PE20000360A1 - Aminoguanidinas ciclicas - Google Patents

Aminoguanidinas ciclicas

Info

Publication number
PE20000360A1
PE20000360A1 PE1999000232A PE00023299A PE20000360A1 PE 20000360 A1 PE20000360 A1 PE 20000360A1 PE 1999000232 A PE1999000232 A PE 1999000232A PE 00023299 A PE00023299 A PE 00023299A PE 20000360 A1 PE20000360 A1 PE 20000360A1
Authority
PE
Peru
Prior art keywords
alkyl
cyclic
heterocycle
aminoguanidine
imino
Prior art date
Application number
PE1999000232A
Other languages
English (en)
Inventor
Gerd Ascher
Josef Wieser
Werner Heilmayer
Johannes Hildebrandt
Michael Schranz
Johannes Ludescher
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of PE20000360A1 publication Critical patent/PE20000360A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS ANTIBACTERIALES QUE SON CEFALOSPORINAS DE 7-ACILAMINO-3-(AMINOGUANIDINACICLICA)METILENO; AMINOGUANIDINA-3-CICLICA; DE FORMULA I DONDE W ES CH, N; V ES CH, NO; R1 ES H, ACILO, CARBOXILO, ALQUILO; R3 ES H, UNA FRACCION DE ESTER; R2 ES UN GRUPO DE FORMULA a, b, c, ENTRE OTROS; X E Y SON ALQUILENO C2-C5, ALQUENILENO C2-C5; R4 ES H O ALQUILO; R5 ES H, ALQUILO, AMINOIMINOMETILO; R6 ES H, ALQUILO, CICLOALQUILO, AMINO, HIDROXI, ALCOXI, HETEROCICLO, -N=CHR8; R8 ES ALQUILO, ARILO, HETEROCICLO; R5 Y R6 FORMAN UN HETEROCICLO; R`6 ES ALQUILO, R7 ES H; R6 Y R7 FORMAN UN HETEROCICLO. UN COMPUESTO PREFERIDO ES ACIDO 7-{[(5-AMINO-1,2,4-TIADIAZOL-3-IL)-(Z)-(FLUOROMETOXI-IMINO)ACETIL]AMINO}-3-{[(3-ETIL-2-METILIMINO-IMIDAZOLIDIN-1-IL)IMINO]METIL}-3-CEFEM-4-CARBOXILICO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES PRODUCIDAS POR PSEUDOMONAS, ESCHERICHIA, ENTEROBACTER, KLEBSIELLA, ENTEROCOCCUS, MORAXELLA, STREPTOCOCCUS, STAPHYLOCOCCUS
PE1999000232A 1998-03-23 1999-03-22 Aminoguanidinas ciclicas PE20000360A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0051598A AT406772B (de) 1998-03-23 1998-03-23 Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
PE20000360A1 true PE20000360A1 (es) 2000-05-17

Family

ID=3492649

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000232A PE20000360A1 (es) 1998-03-23 1999-03-22 Aminoguanidinas ciclicas

Country Status (25)

Country Link
US (1) US6440957B1 (es)
EP (2) EP1930335A1 (es)
JP (1) JP2002507616A (es)
KR (1) KR100696422B1 (es)
CN (1) CN1188418C (es)
AR (1) AR015248A1 (es)
AT (1) AT406772B (es)
AU (1) AU749735B2 (es)
BR (1) BR9908960A (es)
CA (1) CA2324953C (es)
CO (1) CO5080739A1 (es)
HU (1) HUP0101603A3 (es)
ID (1) ID26567A (es)
IL (2) IL138477A0 (es)
MY (1) MY119841A (es)
NO (1) NO20004760L (es)
NZ (1) NZ506908A (es)
PE (1) PE20000360A1 (es)
PL (1) PL343094A1 (es)
RU (1) RU2245884C2 (es)
SK (1) SK14152000A3 (es)
TR (1) TR200002749T2 (es)
TW (1) TWI250983B (es)
WO (1) WO1999048896A1 (es)
ZA (1) ZA200004850B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115852A1 (en) * 1997-04-01 2002-08-22 Gerd Ascher Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
DE102007052891A1 (de) 2007-11-02 2009-05-07 Evonik Degussa Gmbh Verfahren zur Stabilisierung von olefinisch ungesättigten Monomeren
DE102013204950A1 (de) 2013-03-20 2014-09-25 Evonik Industries Ag Verfahren und Zusammensetzung zur Inhibierung der Polymerisation von Cyclopentadienverbindungen
EP2993164B1 (de) 2014-09-08 2017-02-15 Evonik Degussa GmbH Phenolische (Thio)Acetale als Inhibitoren der Polymerisation von olefinisch ungesättigten Monomeren
TWI669317B (zh) 2014-09-22 2019-08-21 德商贏創德固賽有限責任公司 反應性單體的改良製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE943408C (de) * 1953-03-31 1956-05-17 Bayer Ag Verfahren zur Darstellung von Bisguanylhydrazonen
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
CA2219656C (en) * 1995-05-11 2008-08-19 Gerd Ascher Antibacterial cephalosporins
PL200130B1 (pl) * 1997-04-01 2008-12-31 Nabriva Therapeutics Forschung Podstawione pochodne 7-acyloamino-3-(metylohydrazono)metylocefalosporyny, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca takie pochodne, zastosowania tych pochodnych oraz związki pośrednie służące do otrzymywania podstawionych 7-acyloamino-3-(metylohydrazono)metylocefalosporyn

Also Published As

Publication number Publication date
TWI250983B (en) 2006-03-11
RU2245884C2 (ru) 2005-02-10
EP1082326A1 (en) 2001-03-14
CN1188418C (zh) 2005-02-09
KR100696422B1 (ko) 2007-03-20
BR9908960A (pt) 2000-12-05
PL343094A1 (en) 2001-07-30
ZA200004850B (en) 2002-02-27
CO5080739A1 (es) 2001-09-25
IL138477A0 (en) 2001-10-31
NZ506908A (en) 2003-04-29
US6440957B1 (en) 2002-08-27
NO20004760L (no) 2000-11-21
EP1930335A1 (en) 2008-06-11
AU749735B2 (en) 2002-07-04
MY119841A (en) 2005-07-29
IL138477A (en) 2007-06-17
AR015248A1 (es) 2001-04-18
JP2002507616A (ja) 2002-03-12
AT406772B (de) 2000-08-25
SK14152000A3 (sk) 2001-05-10
TR200002749T2 (tr) 2000-12-21
KR20010074666A (ko) 2001-08-08
CN1294593A (zh) 2001-05-09
CA2324953A1 (en) 1999-09-30
ATA51598A (de) 2000-01-15
NO20004760D0 (no) 2000-09-22
AU3518899A (en) 1999-10-18
HUP0101603A2 (hu) 2001-12-28
CA2324953C (en) 2008-05-13
WO1999048896A1 (en) 1999-09-30
HUP0101603A3 (en) 2002-10-28
ID26567A (id) 2001-01-18

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed