BR0311896A - Difenilazetidinonas substituìdas com grupos ácidos, processo para sua preparação, medicamentos contendo estes compostos e seu uso - Google Patents

Difenilazetidinonas substituìdas com grupos ácidos, processo para sua preparação, medicamentos contendo estes compostos e seu uso

Info

Publication number
BR0311896A
BR0311896A BR0311896-7A BR0311896A BR0311896A BR 0311896 A BR0311896 A BR 0311896A BR 0311896 A BR0311896 A BR 0311896A BR 0311896 A BR0311896 A BR 0311896A
Authority
BR
Brazil
Prior art keywords
compounds
preparing
processes
acid
drugs containing
Prior art date
Application number
BR0311896-7A
Other languages
English (en)
Inventor
Gerhard Jaehne
Wendelin Frick
Stefanie Flohr
Andreas Lindenschmidt
Heiner Glombik
Werner Kramer
Hubert Heuer
Hans-Ludwig Schaefer
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0311896A publication Critical patent/BR0311896A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Abstract

"DIFENILAZETIDINONAS SUBSTITUìDAS COM GRUPOS áCIDOS, PROCESSO PARA SUA PREPARAçãO, MEDICAMENTOS CONTENDO ESTES COMPOSTOS E SEU USO". A presente invenção refere-se a compostos da fórmula (1), em que R1, R2, R3, R4, R5 e R6 possuem os significados mencionados, bem como a seus sais fisiologicamente compatíveis. Os compostos são apropriados, por exemplo, como hipolididêmicos.
BR0311896-7A 2002-06-19 2003-06-04 Difenilazetidinonas substituìdas com grupos ácidos, processo para sua preparação, medicamentos contendo estes compostos e seu uso BR0311896A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10227508A DE10227508A1 (de) 2002-06-19 2002-06-19 Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
PCT/EP2003/005816 WO2004000805A1 (de) 2002-06-19 2003-06-04 Säuregruppen-substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Publications (1)

Publication Number Publication Date
BR0311896A true BR0311896A (pt) 2005-04-05

Family

ID=29719283

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311896-7A BR0311896A (pt) 2002-06-19 2003-06-04 Difenilazetidinonas substituìdas com grupos ácidos, processo para sua preparação, medicamentos contendo estes compostos e seu uso

Country Status (29)

Country Link
EP (1) EP1517891B1 (pt)
JP (1) JP2005533073A (pt)
KR (1) KR20050008835A (pt)
CN (1) CN100467448C (pt)
AR (1) AR039690A1 (pt)
AU (1) AU2003238210B2 (pt)
BR (1) BR0311896A (pt)
CA (1) CA2490112A1 (pt)
DE (1) DE10227508A1 (pt)
EC (1) ECSP045497A (pt)
HK (1) HK1079511A1 (pt)
HN (1) HN2003000185A (pt)
HR (1) HRPK20041201B3 (pt)
IL (1) IL165789A0 (pt)
MA (1) MA27206A1 (pt)
MX (1) MXPA04012093A (pt)
NO (1) NO20050134L (pt)
OA (1) OA12869A (pt)
PA (1) PA8576101A1 (pt)
PE (1) PE20040564A1 (pt)
PL (1) PL372700A1 (pt)
RS (1) RS108404A (pt)
RU (1) RU2287522C2 (pt)
SV (1) SV2004001548A (pt)
TN (1) TNSN04250A1 (pt)
TW (1) TW200413311A (pt)
UA (1) UA78577C2 (pt)
UY (1) UY27853A1 (pt)
WO (1) WO2004000805A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
SA04250427A (ar) 2003-12-23 2005-12-03 استرازينيكا ايه بي مشتقات ثاني فينيل أزيتيدون
CN102633730A (zh) 2004-12-03 2012-08-15 先灵公司 作为cb1拮抗剂的取代哌嗪
WO2006107936A1 (en) * 2005-04-04 2006-10-12 Pontificia Universidad Catolica De Chile The use of ezetimibe in the prevention and treatment of cholesterol gallstones
KR20080021082A (ko) 2005-06-20 2008-03-06 쉐링 코포레이션 히스타민 ｈ3 길항제로서 유용한 피페리딘 유도체
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
WO2007150010A2 (en) * 2006-06-23 2007-12-27 Abbott Laboratories Cyclopropyl amine derivatives as histamin h3 receptor modulators
CA2666193A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
DE102007002260A1 (de) 2007-01-16 2008-07-31 Sanofi-Aventis Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN101200443B (zh) * 2007-10-17 2011-06-29 中国药科大学 氮杂环丁酮衍生物、其制备方法及含有它们的药物组合
DE102007054497B3 (de) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
EP2310372B1 (en) 2008-07-09 2012-05-23 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CA2754384A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
EP2470552B1 (en) 2009-08-26 2013-11-13 Sanofi Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
DE10042447A1 (de) * 2000-08-29 2002-03-28 Aventis Pharma Gmbh Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports
CZ20031733A3 (cs) * 2000-12-21 2003-09-17 Aventis Pharma Deutschland Gmbh Difenylazetidinonové deriváty a farmaceutické prostředky s jejich obsahem
IL156550A0 (en) * 2000-12-21 2004-01-04 Aventis Pharma Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
IL156552A0 (en) * 2000-12-21 2004-01-04 Aventis Pharma Gmbh Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use

Also Published As

Publication number Publication date
SV2004001548A (es) 2004-03-19
RS108404A (en) 2007-02-05
AU2003238210A1 (en) 2004-01-06
PE20040564A1 (es) 2004-10-25
HN2003000185A (es) 2005-10-20
ECSP045497A (es) 2005-03-10
DE10227508A1 (de) 2004-01-08
HK1079511A1 (en) 2006-04-07
EP1517891A1 (de) 2005-03-30
IL165789A0 (en) 2006-01-15
AR039690A1 (es) 2005-03-09
MXPA04012093A (es) 2005-04-19
PA8576101A1 (es) 2004-02-07
HRPK20041201B3 (en) 2006-12-31
MA27206A1 (fr) 2005-01-03
CA2490112A1 (en) 2003-12-31
UY27853A1 (es) 2003-12-31
RU2005101093A (ru) 2005-07-20
AU2003238210B2 (en) 2008-10-23
NO20050134D0 (no) 2005-01-11
NO20050134L (no) 2005-03-18
HRP20041201A2 (en) 2005-08-31
KR20050008835A (ko) 2005-01-21
EP1517891B1 (de) 2013-04-03
JP2005533073A (ja) 2005-11-04
OA12869A (en) 2006-09-15
WO2004000805A1 (de) 2003-12-31
CN1662495A (zh) 2005-08-31
RU2287522C2 (ru) 2006-11-20
PL372700A1 (en) 2005-07-25
CN100467448C (zh) 2009-03-11
TW200413311A (en) 2004-08-01
UA78577C2 (en) 2007-04-10
TNSN04250A1 (en) 2007-03-12

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 8A ANUIDADE.