PA8789901A1 - Derivados de la 6-cicloamino-3-(piridazin-4-il)imidazol(1,2-b) priridazina, su preparación y su aplicación en terapéuta - Google Patents

Derivados de la 6-cicloamino-3-(piridazin-4-il)imidazol(1,2-b) priridazina, su preparación y su aplicación en terapéuta

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Publication number
PA8789901A1
PA8789901A1 PA20088789901A PA8789901A PA8789901A1 PA 8789901 A1 PA8789901 A1 PA 8789901A1 PA 20088789901 A PA20088789901 A PA 20088789901A PA 8789901 A PA8789901 A PA 8789901A PA 8789901 A1 PA8789901 A1 PA 8789901A1
Authority
PA
Panama
Prior art keywords
group
piridazin
derivatives
preparation
application
Prior art date
Application number
PA20088789901A
Other languages
English (en)
Inventor
Philippe Burnier
Adrien Tak Li
Frederic Puech
Des Combes Sylvain Cote
Yulin Chiang
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PA8789901A1 publication Critical patent/PA8789901A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE LA 6-CICLOAMINO-3-(PIRIDAZIN-4-IL)IMIDAZO[1,2-B]PIRIDAZINA, DE FÓRMULA GENERAL (I): EN LA QUE R2 REPRESENTA UN GRUPO ARILO OPCIONALMENTE SUSTITUIDO; A REPRESENTA UN GRUPO ALQUILENO C1-7 OPCIONALMENTE SUSTITUIDO; B REPRESENTA UN GRUPO ALQUILENO C1-7 OPCIONALMENTE SUSTITUIDO; L REPRESENTA BIEN UN ÁTOMO DE NITRÓGENO OPCIONALMENTE SUSTITUIDO CON UN GRUPO RC O RD, O BIEN UN ÁTOMO DE CARBONO SUSTITUIDO CON UN GRUPO RE1 Y UN GRUPO RD O DOS GRUPOS RE2, ESTANDO LOS ÁTOMOS DE CARBONO A Y DE B OPCIONALMENTE SUSTITUIDOS CON UNO O VARIOS GRUPOS RF IDÉNTICOS O DIFERENTES EL UNO DEL OTRO; R7 Y R8 REPRESENTAN, INDEPENDIENTEMENTE EL UNO DEL OTRO, UN ÁTOMO DE HIDRÓGENO O UN GRUPO ALQUILO C1-6. PROCEDIMIENTO DE PREPARACIÓN Y APLICACIÓN EN TERAPÉUTICA.
PA20088789901A 2007-07-19 2008-07-15 Derivados de la 6-cicloamino-3-(piridazin-4-il)imidazol(1,2-b) priridazina, su preparación y su aplicación en terapéuta PA8789901A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95071107P 2007-07-19 2007-07-19
FR0705224A FR2918986B1 (fr) 2007-07-19 2007-07-19 Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PA8789901A1 true PA8789901A1 (es) 2009-02-09

Family

ID=39183122

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088789901A PA8789901A1 (es) 2007-07-19 2008-07-15 Derivados de la 6-cicloamino-3-(piridazin-4-il)imidazol(1,2-b) priridazina, su preparación y su aplicación en terapéuta

Country Status (22)

Country Link
US (2) US8455491B2 (es)
EP (1) EP2178879B1 (es)
JP (1) JP5431319B2 (es)
KR (1) KR20100041771A (es)
CN (1) CN101784552A (es)
AR (1) AR069272A1 (es)
AU (1) AU2008300449A1 (es)
BR (1) BRPI0814510A2 (es)
CA (1) CA2693116A1 (es)
CL (1) CL2008002138A1 (es)
CO (1) CO6290690A2 (es)
EA (1) EA016376B1 (es)
ES (1) ES2429765T3 (es)
FR (1) FR2918986B1 (es)
MA (1) MA31616B1 (es)
NZ (1) NZ582683A (es)
PA (1) PA8789901A1 (es)
PE (1) PE20090493A1 (es)
TW (1) TW200914456A (es)
UY (1) UY31236A1 (es)
WO (1) WO2009037394A2 (es)
ZA (1) ZA201001214B (es)

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BRPI0814294A2 (pt) 2007-07-19 2015-02-03 Metabolex Inc Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas.
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FR2940285A1 (fr) 2008-12-19 2010-06-25 Sanofi Aventis Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940284B1 (fr) * 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
WO2011041154A1 (en) 2009-10-01 2011-04-07 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
JP5848251B2 (ja) 2009-10-23 2016-01-27 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての縮合複素環式化合物
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JP5181156B2 (ja) 2010-08-09 2013-04-10 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
ES2553610T3 (es) * 2010-12-14 2015-12-10 Electrophoretics Limited Inhibidores de la caseína cinasa 1 delta (CK1delta)
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BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
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Also Published As

Publication number Publication date
JP5431319B2 (ja) 2014-03-05
BRPI0814510A2 (pt) 2015-02-03
FR2918986B1 (fr) 2009-09-04
CA2693116A1 (fr) 2009-03-26
TW200914456A (en) 2009-04-01
WO2009037394A3 (fr) 2009-06-18
CL2008002138A1 (es) 2009-10-23
AR069272A1 (es) 2010-01-13
EP2178879B1 (fr) 2013-07-03
KR20100041771A (ko) 2010-04-22
ZA201001214B (en) 2011-05-25
WO2009037394A2 (fr) 2009-03-26
ES2429765T3 (es) 2013-11-15
US20130245023A1 (en) 2013-09-19
FR2918986A1 (fr) 2009-01-23
US8455491B2 (en) 2013-06-04
US9108971B2 (en) 2015-08-18
EA201070161A1 (ru) 2010-08-30
US20100152157A1 (en) 2010-06-17
MA31616B1 (fr) 2010-08-02
CN101784552A (zh) 2010-07-21
EA016376B1 (ru) 2012-04-30
EP2178879A2 (fr) 2010-04-28
UY31236A1 (es) 2009-03-02
NZ582683A (en) 2011-07-29
JP2010533686A (ja) 2010-10-28
CO6290690A2 (es) 2011-06-20
AU2008300449A1 (en) 2009-03-26
PE20090493A1 (es) 2009-05-27

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