BR9813545A - Uretanos, seus análogos tio e ditio, seus sais, composições farmacêuticas contendo esses compostos e seu uso bem como o processo para preparar os mesmos - Google Patents

Uretanos, seus análogos tio e ditio, seus sais, composições farmacêuticas contendo esses compostos e seu uso bem como o processo para preparar os mesmos

Info

Publication number
BR9813545A
BR9813545A BR9813545-7A BR9813545A BR9813545A BR 9813545 A BR9813545 A BR 9813545A BR 9813545 A BR9813545 A BR 9813545A BR 9813545 A BR9813545 A BR 9813545A
Authority
BR
Brazil
Prior art keywords
salts
compounds
pharmaceutical compositions
compositions containing
urethanes
Prior art date
Application number
BR9813545-7A
Other languages
English (en)
Inventor
Roland Maier
Peter Mueller
Gebhard Adelgoss
Gebhard Schilcher
Rudolf Hurnaus
Michael Mark
Bernhard Eisele
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BR9813545A publication Critical patent/BR9813545A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Patente de Invenção: <B>"URETANOS, SEUS ANáLOGOS TIO E DITIO, SEUS SAIS, COMPOSIçõES FARMACêUTICAS CONTENDO ESSES COMPOSTOS E SEU USO BEM COMO O PROCESSO PARA PREPARAR OS MESMOS"<D>. A presente invenção refere-se a uretanos e aos seus análogos tio e ditio da fórmula geral em que m, n, A, X, Y e R¹ a R^ 8^ são definidos como na reivindicação 1, aos enanciómeros, diastereómeros e aos seus sais, particularmente seus sais de adição ácida aceitáveis fisiologicamente, que apresentam propriedades valiosas, particularmente um efeito inibitório na biossíntese do colesterol, a composições farmacêuticas contendo esses compostos, seu uso e aos processos para preparar os mesmos.
BR9813545-7A 1997-12-10 1998-12-08 Uretanos, seus análogos tio e ditio, seus sais, composições farmacêuticas contendo esses compostos e seu uso bem como o processo para preparar os mesmos BR9813545A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19754795A DE19754795A1 (de) 1997-12-10 1997-12-10 Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
PCT/EP1998/007962 WO1999029662A2 (de) 1997-12-10 1998-12-08 Urethane, ihre thio- und dithioanaloga, deren salze, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
BR9813545A true BR9813545A (pt) 2000-10-10

Family

ID=7851380

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813545-7A BR9813545A (pt) 1997-12-10 1998-12-08 Uretanos, seus análogos tio e ditio, seus sais, composições farmacêuticas contendo esses compostos e seu uso bem como o processo para preparar os mesmos

Country Status (30)

Country Link
US (1) US6346545B1 (pt)
EP (1) EP1045832B1 (pt)
JP (1) JP4001317B2 (pt)
KR (1) KR20010024708A (pt)
CN (1) CN1281431A (pt)
AR (1) AR014405A1 (pt)
AT (1) ATE291570T1 (pt)
AU (1) AU747173B2 (pt)
BG (1) BG104501A (pt)
BR (1) BR9813545A (pt)
CA (1) CA2310055C (pt)
CO (1) CO5290251A1 (pt)
CZ (1) CZ20002150A3 (pt)
DE (2) DE19754795A1 (pt)
EA (1) EA003298B1 (pt)
EE (1) EE200000340A (pt)
HR (1) HRP980621A2 (pt)
HU (1) HUP0100292A3 (pt)
ID (1) ID21432A (pt)
IL (1) IL135737A0 (pt)
NO (1) NO20002968L (pt)
NZ (1) NZ505594A (pt)
PE (1) PE133599A1 (pt)
PL (1) PL341654A1 (pt)
SK (1) SK8602000A3 (pt)
TR (1) TR200001636T2 (pt)
UY (1) UY25288A1 (pt)
WO (1) WO1999029662A2 (pt)
YU (1) YU35500A (pt)
ZA (1) ZA9811263B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091719A1 (es) * 2008-02-22 2009-12-11 Basf Se Composiciones fungicidas con 3'-bromo-2,3,4,6'-tetrametoxi-2',6-dimetilbenzofenona
EP2658544A4 (en) * 2010-12-27 2014-05-28 Univ Missouri OXIDOSQUALENZYCASE AS A PROTEINT ARGET FOR ANTICIPATED THERAPEUTICS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2025490C (en) * 1989-09-22 2003-09-16 James R. Mccarthy Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
US5011859A (en) * 1990-03-30 1991-04-30 Merrell Dow Pharmaceuticals Inc. Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase
ZA915659B (en) * 1990-07-25 1992-05-27 Merrell Dow Pharma Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
DE4303840A1 (de) * 1992-10-22 1994-08-11 Thomae Gmbh Dr K Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US5466687A (en) 1992-10-22 1995-11-14 Dr. Karl Thomae Gmbh Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation
DE4239150A1 (de) 1992-11-20 1994-05-26 Thomae Gmbh Dr K O-Acyl-4-phenyl-cyclohexanole, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
DE4239151A1 (de) * 1992-11-20 1994-05-26 Thomae Gmbh Dr K N,N-Disubstituierte Arylcycloalkylamine, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
DE4438020A1 (de) * 1994-10-25 1996-05-02 Thomae Gmbh Dr K N-substituierte Arylcyclohexylacylamine, ihre Salze mit physiologisch verträglichen organischen oder anorganischen Säuren, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
CO5290251A1 (es) 2003-06-27
WO1999029662A2 (de) 1999-06-17
KR20010024708A (ko) 2001-03-26
CA2310055C (en) 2008-09-23
CN1281431A (zh) 2001-01-24
EP1045832A2 (de) 2000-10-25
DE59812686D1 (de) 2005-04-28
HUP0100292A2 (hu) 2001-07-30
NO20002968L (no) 2000-08-09
EA200000633A1 (ru) 2000-12-25
ID21432A (id) 1999-06-10
ZA9811263B (en) 2000-06-09
AU747173B2 (en) 2002-05-09
AU1759399A (en) 1999-06-28
DE19754795A1 (de) 1999-06-17
ATE291570T1 (de) 2005-04-15
US6346545B1 (en) 2002-02-12
NZ505594A (en) 2001-11-30
SK8602000A3 (en) 2000-11-07
US20020019536A1 (en) 2002-02-14
BG104501A (bg) 2001-03-30
NO20002968D0 (no) 2000-06-09
JP4001317B2 (ja) 2007-10-31
WO1999029662A3 (de) 1999-08-19
UY25288A1 (es) 2000-12-29
YU35500A (sh) 2002-09-19
EE200000340A (et) 2001-08-15
EP1045832B1 (de) 2005-03-23
PE133599A1 (es) 2000-01-13
IL135737A0 (en) 2001-05-20
JP2001525393A (ja) 2001-12-11
HUP0100292A3 (en) 2002-11-28
TR200001636T2 (tr) 2001-08-21
EA003298B1 (ru) 2003-04-24
PL341654A1 (en) 2001-04-23
CA2310055A1 (en) 1999-06-17
CZ20002150A3 (cs) 2001-11-14
AR014405A1 (es) 2001-02-28
HRP980621A2 (en) 1999-08-31

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.