OA12324A - Novel method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. - Google Patents

Novel method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. Download PDF

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Publication number
OA12324A
OA12324A OA1200200303A OA1200200303A OA12324A OA 12324 A OA12324 A OA 12324A OA 1200200303 A OA1200200303 A OA 1200200303A OA 1200200303 A OA1200200303 A OA 1200200303A OA 12324 A OA12324 A OA 12324A
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OA
OAPI
Prior art keywords
formula
synthesis
compound
process according
perindopril
Prior art date
Application number
OA1200200303A
Other languages
English (en)
Inventor
Jean-Claude Souvie
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of OA12324A publication Critical patent/OA12324A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
OA1200200303A 2000-03-31 2001-03-30 Novel method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. OA12324A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0004112A FR2807037B1 (fr) 2000-03-31 2000-03-31 NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL

Publications (1)

Publication Number Publication Date
OA12324A true OA12324A (en) 2006-05-12

Family

ID=8848711

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200303A OA12324A (en) 2000-03-31 2001-03-30 Novel method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril.

Country Status (36)

Country Link
US (1) US6818788B2 (no)
EP (1) EP1268398B1 (no)
JP (1) JP3930322B2 (no)
KR (1) KR100498869B1 (no)
CN (1) CN1171855C (no)
AP (1) AP1483A (no)
AR (1) AR027754A1 (no)
AT (1) ATE297377T1 (no)
AU (2) AU4843301A (no)
BG (1) BG65832B1 (no)
BR (1) BRPI0109609B1 (no)
CA (1) CA2404700C (no)
CZ (1) CZ302840B6 (no)
DE (1) DE60111364T2 (no)
DK (1) DK1268398T3 (no)
EA (1) EA004314B1 (no)
EE (1) EE05079B1 (no)
ES (1) ES2242743T3 (no)
FR (1) FR2807037B1 (no)
GE (1) GEP20063796B (no)
HK (1) HK1053301A1 (no)
HR (1) HRP20020860B1 (no)
HU (1) HU229188B1 (no)
ME (1) ME00437B (no)
MX (1) MXPA02009378A (no)
NO (1) NO328064B1 (no)
NZ (1) NZ521324A (no)
OA (1) OA12324A (no)
PL (1) PL199714B1 (no)
PT (1) PT1268398E (no)
RS (1) RS50239B (no)
SI (1) SI1268398T1 (no)
SK (1) SK286851B6 (no)
UA (1) UA73562C2 (no)
WO (1) WO2001056353A2 (no)
ZA (1) ZA200207150B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
ATE395913T1 (de) 2003-02-28 2008-06-15 Servier S A Lab Verfahren zur herstellung von perindopril
DK1362845T3 (da) * 2003-09-01 2010-01-18 Servier Lab Ny fremgangsmåde til fremstilling af estere af N-((S)-1-carboxybutyl)-(S)-alanin og deres anvendelse ved fremstilling af perindopril
EP1403278B1 (fr) * 2003-09-30 2005-06-08 Les Laboratoires Servier Procédé de synthèse de la N-((S)-1-carbéthoxybutyl)-(S)-alanine et application à la synthèse du perindopril
ES2256693T3 (es) * 2003-09-30 2006-07-16 Les Laboratoires Servier Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
EA011712B1 (ru) * 2004-03-29 2009-04-28 Ле Лаборатуар Сервье Способ производства твёрдой фармацевтической композиции
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
WO2006006183A2 (en) * 2004-07-12 2006-01-19 Matrix Laboratories Ltd An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247716A (en) * 1977-09-02 1981-01-27 Mitsui Toatsu Chemicals, Inc. Process for producing pyruvic acid
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
RS50239B (sr) 2009-07-15
US20030045744A1 (en) 2003-03-06
FR2807037A1 (fr) 2001-10-05
BG107234A (bg) 2003-07-31
BG65832B1 (bg) 2010-02-26
NO328064B1 (no) 2009-11-16
HU229188B1 (hu) 2013-09-30
DE60111364D1 (de) 2005-07-14
NO20024616L (no) 2002-09-26
WO2001056353A3 (fr) 2002-04-18
CA2404700C (fr) 2007-02-20
FR2807037B1 (fr) 2002-05-10
PT1268398E (pt) 2005-09-30
JP2003534241A (ja) 2003-11-18
HU0101335D0 (en) 2001-06-28
CN1171855C (zh) 2004-10-20
DK1268398T3 (da) 2005-10-03
SK14052002A3 (sk) 2003-02-04
AU4843301A (en) 2001-08-14
HRP20020860A2 (en) 2004-02-29
AU2001248433B2 (en) 2004-10-28
JP3930322B2 (ja) 2007-06-13
HK1053301A1 (en) 2003-10-17
NZ521324A (en) 2004-03-26
AP1483A (en) 2005-10-31
GEP20063796B (en) 2006-04-25
AR027754A1 (es) 2003-04-09
UA73562C2 (uk) 2005-08-15
HRP20020860B1 (en) 2011-02-28
MXPA02009378A (es) 2003-02-12
PL199714B1 (pl) 2008-10-31
ME00437B (me) 2011-10-10
EP1268398B1 (fr) 2005-06-08
HUP0101335A3 (en) 2002-11-28
DE60111364T2 (de) 2006-03-16
KR100498869B1 (ko) 2005-07-04
EP1268398A2 (fr) 2003-01-02
SK286851B6 (sk) 2009-06-05
WO2001056353A2 (fr) 2001-08-09
EA004314B1 (ru) 2004-02-26
BR0109609A (pt) 2004-01-13
EA200201027A1 (ru) 2003-02-27
NO20024616D0 (no) 2002-09-26
CZ302840B6 (cs) 2011-12-07
EE200200553A (et) 2004-04-15
AP2002002628A0 (en) 2002-09-30
BRPI0109609B1 (pt) 2015-04-14
HUP0101335A2 (hu) 2001-11-28
ES2242743T3 (es) 2005-11-16
CN1420862A (zh) 2003-05-28
YU73202A (sh) 2006-03-03
ZA200207150B (en) 2003-09-05
KR20030017484A (ko) 2003-03-03
SI1268398T1 (en) 2005-10-31
EE05079B1 (et) 2008-10-15
US6818788B2 (en) 2004-11-16
PL346554A1 (en) 2001-09-10
CA2404700A1 (fr) 2001-08-09
ATE297377T1 (de) 2005-06-15

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OA12324A (en) Novel method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril.
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