PE20001366A1 - Metodo para la preparacion de eteres de arilo - Google Patents
Metodo para la preparacion de eteres de ariloInfo
- Publication number
- PE20001366A1 PE20001366A1 PE1999001328A PE00132899A PE20001366A1 PE 20001366 A1 PE20001366 A1 PE 20001366A1 PE 1999001328 A PE1999001328 A PE 1999001328A PE 00132899 A PE00132899 A PE 00132899A PE 20001366 A1 PE20001366 A1 PE 20001366A1
- Authority
- PE
- Peru
- Prior art keywords
- reaction
- compound
- epoxide
- alcohol
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 7
- 238000006243 chemical reaction Methods 0.000 abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 150000002118 epoxides Chemical class 0.000 abstract 4
- -1 C1-C6 HALO-ALKYL Chemical class 0.000 abstract 3
- 241000670727 Amida Species 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 150000008378 aryl ethers Chemical class 0.000 abstract 2
- 150000002009 diols Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical class OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
- C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11409298P | 1998-12-29 | 1998-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001366A1 true PE20001366A1 (es) | 2000-11-19 |
Family
ID=22353332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001328A PE20001366A1 (es) | 1998-12-29 | 1999-12-28 | Metodo para la preparacion de eteres de arilo |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6376711B1 (enExample) |
| EP (2) | EP1140788B1 (enExample) |
| JP (1) | JP2002533430A (enExample) |
| KR (2) | KR100616386B1 (enExample) |
| CN (3) | CN100340552C (enExample) |
| AT (2) | ATE260238T1 (enExample) |
| AU (1) | AU764492B2 (enExample) |
| BR (1) | BR9916615A (enExample) |
| CA (1) | CA2349619A1 (enExample) |
| CO (1) | CO5140125A1 (enExample) |
| DE (2) | DE69940833D1 (enExample) |
| DK (1) | DK1140788T3 (enExample) |
| ES (1) | ES2214060T3 (enExample) |
| HK (1) | HK1041688B (enExample) |
| HU (1) | HUP0202144A3 (enExample) |
| IL (2) | IL161840A0 (enExample) |
| NZ (1) | NZ511452A (enExample) |
| PE (1) | PE20001366A1 (enExample) |
| PT (1) | PT1140788E (enExample) |
| SI (1) | SI1140788T1 (enExample) |
| TR (1) | TR200101885T2 (enExample) |
| TW (1) | TWI238155B (enExample) |
| WO (1) | WO2000039072A1 (enExample) |
| ZA (1) | ZA200103532B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796069B3 (fr) | 1999-07-09 | 2001-08-24 | Sanofi Synthelabo | Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes |
| AR030284A1 (es) | 2000-06-08 | 2003-08-20 | Merck & Co Inc | Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas |
| JP2007523153A (ja) * | 2004-02-20 | 2007-08-16 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | アリールエーテルの製造方法 |
| WO2005082869A1 (en) * | 2004-02-20 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Method for the preparation of aryl ethers |
| WO2005095435A1 (ja) * | 2004-03-31 | 2005-10-13 | Kuraray Co., Ltd. | プレグナン誘導体の製造方法 |
| AP2006003771A0 (en) | 2004-04-30 | 2006-10-31 | Warner Lambert Co | Substituted morpholine compounds for the treatmentof central nervous system disorders |
| GB0409744D0 (en) * | 2004-04-30 | 2004-06-09 | Pfizer Ltd | Novel compounds |
| GEP20125425B (en) | 2006-10-18 | 2012-03-26 | Pfizer Prod Inc | Biaryl ether urea compounds |
| US20100069389A1 (en) * | 2008-09-06 | 2010-03-18 | Bionevia Pharmaceuticals, Inc. | Novel forms of reboxetine |
| CN103804316A (zh) * | 2012-11-13 | 2014-05-21 | 天津药物研究院 | 一种（2RS,3RS）-6-[a-（2-乙氧基苯氧基）苄基]吗啉-3-酮（Ⅰ）的制备方法 |
| CN104557936A (zh) * | 2015-01-15 | 2015-04-29 | 河南科技学院 | 一种新型手性非环嘌呤核苷类似物的合成方法 |
| WO2019245975A1 (en) | 2018-06-17 | 2019-12-26 | Axsome Therapeutics, Inc. | Compositions for delivery of reboxetine |
| US11020402B2 (en) | 2018-10-15 | 2021-06-01 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
| US20200147093A1 (en) | 2018-10-15 | 2020-05-14 | Axsome Therapeutics, Inc. | Use of esreboxetine to treat nervous system disorders such as fibromyalgia |
| US12616702B2 (en) | 2019-12-03 | 2026-05-05 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
| US12565478B1 (en) | 2025-01-21 | 2026-03-03 | Axsome Therapeutics, Inc. | (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)-4-nitrosomorpholine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2785185A (en) * | 1952-08-07 | 1957-03-12 | Union Carbide & Carbon Corp | Process for making oxirane compounds from olefins and aldehyde monoperacylates |
| GB1053972A (enExample) * | 1962-08-30 | 1967-01-04 | ||
| IL56369A (en) * | 1978-01-20 | 1984-05-31 | Erba Farmitalia | Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them |
| GB8419683D0 (en) | 1984-08-02 | 1984-09-05 | Erba Farmitalia | 3-substituted derivatives of 1-amino-2-hydroxy-propane |
-
1999
- 1999-12-23 IL IL16184099A patent/IL161840A0/xx not_active IP Right Cessation
- 1999-12-23 IL IL14401299A patent/IL144012A/xx not_active IP Right Cessation
- 1999-12-23 US US09/469,429 patent/US6376711B1/en not_active Expired - Fee Related
- 1999-12-23 DE DE69940833T patent/DE69940833D1/de not_active Expired - Fee Related
- 1999-12-23 CN CNB2004100869263A patent/CN100340552C/zh not_active Expired - Fee Related
- 1999-12-23 DK DK99967557T patent/DK1140788T3/da active
- 1999-12-23 HU HU0202144A patent/HUP0202144A3/hu unknown
- 1999-12-23 DE DE69915110T patent/DE69915110T2/de not_active Expired - Fee Related
- 1999-12-23 PT PT99967557T patent/PT1140788E/pt unknown
- 1999-12-23 NZ NZ511452A patent/NZ511452A/xx unknown
- 1999-12-23 AU AU23819/00A patent/AU764492B2/en not_active Ceased
- 1999-12-23 EP EP99967557A patent/EP1140788B1/en not_active Expired - Lifetime
- 1999-12-23 AT AT99967557T patent/ATE260238T1/de not_active IP Right Cessation
- 1999-12-23 CN CNB998153028A patent/CN1308332C/zh not_active Expired - Fee Related
- 1999-12-23 SI SI9930559T patent/SI1140788T1/xx unknown
- 1999-12-23 CA CA002349619A patent/CA2349619A1/en not_active Abandoned
- 1999-12-23 JP JP2000590985A patent/JP2002533430A/ja active Pending
- 1999-12-23 BR BR9916615-1A patent/BR9916615A/pt not_active Application Discontinuation
- 1999-12-23 EP EP03002146A patent/EP1308443B1/en not_active Expired - Lifetime
- 1999-12-23 ES ES99967557T patent/ES2214060T3/es not_active Expired - Lifetime
- 1999-12-23 HK HK02103399.9A patent/HK1041688B/zh not_active IP Right Cessation
- 1999-12-23 KR KR1020017008269A patent/KR100616386B1/ko not_active Expired - Fee Related
- 1999-12-23 TR TR2001/01885T patent/TR200101885T2/xx unknown
- 1999-12-23 KR KR1020067014909A patent/KR100616029B1/ko not_active Expired - Fee Related
- 1999-12-23 AT AT03002146T patent/ATE430144T1/de not_active IP Right Cessation
- 1999-12-23 WO PCT/US1999/030748 patent/WO2000039072A1/en not_active Ceased
- 1999-12-23 CN CNB2004100323697A patent/CN1249038C/zh not_active Expired - Fee Related
- 1999-12-24 TW TW088122940A patent/TWI238155B/zh not_active IP Right Cessation
- 1999-12-28 PE PE1999001328A patent/PE20001366A1/es not_active Application Discontinuation
- 1999-12-28 CO CO99081078A patent/CO5140125A1/es unknown
-
2001
- 2001-05-02 ZA ZA200103532A patent/ZA200103532B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kazemi et al. | Chemoselective and scalable preparation of alkyl tosylates under solvent-free conditions | |
| US5780650A (en) | Process for preparation of 1,4-benzodioxane derivative | |
| GT199900216A (es) | Polimorfos de acido 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazol carboxilico y metodo de produccion de los mismos. | |
| ES2033423T3 (es) | Procedimientos para preparar derivados de 2-fenilpurinona. | |
| AR003472A1 (es) | Un procedimiento para preparar un alcohol terciario, un compuesto derivado de alfa-halo-alquil pirimidina y un compuesto intermediario para preparar 6-(1-bromoetil)-4-cloro-5-fluoropirimidina | |
| KR940007038A (ko) | 밀베마이신의 13-에테르 유도체의 제조방법 및 그의 중간체 | |
| PE20001562A1 (es) | Derivados de benzamida como inhibidores de la produccion hepatica de la apo proteina b-100 | |
| SE8106125L (sv) | 4,5-polymetylen-4-isotiazolin-3-oner, sett for framstellning derav och anvendning derav som baktericida och fungicida medel | |
| DK0547910T3 (da) | Fremgangsmåde til fremstilling af 2-chlor-2-deoxyadenosin | |
| PE20010962A1 (es) | Derivados de heterociclo-alquilsulfonil-pirazol como agentes anti-inflamatorios/analgesicos | |
| MX162343A (es) | Procedimiento para la preparacion de derivados de piridobenzotiazina | |
| ES2021941A6 (es) | Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles. | |
| AR048875A1 (es) | Un proceso para preparar montelukast y compuestos intermedios para el mismo | |
| ES8305755A1 (es) | Procedimiento para preparar derivados de pirimidona. | |
| KR890012982A (ko) | 치환된 1,2,4-트리아진디온, 이의 제조방법 및 용도 | |
| NZ511452A (en) | Method for the preparation of aryl ethers such as reboxetine | |
| DK518487A (da) | 7-(meta-substitueret phenylglycin)-1-carba-1-dethiacephalosporiner og fremgangsmaade til fremstilling heraf | |
| KR830007505A (ko) | 페닐알킬아민의 제조방법 | |
| KR880003889A (ko) | 나프탈렌 및 인단 유도체,이들 화합물을 함유하는 약제학적 조성물 및 그들의 제조 방법 | |
| ES8402557A1 (es) | Esteres fenolicos. | |
| AR006876A1 (es) | Procedimiento e intermedios para preparar el compuesto {2-(2-[1,2,4]- triazol-3-ilmetil)-1,2,3,4-tetrahidroisoquinolin-6-il} amida del acido 4'-trifluorometilbifenil-2-carboxilico | |
| DK458283D0 (da) | Fremgangsmade til fremstilling af phenylindenderivater eller syreadditionssalte deraf | |
| US5965753A (en) | Process for preparation of glycidyl sulfonate derivative | |
| ES8304976A1 (es) | "procedimiento para la preparacion de derivados triptaminicos sustituidos de tieniloxipropanolaminas, racemicos y opticamente activos". | |
| US5834507A (en) | Antineoplastic cyclolignan derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |