PE133599A1 - Nuevos uretanos, sus analogos tio y ditio, sus sales, medicamentos que contienen estos compuestos y su empleo asi como procedimientos para su preparacion - Google Patents

Nuevos uretanos, sus analogos tio y ditio, sus sales, medicamentos que contienen estos compuestos y su empleo asi como procedimientos para su preparacion

Info

Publication number
PE133599A1
PE133599A1 PE1998001189A PE00118998A PE133599A1 PE 133599 A1 PE133599 A1 PE 133599A1 PE 1998001189 A PE1998001189 A PE 1998001189A PE 00118998 A PE00118998 A PE 00118998A PE 133599 A1 PE133599 A1 PE 133599A1
Authority
PE
Peru
Prior art keywords
alkynyl
alkyl
cholesterol
alkylene
refers
Prior art date
Application number
PE1998001189A
Other languages
English (en)
Inventor
Eisele Bernhard
Adelgos Gebhard
Schilcher Gebhard
Hurnaus Rudolf
Muller Peter
Maier Roland
Mark Michael
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE133599A1 publication Critical patent/PE133599A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A URETANOS DE FORMULA I DONDE: m ES 0-1; n ES 1-2; A ES ENLACE, ALQUILENO C1-C8, ALQUENILENO C2-C8, ALQUINILENO C2-C8, NO ESTA UNIDO A "Y" UN GRUPO INSATURADO; X ES O o S; Y ES O o S; R1 ES ALQUILO C1-C8, ALQUENILO C1-C6, ALQUINILO C1-C6; R2 ES H, ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO CON HIDROXI o ALCOXI; o R1 Y R2 JUNTO A N FORMAN UN ANILLO HETEROCICLICO DE 5-7 MIEMBROS; R3 A R6 SON H o ALQUILO; R7 ES ALQUILO C1-C6, ALQUENILO C1-C6, ALQUINILO C1-C6; R8 ES CICLOALQUILO C3-C7, FENILO, NAFTILO OPCIONALMENTE SUSTITUIDO, SI A NO ES UN ENLACE, ENTONCES ES H. UN COMPUESTO PREFERIDO ES TRANS-S-(4-CLOROFENIL)-N-4-[4-(DIMETILAMINOMETIL)FENIL]-CICLOHEXIL-N-METILDITIOCARBAMATO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS SUSTANCIAS ACTIVAS CON ACTIVIDAD REDUCTORA DEL COLESTEROL O LIPIDOS COMO RESINAS FIJADORAS DE ACIDOS BILIARES, COMPUESTOS QUE INHIBEN LA RESORCION DE COLESTEROL, FIBRATOS, ACIDO NICOTINICO. EL COMPUESTO I INHIBE A 2,3-EPOXIESCUALENO-LANOSTEROL-CICLASA QUE INTERVIENE EN LA BIOSINTESIS DEL COLESTEROL Y PUEDE SER UTIL PARA EL TRATAMIENTO DE HIPERCOLESTEROLEMIA, HIPERPROTEINEMIA, HIPERTRIGLICERIDEMIA, ATEROSCLEROSIS, MICOSIS; TAMBIEN SE LE EMPLEA COMO PIENSO PARA LAS GALLINAS PONEDORAS PARA PRODUCIR HUEVOS POBRES EN COLESTEROL
PE1998001189A 1997-12-10 1998-12-07 Nuevos uretanos, sus analogos tio y ditio, sus sales, medicamentos que contienen estos compuestos y su empleo asi como procedimientos para su preparacion PE133599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19754795A DE19754795A1 (de) 1997-12-10 1997-12-10 Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
PE133599A1 true PE133599A1 (es) 2000-01-13

Family

ID=7851380

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001189A PE133599A1 (es) 1997-12-10 1998-12-07 Nuevos uretanos, sus analogos tio y ditio, sus sales, medicamentos que contienen estos compuestos y su empleo asi como procedimientos para su preparacion

Country Status (30)

Country Link
US (1) US6346545B1 (es)
EP (1) EP1045832B1 (es)
JP (1) JP4001317B2 (es)
KR (1) KR20010024708A (es)
CN (1) CN1281431A (es)
AR (1) AR014405A1 (es)
AT (1) ATE291570T1 (es)
AU (1) AU747173B2 (es)
BG (1) BG104501A (es)
BR (1) BR9813545A (es)
CA (1) CA2310055C (es)
CO (1) CO5290251A1 (es)
CZ (1) CZ20002150A3 (es)
DE (2) DE19754795A1 (es)
EA (1) EA003298B1 (es)
EE (1) EE200000340A (es)
HR (1) HRP980621A2 (es)
HU (1) HUP0100292A3 (es)
ID (1) ID21432A (es)
IL (1) IL135737A0 (es)
NO (1) NO20002968L (es)
NZ (1) NZ505594A (es)
PE (1) PE133599A1 (es)
PL (1) PL341654A1 (es)
SK (1) SK8602000A3 (es)
TR (1) TR200001636T2 (es)
UY (1) UY25288A1 (es)
WO (1) WO1999029662A2 (es)
YU (1) YU35500A (es)
ZA (1) ZA9811263B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2715310A1 (en) * 2008-02-22 2009-08-27 Basf Se Fungicidal compositions comprising 3'-bromine-2,3,4,6'-tetramethoxy-2'-6-dimethylbenzophenone
EP2658544A4 (en) * 2010-12-27 2014-05-28 Univ Missouri OXIDOSQUALENZYCASE AS A PROTEINT ARGET FOR ANTICIPATED THERAPEUTICS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2025490C (en) * 1989-09-22 2003-09-16 James R. Mccarthy Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
US5011859A (en) * 1990-03-30 1991-04-30 Merrell Dow Pharmaceuticals Inc. Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase
CA2047375C (en) * 1990-07-25 2003-04-15 Charlotte L. Barney Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
US5466687A (en) 1992-10-22 1995-11-14 Dr. Karl Thomae Gmbh Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation
DE4303840A1 (de) * 1992-10-22 1994-08-11 Thomae Gmbh Dr K Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
DE4239150A1 (de) * 1992-11-20 1994-05-26 Thomae Gmbh Dr K O-Acyl-4-phenyl-cyclohexanole, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
DE4239151A1 (de) 1992-11-20 1994-05-26 Thomae Gmbh Dr K N,N-Disubstituierte Arylcycloalkylamine, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
DE4438020A1 (de) * 1994-10-25 1996-05-02 Thomae Gmbh Dr K N-substituierte Arylcyclohexylacylamine, ihre Salze mit physiologisch verträglichen organischen oder anorganischen Säuren, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
IL135737A0 (en) 2001-05-20
PL341654A1 (en) 2001-04-23
ZA9811263B (en) 2000-06-09
CN1281431A (zh) 2001-01-24
WO1999029662A3 (de) 1999-08-19
NO20002968L (no) 2000-08-09
JP4001317B2 (ja) 2007-10-31
EE200000340A (et) 2001-08-15
HRP980621A2 (en) 1999-08-31
JP2001525393A (ja) 2001-12-11
DE59812686D1 (de) 2005-04-28
TR200001636T2 (tr) 2001-08-21
EP1045832A2 (de) 2000-10-25
CA2310055A1 (en) 1999-06-17
HUP0100292A3 (en) 2002-11-28
ID21432A (id) 1999-06-10
EA003298B1 (ru) 2003-04-24
US6346545B1 (en) 2002-02-12
ATE291570T1 (de) 2005-04-15
CA2310055C (en) 2008-09-23
YU35500A (sh) 2002-09-19
AU1759399A (en) 1999-06-28
AR014405A1 (es) 2001-02-28
WO1999029662A2 (de) 1999-06-17
CZ20002150A3 (cs) 2001-11-14
EP1045832B1 (de) 2005-03-23
NZ505594A (en) 2001-11-30
CO5290251A1 (es) 2003-06-27
AU747173B2 (en) 2002-05-09
BG104501A (bg) 2001-03-30
EA200000633A1 (ru) 2000-12-25
HUP0100292A2 (hu) 2001-07-30
BR9813545A (pt) 2000-10-10
UY25288A1 (es) 2000-12-29
DE19754795A1 (de) 1999-06-17
SK8602000A3 (en) 2000-11-07
US20020019536A1 (en) 2002-02-14
NO20002968D0 (no) 2000-06-09
KR20010024708A (ko) 2001-03-26

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FG Grant, registration
FD Application declared void or lapsed