HUP0100292A2 - Új uretánok, tio- és ditio-analógjaik, sóik, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk és eljárás előállításukra - Google Patents
Új uretánok, tio- és ditio-analógjaik, sóik, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk és eljárás előállításukraInfo
- Publication number
- HUP0100292A2 HUP0100292A2 HU0100292A HUP0100292A HUP0100292A2 HU P0100292 A2 HUP0100292 A2 HU P0100292A2 HU 0100292 A HU0100292 A HU 0100292A HU P0100292 A HUP0100292 A HU P0100292A HU P0100292 A2 HUP0100292 A2 HU P0100292A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- chemical bond
- nitrogen
- alkenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000003673 urethanes Chemical class 0.000 title abstract 2
- 125000004119 disulfanediyl group Chemical group *SS* 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/14—Dithiocarbamic acids; Derivatives thereof
- C07C333/18—Esters of dithiocarbamic acids
- C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A találmány tárgyát az általános képletű új uretánok, tio- és ditio-analógjaik - ahol m 0 vagy l; n 1 vagy 2; A kémiai kötés, alkilén-,alkenilén- vagy alkiniléncsoport, ahol a telítetlen csoport nemközvetlenül az Y csoporthoz kapcsolódik; X O vagy S; Y O vagy S; R1alkil-, alkenil- vagy alkinilcsoport, ahol a többszörös kémiai kötés anitrogén-szén-kötéstől el van szigetelve; R2 H, alkilcsoport, amelyetegy OH vagy alkoxicsoport szubsztituálhat, alkenil- vagyalkinilcsoport, ahol egy OH és alkoxi-szubsztituens 1-től eltérőhelyzetben kapcsolódik, és a többszörös kémiai kötés a nitrogén-szén-kötéstől el van szigetelve; vagy R1 és R2 a közöttük levőnitrogénatommal együtt egy olyan 5-7 tagú telített heterociklusosgyűrűt képez, amelyben egy, a nitrogénatommal nem szomszédosmetiléncsoportot egy O vagy S, egy -NH-vagy -N(alkil)- képletű csoporthelyettesíthet; R3 - R6 egymástól függetlenül H vagy alkilcsoport; R7alkil-, alkenil- vagy alkinilcsoport, ahol a többszörös kémiai kötés anitrogén-szén-kötéstől el van szigetelve; R8 cikloalkil-, adottesetben szubsztituált fenil- vagy naftilcsoport, vagy ha A nemtelített kémiai kötés, úgy H is - fiziológiailag elfogadható szervesvagy szervetlen savakkal képzett sóik, eljárás előállításukra és azezeket a vegyületeket hatóanyagként tartalmazó, a koleszterinbioszintézist gátló gyógyszerkészítmények képezik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19754795A DE19754795A1 (de) | 1997-12-10 | 1997-12-10 | Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| PCT/EP1998/007962 WO1999029662A2 (de) | 1997-12-10 | 1998-12-08 | Urethane, ihre thio- und dithioanaloga, deren salze, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100292A2 true HUP0100292A2 (hu) | 2001-07-30 |
| HUP0100292A3 HUP0100292A3 (en) | 2002-11-28 |
Family
ID=7851380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100292A HUP0100292A3 (en) | 1997-12-10 | 1998-12-08 | Novel urethanes, thio and dithio analogues, the salts thereof, medicaments containing said compounds, use and method for the production thereof |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6346545B1 (hu) |
| EP (1) | EP1045832B1 (hu) |
| JP (1) | JP4001317B2 (hu) |
| KR (1) | KR20010024708A (hu) |
| CN (1) | CN1281431A (hu) |
| AR (1) | AR014405A1 (hu) |
| AT (1) | ATE291570T1 (hu) |
| AU (1) | AU747173B2 (hu) |
| BG (1) | BG104501A (hu) |
| BR (1) | BR9813545A (hu) |
| CA (1) | CA2310055C (hu) |
| CO (1) | CO5290251A1 (hu) |
| CZ (1) | CZ20002150A3 (hu) |
| DE (2) | DE19754795A1 (hu) |
| EA (1) | EA003298B1 (hu) |
| EE (1) | EE200000340A (hu) |
| HR (1) | HRP980621A2 (hu) |
| HU (1) | HUP0100292A3 (hu) |
| ID (1) | ID21432A (hu) |
| IL (1) | IL135737A0 (hu) |
| NO (1) | NO20002968L (hu) |
| NZ (1) | NZ505594A (hu) |
| PE (1) | PE133599A1 (hu) |
| PL (1) | PL341654A1 (hu) |
| SK (1) | SK8602000A3 (hu) |
| TR (1) | TR200001636T2 (hu) |
| UY (1) | UY25288A1 (hu) |
| WO (1) | WO1999029662A2 (hu) |
| YU (1) | YU35500A (hu) |
| ZA (1) | ZA9811263B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2715310A1 (en) * | 2008-02-22 | 2009-08-27 | Basf Se | Fungicidal compositions comprising 3'-bromine-2,3,4,6'-tetramethoxy-2'-6-dimethylbenzophenone |
| EP2658544A4 (en) * | 2010-12-27 | 2014-05-28 | Univ Missouri | OXIDOSQUALENZYCASE AS A PROTEINT ARGET FOR ANTICIPATED THERAPEUTICS |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2025490C (en) * | 1989-09-22 | 2003-09-16 | James R. Mccarthy | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis |
| US5011859A (en) * | 1990-03-30 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase |
| CA2047375C (en) * | 1990-07-25 | 2003-04-15 | Charlotte L. Barney | Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis |
| US5084461A (en) * | 1991-03-27 | 1992-01-28 | Merrell Dow Pharmaceuticals Inc. | Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis |
| US5466687A (en) | 1992-10-22 | 1995-11-14 | Dr. Karl Thomae Gmbh | Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation |
| DE4303840A1 (de) * | 1992-10-22 | 1994-08-11 | Thomae Gmbh Dr K | Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| DE4239150A1 (de) * | 1992-11-20 | 1994-05-26 | Thomae Gmbh Dr K | O-Acyl-4-phenyl-cyclohexanole, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| DE4239151A1 (de) | 1992-11-20 | 1994-05-26 | Thomae Gmbh Dr K | N,N-Disubstituierte Arylcycloalkylamine, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| DE4438020A1 (de) * | 1994-10-25 | 1996-05-02 | Thomae Gmbh Dr K | N-substituierte Arylcyclohexylacylamine, ihre Salze mit physiologisch verträglichen organischen oder anorganischen Säuren, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende Arzneimittel |
-
1997
- 1997-12-10 DE DE19754795A patent/DE19754795A1/de not_active Withdrawn
-
1998
- 1998-12-07 ID IDP981585A patent/ID21432A/id unknown
- 1998-12-07 UY UY25288A patent/UY25288A1/es unknown
- 1998-12-07 PE PE1998001189A patent/PE133599A1/es not_active Application Discontinuation
- 1998-12-08 IL IL13573798A patent/IL135737A0/xx unknown
- 1998-12-08 CZ CZ20002150A patent/CZ20002150A3/cs unknown
- 1998-12-08 KR KR1020007006319A patent/KR20010024708A/ko not_active Application Discontinuation
- 1998-12-08 SK SK860-2000A patent/SK8602000A3/sk unknown
- 1998-12-08 EE EEP200000340A patent/EE200000340A/xx unknown
- 1998-12-08 WO PCT/EP1998/007962 patent/WO1999029662A2/de active IP Right Grant
- 1998-12-08 EP EP98962422A patent/EP1045832B1/de not_active Expired - Lifetime
- 1998-12-08 TR TR2000/01636T patent/TR200001636T2/xx unknown
- 1998-12-08 EA EA200000633A patent/EA003298B1/ru not_active IP Right Cessation
- 1998-12-08 JP JP2000524259A patent/JP4001317B2/ja not_active Expired - Fee Related
- 1998-12-08 AT AT98962422T patent/ATE291570T1/de not_active IP Right Cessation
- 1998-12-08 PL PL98341654A patent/PL341654A1/xx not_active Application Discontinuation
- 1998-12-08 NZ NZ505594A patent/NZ505594A/en unknown
- 1998-12-08 DE DE59812686T patent/DE59812686D1/de not_active Expired - Lifetime
- 1998-12-08 CN CN98811960A patent/CN1281431A/zh active Pending
- 1998-12-08 CA CA002310055A patent/CA2310055C/en not_active Expired - Fee Related
- 1998-12-08 YU YU35500A patent/YU35500A/sh unknown
- 1998-12-08 HU HU0100292A patent/HUP0100292A3/hu unknown
- 1998-12-08 BR BR9813545-7A patent/BR9813545A/pt not_active IP Right Cessation
- 1998-12-08 AU AU17593/99A patent/AU747173B2/en not_active Ceased
- 1998-12-09 AR ARP980106227A patent/AR014405A1/es not_active Withdrawn
- 1998-12-09 CO CO98073124A patent/CO5290251A1/es not_active Application Discontinuation
- 1998-12-09 HR HR19754795.8A patent/HRP980621A2/hr not_active Application Discontinuation
- 1998-12-09 ZA ZA9811263A patent/ZA9811263B/xx unknown
-
1999
- 1999-03-24 US US09/275,318 patent/US6346545B1/en not_active Expired - Lifetime
-
2000
- 2000-06-02 BG BG104501A patent/BG104501A/bg active Pending
- 2000-06-09 NO NO20002968A patent/NO20002968L/no not_active Application Discontinuation
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