AR076665A1 - Derivados de 2-cicloamino-5-(piridin-4-il)imidazo(2,1-b)(1,3,4)tiadiazol su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de 2-cicloamino-5-(piridin-4-il)imidazo(2,1-b)(1,3,4)tiadiazol su preparacion y su aplicacion en terapeutica

Info

Publication number
AR076665A1
AR076665A1 ARP100101581A ARP100101581A AR076665A1 AR 076665 A1 AR076665 A1 AR 076665A1 AR P100101581 A ARP100101581 A AR P100101581A AR P100101581 A ARP100101581 A AR P100101581A AR 076665 A1 AR076665 A1 AR 076665A1
Authority
AR
Argentina
Prior art keywords
group
optionally substituted
imidazo
therapeutics
derivatives
Prior art date
Application number
ARP100101581A
Other languages
English (en)
Inventor
Romain Oudot
Christophe Pacaud
Frederic Puech
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR076665A1 publication Critical patent/AR076665A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a derivados de 2-cicloamino-5-(piridin-4-il)imidazo[2,1-b][1,3,4]tiadiazol de formula general (1) en la que; R5 representa un átomo de hidrogeno o un grupo alquilo C1-3, -NR7R8, o alquiloxi C1-3, R6 representa un grupo fenilo opcionalmente sustituido; A representa un grupo alquileno C1-7 opcionalmente sustituido con uno o dos grupos Ra; B representa un grupo alquileno C1-7 opcionalmente sustituido con un grupo Rb; L representa bien un átomo de nitrogeno opcionalmente sustituido con un grupo Rc o Rd, o bien un átomo de carbono sustituido con un grupo Re1, y un grupo Rd o dos grupos Re2; R7 y R8 representan, independientemente uno de otro, un átomo de hidrogeno o un grupo alquilo C1-3. Procedimiento de preparacion y aplicacion en terapéutica.
ARP100101581A 2009-05-11 2010-05-10 Derivados de 2-cicloamino-5-(piridin-4-il)imidazo(2,1-b)(1,3,4)tiadiazol su preparacion y su aplicacion en terapeutica AR076665A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0902248A FR2945289A1 (fr) 2009-05-11 2009-05-11 Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR076665A1 true AR076665A1 (es) 2011-06-29

Family

ID=41404111

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101581A AR076665A1 (es) 2009-05-11 2010-05-10 Derivados de 2-cicloamino-5-(piridin-4-il)imidazo(2,1-b)(1,3,4)tiadiazol su preparacion y su aplicacion en terapeutica

Country Status (3)

Country Link
AR (1) AR076665A1 (es)
FR (1) FR2945289A1 (es)
WO (1) WO2010130934A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2651404B1 (en) * 2010-12-14 2015-10-14 Electrophoretics Limited Casein kinase 1delta (ck1delta) inhibitors
CA3119019C (en) 2015-12-10 2024-06-11 Ptc Therapeutics, Inc. Compounds and methods for treating huntington's disease
SG11201911615WA (en) 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
BR112019027717A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
US11395822B2 (en) 2017-06-28 2022-07-26 Ptc Therapeutics, Inc. Methods for treating Huntington's disease
US12103926B2 (en) 2018-03-27 2024-10-01 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
US11685746B2 (en) 2018-06-27 2023-06-27 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
LT3814357T (lt) 2018-06-27 2024-06-25 Ptc Therapeutics, Inc. Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
KR20240101561A (ko) 2021-10-14 2024-07-02 인사이트 코포레이션 Kras의 저해제로서의 퀴놀린 화합물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637271A (es) * 1963-04-04 1900-01-01
US5552422A (en) * 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
NZ507032A (en) 1998-03-19 2003-06-30 Pharmacia & Upjohn 1,3,4-thiadiazoles useful for the treatment of herpes and cytomegalovirus infections
PA8595001A1 (es) * 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
CA2549183A1 (en) 2003-12-11 2005-07-07 Aventis Pharmaceuticals Inc. Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon
WO2006040569A1 (en) 2004-10-14 2006-04-20 Astex Therapeutics Limited Thiophene amide compounds for use in the treatment or prophylaxis of cancers
EP2180893B1 (en) * 2007-08-09 2014-11-12 Urifer Ltd Pharmaceutical compositions and methods for the treatment of cancer
SI2193133T1 (sl) * 2007-09-27 2015-12-31 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Imidazolotiadiazoli za uporabo kot zaviralci protein-kinaze

Also Published As

Publication number Publication date
WO2010130934A3 (fr) 2011-01-06
WO2010130934A2 (fr) 2010-11-18
FR2945289A1 (fr) 2010-11-12

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