OA12323A - Protease inhibitors. - Google Patents
Protease inhibitors. Download PDFInfo
- Publication number
- OA12323A OA12323A OA1200200295A OA1200200295A OA12323A OA 12323 A OA12323 A OA 12323A OA 1200200295 A OA1200200295 A OA 1200200295A OA 1200200295 A OA1200200295 A OA 1200200295A OA 12323 A OA12323 A OA 12323A
- Authority
- OA
- OAPI
- Prior art keywords
- methyl
- azepan
- pyridine
- amide
- butyl
- Prior art date
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- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract description 9
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- 238000000034 method Methods 0.000 claims abstract description 85
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
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Classifications
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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- C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
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- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
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- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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CA (1) | CA2404206A1 (bg) |
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HU (1) | HUP0300068A2 (bg) |
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SK (1) | SK13632002A3 (bg) |
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WO2001034157A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
AU1474601A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
CN1416346A (zh) | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
US20030114437A1 (en) | 2002-10-17 | 2003-06-19 | Cummings Maxwell D. | Protease inhibitors |
WO2002017924A1 (en) | 2000-09-01 | 2002-03-07 | Smithkline Beecham Corporation | Method of treatment |
CN1635903A (zh) | 2000-11-22 | 2005-07-06 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
US20040034013A1 (en) * | 2001-04-17 | 2004-02-19 | Cummings Maxwell D | Methods of treatment |
WO2002092563A2 (en) | 2001-05-17 | 2002-11-21 | Smithkline Beecham Corporation | Protease inhibitors |
WO2003026770A1 (en) | 2001-09-24 | 2003-04-03 | Smithkline Beecham Corporation | Method for removing metal from the products of olefin metathesis reactions |
WO2003045909A2 (en) | 2001-11-21 | 2003-06-05 | Smithkline Beecham Corporation | Methods and intermediates for the synthesis of azepines |
AU2003265240A1 (en) | 2002-05-22 | 2003-12-22 | Smithkline Beecham Corporation | Protease inhibitors |
EP1532115A4 (en) | 2002-05-22 | 2006-01-11 | Smithkline Beecham Corp | INHIBITORS OF PROTEASE |
US20050256105A1 (en) | 2002-05-22 | 2005-11-17 | Jeong Jae U | Protease inhibitors |
AU2003263738A1 (en) | 2002-05-22 | 2003-12-02 | Smithkline Beecham Corporation | Protease inhibitors |
US7366462B2 (en) | 2003-10-24 | 2008-04-29 | Qualcomm Incorporated | Method and apparatus for seamlessly switching reception between multimedia streams in a wireless communication system |
-
2001
- 2001-03-07 CN CN01806446A patent/CN1416346A/zh active Pending
- 2001-03-07 AU AU2001243441A patent/AU2001243441B2/en not_active Ceased
- 2001-03-07 AU AU4344101A patent/AU4344101A/xx active Pending
- 2001-03-07 PL PL01357727A patent/PL357727A1/xx not_active Application Discontinuation
- 2001-03-07 SK SK1363-2002A patent/SK13632002A3/sk unknown
- 2001-03-07 HU HU0300068A patent/HUP0300068A2/hu unknown
- 2001-03-07 BR BR0109356-8A patent/BR0109356A/pt not_active IP Right Cessation
- 2001-03-07 KR KR1020027012366A patent/KR20020082896A/ko active IP Right Grant
- 2001-03-07 CZ CZ20023168A patent/CZ20023168A3/cs unknown
- 2001-03-07 JP JP2001568430A patent/JP2003527429A/ja active Pending
- 2001-03-07 AP APAP/P/2002/002593A patent/AP1540A/en active
- 2001-03-07 US US10/239,343 patent/US7071184B2/en not_active Expired - Fee Related
- 2001-03-07 EA EA200201001A patent/EA005893B1/ru unknown
- 2001-03-07 MX MXPA02009305A patent/MXPA02009305A/es active IP Right Grant
- 2001-03-07 OA OA1200200295A patent/OA12323A/en unknown
- 2001-03-07 NZ NZ520588A patent/NZ520588A/en unknown
- 2001-03-07 CA CA002404206A patent/CA2404206A1/en not_active Abandoned
- 2001-03-07 DZ DZ013318A patent/DZ3318A1/fr active
- 2001-03-07 EP EP01916412A patent/EP1307203A4/en not_active Withdrawn
- 2001-03-07 IL IL15096401A patent/IL150964A0/xx unknown
- 2001-03-07 WO PCT/US2001/007094 patent/WO2001070232A1/en active IP Right Grant
- 2001-03-19 UY UY26625A patent/UY26625A1/es not_active Application Discontinuation
- 2001-03-21 AR ARP010101323A patent/AR032877A1/es not_active Application Discontinuation
- 2001-03-21 MY MYPI20011339A patent/MY141596A/en unknown
- 2001-03-21 PE PE2001000259A patent/PE20011233A1/es not_active Application Discontinuation
-
2002
- 2002-07-29 BG BG106962A patent/BG106962A/bg unknown
- 2002-09-20 NO NO20024528A patent/NO20024528L/no not_active Application Discontinuation
-
2006
- 2006-04-25 US US11/410,558 patent/US7563784B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU4344101A (en) | 2001-10-03 |
UY26625A1 (es) | 2001-09-28 |
NZ520588A (en) | 2004-06-25 |
WO2001070232A1 (en) | 2001-09-27 |
US7071184B2 (en) | 2006-07-04 |
MXPA02009305A (es) | 2003-03-12 |
AP1540A (en) | 2006-01-11 |
CN1416346A (zh) | 2003-05-07 |
AR032877A1 (es) | 2003-12-03 |
JP2003527429A (ja) | 2003-09-16 |
US7563784B2 (en) | 2009-07-21 |
EA200201001A1 (ru) | 2003-02-27 |
NO20024528D0 (no) | 2002-09-20 |
BG106962A (bg) | 2003-03-31 |
SK13632002A3 (sk) | 2003-02-04 |
US20040044201A1 (en) | 2004-03-04 |
US20060194787A1 (en) | 2006-08-31 |
IL150964A0 (en) | 2003-02-12 |
MY141596A (en) | 2010-05-31 |
PL357727A1 (en) | 2004-07-26 |
EP1307203A4 (en) | 2005-08-17 |
BR0109356A (pt) | 2003-06-03 |
DZ3318A1 (fr) | 2001-09-27 |
EP1307203A1 (en) | 2003-05-07 |
CA2404206A1 (en) | 2001-09-27 |
KR20020082896A (ko) | 2002-10-31 |
EA005893B1 (ru) | 2005-06-30 |
NO20024528L (no) | 2002-11-19 |
HUP0300068A2 (en) | 2003-05-28 |
AP2002002593A0 (en) | 2002-09-30 |
PE20011233A1 (es) | 2002-02-07 |
AU2001243441B2 (en) | 2004-11-25 |
CZ20023168A3 (cs) | 2003-02-12 |
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