
DE60118560T2 (de) 2006-09-28
HRP20021003A2 (en) 2005-02-28
CA2411766A1 (en) 2001-12-20
UY26767A1 (es) 2002-01-31
CZ20024114A3 (cs) 2003-04-16
ES2261433T3 (es) 2006-11-16
CA2411766C (en) 2006-05-23
SA01220202B1 (ar) 2006-09-05
HUP0301105A2 (hu) 2003-08-28
EA200201255A1 (ru) 2003-06-26
YU94202A (sh) 2005-11-28
PE20020083A1 (es) 2002-02-28
JP3923894B2 (ja) 2007-06-06
DE60118560D1 (de) 2006-05-18
EE200200690A (et) 2004-06-15
UA74834C2 (en) 2006-02-15
AU7037001A (en) 2001-12-24
EP1294720A1 (en) 2003-03-26
NO20025844L (no) 2002-12-05
US6420359B1 (en) 2002-07-16
WO2001096338A1 (en) 2001-12-20
NZ523549A (en) 2004-08-27
NO323830B1 (no) 2007-07-09
TWI270547B (en) 2007-01-11
CN1178939C (zh) 2004-12-08
DK1294720T3 (da) 2006-07-31
EP1294720B1 (en) 2006-04-05
MY130375A (en) 2007-06-29
BG107348A (bg) 2004-06-30
CN1436189A (zh) 2003-08-13
PT1294720E (pt) 2006-06-30
NO20025844D0 (no) 2002-12-05
IL152819A0 (en) 2003-06-24

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