JP2002533430A - アリールエーテルの調製方法 - Google Patents

アリールエーテルの調製方法

Info

Publication number
JP2002533430A
JP2002533430A JP2000590985A JP2000590985A JP2002533430A JP 2002533430 A JP2002533430 A JP 2002533430A JP 2000590985 A JP2000590985 A JP 2000590985A JP 2000590985 A JP2000590985 A JP 2000590985A JP 2002533430 A JP2002533430 A JP 2002533430A
Authority
JP
Japan
Prior art keywords
formula
compound
alkyl
optionally substituted
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000590985A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002533430A5 (enExample
Inventor
ケビン・イー・ヘネガー
サラ・エリザベス・マンシーニ
キース・ダグラス・メイスト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of JP2002533430A publication Critical patent/JP2002533430A/ja
Publication of JP2002533430A5 publication Critical patent/JP2002533430A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2000590985A 1998-12-29 1999-12-23 アリールエーテルの調製方法 Pending JP2002533430A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11409298P 1998-12-29 1998-12-29
US60/114,092 1998-12-29
PCT/US1999/030748 WO2000039072A1 (en) 1998-12-29 1999-12-23 Method for the preparation of aryl ethers

Publications (2)

Publication Number Publication Date
JP2002533430A true JP2002533430A (ja) 2002-10-08
JP2002533430A5 JP2002533430A5 (enExample) 2006-08-17

Family

ID=22353332

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000590985A Pending JP2002533430A (ja) 1998-12-29 1999-12-23 アリールエーテルの調製方法

Country Status (24)

Country Link
US (1) US6376711B1 (enExample)
EP (2) EP1140788B1 (enExample)
JP (1) JP2002533430A (enExample)
KR (2) KR100616386B1 (enExample)
CN (3) CN100340552C (enExample)
AT (2) ATE260238T1 (enExample)
AU (1) AU764492B2 (enExample)
BR (1) BR9916615A (enExample)
CA (1) CA2349619A1 (enExample)
CO (1) CO5140125A1 (enExample)
DE (2) DE69940833D1 (enExample)
DK (1) DK1140788T3 (enExample)
ES (1) ES2214060T3 (enExample)
HK (1) HK1041688B (enExample)
HU (1) HUP0202144A3 (enExample)
IL (2) IL161840A0 (enExample)
NZ (1) NZ511452A (enExample)
PE (1) PE20001366A1 (enExample)
PT (1) PT1140788E (enExample)
SI (1) SI1140788T1 (enExample)
TR (1) TR200101885T2 (enExample)
TW (1) TWI238155B (enExample)
WO (1) WO2000039072A1 (enExample)
ZA (1) ZA200103532B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095435A1 (ja) * 2004-03-31 2005-10-13 Kuraray Co., Ltd. プレグナン誘導体の製造方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796069B3 (fr) 1999-07-09 2001-08-24 Sanofi Synthelabo Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes
AR030284A1 (es) 2000-06-08 2003-08-20 Merck & Co Inc Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas
JP2007523153A (ja) * 2004-02-20 2007-08-16 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー アリールエーテルの製造方法
WO2005082869A1 (en) * 2004-02-20 2005-09-09 Pharmacia & Upjohn Company Llc Method for the preparation of aryl ethers
AP2006003771A0 (en) 2004-04-30 2006-10-31 Warner Lambert Co Substituted morpholine compounds for the treatmentof central nervous system disorders
GB0409744D0 (en) * 2004-04-30 2004-06-09 Pfizer Ltd Novel compounds
GEP20125425B (en) 2006-10-18 2012-03-26 Pfizer Prod Inc Biaryl ether urea compounds
US20100069389A1 (en) * 2008-09-06 2010-03-18 Bionevia Pharmaceuticals, Inc. Novel forms of reboxetine
CN103804316A (zh) * 2012-11-13 2014-05-21 天津药物研究院 一种（2RS,3RS）-6-[a-（2-乙氧基苯氧基）苄基]吗啉-3-酮（Ⅰ）的制备方法
CN104557936A (zh) * 2015-01-15 2015-04-29 河南科技学院 一种新型手性非环嘌呤核苷类似物的合成方法
WO2019245975A1 (en) 2018-06-17 2019-12-26 Axsome Therapeutics, Inc. Compositions for delivery of reboxetine
US11020402B2 (en) 2018-10-15 2021-06-01 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy
US20200147093A1 (en) 2018-10-15 2020-05-14 Axsome Therapeutics, Inc. Use of esreboxetine to treat nervous system disorders such as fibromyalgia
US12616702B2 (en) 2019-12-03 2026-05-05 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy
US12565478B1 (en) 2025-01-21 2026-03-03 Axsome Therapeutics, Inc. (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)-4-nitrosomorpholine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785185A (en) * 1952-08-07 1957-03-12 Union Carbide & Carbon Corp Process for making oxirane compounds from olefins and aldehyde monoperacylates
GB1053972A (enExample) * 1962-08-30 1967-01-04
IL56369A (en) * 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
GB8419683D0 (en) 1984-08-02 1984-09-05 Erba Farmitalia 3-substituted derivatives of 1-amino-2-hydroxy-propane

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095435A1 (ja) * 2004-03-31 2005-10-13 Kuraray Co., Ltd. プレグナン誘導体の製造方法

Also Published As

Publication number Publication date
HUP0202144A2 (hu) 2002-11-28
DE69915110T2 (de) 2004-08-26
HK1041688A1 (en) 2002-07-19
CN1532194A (zh) 2004-09-29
HK1078572A1 (zh) 2006-03-17
US6376711B1 (en) 2002-04-23
ATE430144T1 (de) 2009-05-15
NZ511452A (en) 2002-11-26
CN1249038C (zh) 2006-04-05
KR20010099999A (ko) 2001-11-09
EP1140788B1 (en) 2004-02-25
CN100340552C (zh) 2007-10-03
TWI238155B (en) 2005-08-21
KR100616029B1 (ko) 2006-08-28
KR100616386B1 (ko) 2006-08-28
HK1066004A1 (en) 2005-03-11
BR9916615A (pt) 2001-10-23
HK1041688B (zh) 2007-12-07
ZA200103532B (en) 2002-08-02
EP1308443A2 (en) 2003-05-07
DE69940833D1 (de) 2009-06-10
PT1140788E (pt) 2004-07-30
IL144012A (en) 2005-11-20
ATE260238T1 (de) 2004-03-15
PE20001366A1 (es) 2000-11-19
KR20060090310A (ko) 2006-08-10
SI1140788T1 (en) 2004-08-31
EP1140788A1 (en) 2001-10-10
CN1332719A (zh) 2002-01-23
WO2000039072A1 (en) 2000-07-06
CA2349619A1 (en) 2000-07-06
IL161840A0 (en) 2005-11-20
CN1308332C (zh) 2007-04-04
HUP0202144A3 (en) 2003-10-28
CN1636988A (zh) 2005-07-13
IL144012A0 (en) 2002-04-21
EP1308443A3 (en) 2003-10-01
TR200101885T2 (tr) 2002-01-21
DK1140788T3 (da) 2004-06-07
DE69915110D1 (de) 2004-04-01
ES2214060T3 (es) 2004-09-01
EP1308443B1 (en) 2009-04-29
AU2381900A (en) 2000-07-31
CO5140125A1 (es) 2002-03-22
AU764492B2 (en) 2003-08-21

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