KR100616386B1 - 아릴 에테르의 제조 방법 - Google Patents

아릴 에테르의 제조 방법 Download PDF

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Publication number
KR100616386B1
KR100616386B1 KR1020017008269A KR20017008269A KR100616386B1 KR 100616386 B1 KR100616386 B1 KR 100616386B1 KR 1020017008269 A KR1020017008269 A KR 1020017008269A KR 20017008269 A KR20017008269 A KR 20017008269A KR 100616386 B1 KR100616386 B1 KR 100616386B1
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formula
compound
alkyl
optionally substituted
groups
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English (en)
Korean (ko)
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KR20010099999A (ko
Inventor
케빈 이. 헤네가
사라 엘리자베스 만치니
키이스 더글라스 마이스토
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파마시아 앤드 업존 캄파니 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020017008269A 1998-12-29 1999-12-23 아릴 에테르의 제조 방법 Expired - Fee Related KR100616386B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11409298P 1998-12-29 1998-12-29
US60/114,092 1998-12-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020067014909A Division KR100616029B1 (ko) 1998-12-29 1999-12-23 아릴 에테르의 제조 방법

Publications (2)

Publication Number Publication Date
KR20010099999A KR20010099999A (ko) 2001-11-09
KR100616386B1 true KR100616386B1 (ko) 2006-08-28

Family

ID=22353332

Family Applications (2)

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KR1020017008269A Expired - Fee Related KR100616386B1 (ko) 1998-12-29 1999-12-23 아릴 에테르의 제조 방법
KR1020067014909A Expired - Fee Related KR100616029B1 (ko) 1998-12-29 1999-12-23 아릴 에테르의 제조 방법

Family Applications After (1)

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KR1020067014909A Expired - Fee Related KR100616029B1 (ko) 1998-12-29 1999-12-23 아릴 에테르의 제조 방법

Country Status (24)

Country Link
US (1) US6376711B1 (enExample)
EP (2) EP1140788B1 (enExample)
JP (1) JP2002533430A (enExample)
KR (2) KR100616386B1 (enExample)
CN (3) CN100340552C (enExample)
AT (2) ATE260238T1 (enExample)
AU (1) AU764492B2 (enExample)
BR (1) BR9916615A (enExample)
CA (1) CA2349619A1 (enExample)
CO (1) CO5140125A1 (enExample)
DE (2) DE69940833D1 (enExample)
DK (1) DK1140788T3 (enExample)
ES (1) ES2214060T3 (enExample)
HK (1) HK1041688B (enExample)
HU (1) HUP0202144A3 (enExample)
IL (2) IL161840A0 (enExample)
NZ (1) NZ511452A (enExample)
PE (1) PE20001366A1 (enExample)
PT (1) PT1140788E (enExample)
SI (1) SI1140788T1 (enExample)
TR (1) TR200101885T2 (enExample)
TW (1) TWI238155B (enExample)
WO (1) WO2000039072A1 (enExample)
ZA (1) ZA200103532B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796069B3 (fr) 1999-07-09 2001-08-24 Sanofi Synthelabo Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes
AR030284A1 (es) 2000-06-08 2003-08-20 Merck & Co Inc Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas
JP2007523153A (ja) * 2004-02-20 2007-08-16 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー アリールエーテルの製造方法
WO2005082869A1 (en) * 2004-02-20 2005-09-09 Pharmacia & Upjohn Company Llc Method for the preparation of aryl ethers
WO2005095435A1 (ja) * 2004-03-31 2005-10-13 Kuraray Co., Ltd. プレグナン誘導体の製造方法
AP2006003771A0 (en) 2004-04-30 2006-10-31 Warner Lambert Co Substituted morpholine compounds for the treatmentof central nervous system disorders
GB0409744D0 (en) * 2004-04-30 2004-06-09 Pfizer Ltd Novel compounds
GEP20125425B (en) 2006-10-18 2012-03-26 Pfizer Prod Inc Biaryl ether urea compounds
US20100069389A1 (en) * 2008-09-06 2010-03-18 Bionevia Pharmaceuticals, Inc. Novel forms of reboxetine
CN103804316A (zh) * 2012-11-13 2014-05-21 天津药物研究院 一种（2RS,3RS）-6-[a-（2-乙氧基苯氧基）苄基]吗啉-3-酮（Ⅰ）的制备方法
CN104557936A (zh) * 2015-01-15 2015-04-29 河南科技学院 一种新型手性非环嘌呤核苷类似物的合成方法
WO2019245975A1 (en) 2018-06-17 2019-12-26 Axsome Therapeutics, Inc. Compositions for delivery of reboxetine
US11020402B2 (en) 2018-10-15 2021-06-01 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy
US20200147093A1 (en) 2018-10-15 2020-05-14 Axsome Therapeutics, Inc. Use of esreboxetine to treat nervous system disorders such as fibromyalgia
US12616702B2 (en) 2019-12-03 2026-05-05 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy
US12565478B1 (en) 2025-01-21 2026-03-03 Axsome Therapeutics, Inc. (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)-4-nitrosomorpholine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391735A (en) * 1984-08-02 1995-02-21 Farmitalia Carlo Erba S.P.A. Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785185A (en) * 1952-08-07 1957-03-12 Union Carbide & Carbon Corp Process for making oxirane compounds from olefins and aldehyde monoperacylates
GB1053972A (enExample) * 1962-08-30 1967-01-04
IL56369A (en) * 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391735A (en) * 1984-08-02 1995-02-21 Farmitalia Carlo Erba S.P.A. Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane

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Publication number Publication date
HUP0202144A2 (hu) 2002-11-28
DE69915110T2 (de) 2004-08-26
HK1041688A1 (en) 2002-07-19
CN1532194A (zh) 2004-09-29
HK1078572A1 (zh) 2006-03-17
US6376711B1 (en) 2002-04-23
JP2002533430A (ja) 2002-10-08
ATE430144T1 (de) 2009-05-15
NZ511452A (en) 2002-11-26
CN1249038C (zh) 2006-04-05
KR20010099999A (ko) 2001-11-09
EP1140788B1 (en) 2004-02-25
CN100340552C (zh) 2007-10-03
TWI238155B (en) 2005-08-21
KR100616029B1 (ko) 2006-08-28
HK1066004A1 (en) 2005-03-11
BR9916615A (pt) 2001-10-23
HK1041688B (zh) 2007-12-07
ZA200103532B (en) 2002-08-02
EP1308443A2 (en) 2003-05-07
DE69940833D1 (de) 2009-06-10
PT1140788E (pt) 2004-07-30
IL144012A (en) 2005-11-20
ATE260238T1 (de) 2004-03-15
PE20001366A1 (es) 2000-11-19
KR20060090310A (ko) 2006-08-10
SI1140788T1 (en) 2004-08-31
EP1140788A1 (en) 2001-10-10
CN1332719A (zh) 2002-01-23
WO2000039072A1 (en) 2000-07-06
CA2349619A1 (en) 2000-07-06
IL161840A0 (en) 2005-11-20
CN1308332C (zh) 2007-04-04
HUP0202144A3 (en) 2003-10-28
CN1636988A (zh) 2005-07-13
IL144012A0 (en) 2002-04-21
EP1308443A3 (en) 2003-10-01
TR200101885T2 (tr) 2002-01-21
DK1140788T3 (da) 2004-06-07
DE69915110D1 (de) 2004-04-01
ES2214060T3 (es) 2004-09-01
EP1308443B1 (en) 2009-04-29
AU2381900A (en) 2000-07-31
CO5140125A1 (es) 2002-03-22
AU764492B2 (en) 2003-08-21

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