PE20010983A1 - Forma de dosificacion de farmaco en capas impulsada por hidrogel - Google Patents

Forma de dosificacion de farmaco en capas impulsada por hidrogel

Info

Publication number
PE20010983A1
PE20010983A1 PE2000001381A PE0013812000A PE20010983A1 PE 20010983 A1 PE20010983 A1 PE 20010983A1 PE 2000001381 A PE2000001381 A PE 2000001381A PE 0013812000 A PE0013812000 A PE 0013812000A PE 20010983 A1 PE20010983 A1 PE 20010983A1
Authority
PE
Peru
Prior art keywords
sertraline
releases
weight
formulation
water
Prior art date
Application number
PE2000001381A
Other languages
English (en)
Inventor
Leah Elizabeth Appel
Ronald Arthur Beyerinck
Mark Brian Chidlaw
William John Curatolo
Kenneth Craig Waterman
Dwayne Thomas Friesen
Michael Christopher Roy
Danielle Supplee
Avinash Govind Thombre
Michael Bruce Fergione
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20010983A1 publication Critical patent/PE20010983A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UNA FORMA DE DOSIFICACION PARA LIBERACION CONTROLADA DE SERTRALINA QUE COMPRENDE 1)UN NUCLEO QUE CONTIENE a)SERTRALINA AL MENOS 20mgA, EN FORMA DE LACTATO, ACETATO, ASPARTATO; b)POLIMERO ARRASTRADOR; c)AGENTE FLUIDIZANTE; d)AGLUTINANTE; e)POLIMERO INTENSIFICADOR DE LA CONCENTRACION; f)SOLUBILIZADOR; g)UN ANTIOXIDANTE; h)POLIOXIDO DE ETILENO DE PESO MOLECULAR 500 000; CONSTITUYENDO 20%; b)UNA COMPOSICION HINCHABLE EN AGUA SITUADA EN UNA REGION SEPARADA DENTRO DEL NUCLEO; QUE NO CONTIENE AGENTE ACTIVO OSMOTICO; 2)UN REVESTIMIENTO EN TORNO A DICHO NUCLEO QUE ES PERMEABLE E INSOLUBLE AL AGUA; TIENE AL MENOS UNA ABERTURA DE SUMINISTRO A TRAVES DEL MISMO; DESPUES DE LA INTRODUCCION DE LA FORMULACION LIBERA SERTRALINA AL ENTORNO CON UNA VELOCIDAD MEDIA DE 6% A 10% EN PESO DESDE LA SEGUNDA HORA HASTA LA DUODECIMA HORA Y LIBERA MENOS DE 25% EN PESO DURANTE LAS 2 PRIMERA HORAS Y LIBERA AL MENOS EL 70% EN PESO AL CABO DE LA DUODECIMA HORA.LA FORMULACION SE GRANULA EN HUMEDO EMPLEANDO UNA MEZCLA DE ALCOHOL Y AGUA; LA FORMULACION LIBERA SERTRALINA A VELOCIDADES Y CANTIDADES DETERMINADAS CON EL FIN DE REDUCIR LA INCIDENCIA Y GRAVEDAD DE EFECTOS SECUNDARIOS QUE SE ORIGINA POR EL SUMINISTRO EXCESIVO DE SERTRALINA EN EL ESTOMAGO; INTENSIFICAN LA ABSORCION EN EL COLON, AUMENTAN LA CONCENTRACION DE SERTRALINA DISUELTA
PE2000001381A 1999-12-23 2000-12-21 Forma de dosificacion de farmaco en capas impulsada por hidrogel PE20010983A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17210899P 1999-12-23 1999-12-23

Publications (1)

Publication Number Publication Date
PE20010983A1 true PE20010983A1 (es) 2001-10-01

Family

ID=22626396

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001381A PE20010983A1 (es) 1999-12-23 2000-12-21 Forma de dosificacion de farmaco en capas impulsada por hidrogel

Country Status (15)

Country Link
US (1) US6899896B2 (es)
EP (1) EP1239839A2 (es)
JP (1) JP2003518487A (es)
AR (1) AR027066A1 (es)
AU (1) AU1724301A (es)
BR (1) BR0016707A (es)
CA (1) CA2395231C (es)
CO (1) CO5271728A1 (es)
GT (1) GT200000220A (es)
MX (1) MXPA02006335A (es)
PA (1) PA8508901A1 (es)
PE (1) PE20010983A1 (es)
TN (1) TNSN00251A1 (es)
UY (1) UY26493A1 (es)
WO (1) WO2001047498A2 (es)

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JP2004534812A (ja) 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク 薬物および中性ポリマーの分散物の医薬組成物
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JP2005523262A (ja) 2002-02-01 2005-08-04 ファイザー・プロダクツ・インク 薬物及び親油性ミクロ相形成物質の非晶質分散物の医薬組成物
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Also Published As

Publication number Publication date
JP2003518487A (ja) 2003-06-10
BR0016707A (pt) 2002-09-03
EP1239839A2 (en) 2002-09-18
CO5271728A1 (es) 2003-04-30
AR027066A1 (es) 2003-03-12
WO2001047498A3 (en) 2001-11-15
US6899896B2 (en) 2005-05-31
CA2395231C (en) 2006-08-15
UY26493A1 (es) 2001-07-31
MXPA02006335A (es) 2002-12-13
CA2395231A1 (en) 2001-07-05
GT200000220A (es) 2002-06-14
US20010044474A1 (en) 2001-11-22
PA8508901A1 (es) 2003-12-10
TNSN00251A1 (fr) 2002-05-30
AU1724301A (en) 2001-07-09
WO2001047498A2 (en) 2001-07-05

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