OA11354A - Indazole bioisostere replacement of catechol in therapeutically active compounds. - Google Patents

Indazole bioisostere replacement of catechol in therapeutically active compounds. Download PDF

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Publication number
OA11354A
OA11354A OA1200000127A OA1200000127A OA11354A OA 11354 A OA11354 A OA 11354A OA 1200000127 A OA1200000127 A OA 1200000127A OA 1200000127 A OA1200000127 A OA 1200000127A OA 11354 A OA11354 A OA 11354A
Authority
OA
OAPI
Prior art keywords
group
alkyl
consisting essentially
independently selected
hydrogen
Prior art date
Application number
OA1200000127A
Other languages
English (en)
Inventor
Anthony Marfat
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA11354A publication Critical patent/OA11354A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
OA1200000127A 1997-11-04 2000-04-28 Indazole bioisostere replacement of catechol in therapeutically active compounds. OA11354A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6419897P 1997-11-04 1997-11-04
US6422897P 1997-11-04 1997-11-04
US6402497P 1997-11-04 1997-11-04
US6418797P 1997-11-04 1997-11-04
US6422997P 1997-11-04 1997-11-04

Publications (1)

Publication Number Publication Date
OA11354A true OA11354A (en) 2003-12-23

Family

ID=27535645

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000127A OA11354A (en) 1997-11-04 2000-04-28 Indazole bioisostere replacement of catechol in therapeutically active compounds.

Country Status (29)

Country Link
US (1) US6391872B1 (xx)
EP (1) EP1028946A1 (xx)
JP (1) JP2001521926A (xx)
CN (1) CN1284948A (xx)
AP (1) AP910A (xx)
AR (1) AR013746A1 (xx)
AU (1) AU754734B2 (xx)
BG (1) BG104450A (xx)
BR (1) BR9813926A (xx)
CA (1) CA2309150A1 (xx)
CZ (1) CZ20001621A3 (xx)
DZ (1) DZ2640A1 (xx)
EA (1) EA200000488A1 (xx)
HR (1) HRP20000253A2 (xx)
HU (1) HUP0004150A3 (xx)
ID (1) ID23921A (xx)
IL (1) IL135900A0 (xx)
IS (1) IS5465A (xx)
MA (1) MA26563A1 (xx)
NO (1) NO20002129L (xx)
NZ (1) NZ503918A (xx)
OA (1) OA11354A (xx)
PE (1) PE129199A1 (xx)
PL (1) PL340753A1 (xx)
SK (1) SK6252000A3 (xx)
TN (1) TNSN98200A1 (xx)
TR (1) TR200001234T2 (xx)
WO (1) WO1999023077A1 (xx)
YU (1) YU25000A (xx)

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PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US7141581B2 (en) 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
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AU783116B2 (en) * 1999-08-12 2005-09-29 Wyeth Holdings Corporation NSAID and EFGR kinase inhibitor containing composition for the treatment or inhibition of colonic polyps and colorectal cancer
US6432979B1 (en) 1999-08-12 2002-08-13 American Cyanamid Company Method of treating or inhibiting colonic polyps and colorectal cancer
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
WO2001079198A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinase
JP4535680B2 (ja) * 2001-04-16 2010-09-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規１ｈ−インダゾール化合物
CN100496607C (zh) 2001-09-19 2009-06-10 尼科梅德有限责任公司 Nsaid与pde-4抑制剂的并用药物
WO2003024456A1 (en) * 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating and preventing migraines
JP2005518097A (ja) * 2002-02-13 2005-06-16 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 集積半導体光学装置並びにこのような装置を製造する方法及び装置
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
WO2003092599A2 (en) 2002-04-30 2003-11-13 Unigen Pharmaceuticals, Inc. Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
CA2507074A1 (en) 2002-12-02 2004-06-17 F. Hoffmann-La Roche Ag Indazole derivatives as crf antagonists
MXPA05008438A (es) * 2003-02-14 2005-10-19 Wyeth Corp Heterociclil-3-sulfonilindazoles como ligandos de 5-hidroxitriptamina-6.
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
CA2521429A1 (en) * 2003-04-04 2004-10-21 Unigen Pharmaceuticals, Inc. Formulation of dual cycloxygenase (cox) and lipoxygenase (lox) inhibitors for mammal skin care
US6984652B2 (en) * 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
US7844309B2 (en) * 2004-02-27 2010-11-30 Nokia Corporation Exchangeable keymat
CA2557575A1 (en) 2004-02-27 2005-09-15 F. Hoffmann-La Roche Ag Fused derivatives of pyrazole
KR20060114022A (ko) 2004-02-27 2006-11-03 에프. 호프만-라 로슈 아게 인다졸 유도체 및 그들을 함유하는 약학 조성물
MXPA06009462A (es) 2004-02-27 2007-03-15 Hoffmann La Roche Derivados pirazolo heteroaril fusionados.
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
BRPI0518693A2 (pt) * 2004-11-29 2008-12-02 Warner Lambert Co pirazol [3,4-b]piridinas e indazàis terapÊuticos, bem como composiÇço farmacÊutica e uso dos mesmos
BRPI0614343A2 (pt) * 2005-08-15 2011-03-22 Wyeth Corp derivados de 3-sulfonilindazol substituìdo como ligantes de 5-hidroxitriptamina-6
RU2008103700A (ru) * 2005-08-15 2009-09-27 Вайет (Us) Производные азинил-3-сульфонилиндазола в качестве лиганд 5ов 5-гидрокситриптамина-6
BRPI0615442A2 (pt) 2005-08-25 2011-05-17 Hoffmann La Roche inibidores de p38 map cinase e métodos para uso dos mesmos
US7781460B2 (en) 2005-09-05 2010-08-24 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-IV
EP1934219A1 (en) 2005-09-16 2008-06-25 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
EP1960353B1 (en) * 2005-11-03 2014-03-12 Allergan, Inc. Prostaglandins and analogues as agents for lowering intraocular pressure
KR20080114688A (ko) 2006-01-13 2008-12-31 와이어쓰 5-히드록시트립타민 수용체에 대한 리간드로서의 술포닐 치환된 1ｈ-인돌
DK1981851T3 (da) 2006-01-31 2012-03-19 Array Biopharma Inc Kinaseinhibitorer og fremgangsmåder til anvendelse deraf
CA2644069A1 (en) 2006-02-28 2007-09-07 Helicon Therapeutics, Inc. Therapeutic piperazines as pde4 inhibitors
WO2007120523A2 (en) * 2006-03-31 2007-10-25 Vitae Pharmaceuticals, Inc. 6-(aminoalkyl)indazoles
CN101432274A (zh) * 2006-04-05 2009-05-13 惠氏公司 作为5-羟色胺-6配体的磺酰基-3-杂环吲唑衍生物
WO2007120596A1 (en) * 2006-04-12 2007-10-25 Wyeth DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
US8012886B2 (en) * 2007-03-07 2011-09-06 Asm Assembly Materials Ltd Leadframe treatment for enhancing adhesion of encapsulant thereto
AU2008224541B2 (en) 2007-03-14 2013-08-22 Sun Pharmaceutical Industries Limited Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
US8558016B2 (en) * 2009-09-18 2013-10-15 Kabaushiki Kaisha Riverson Polyphenol derivative and method for producing the same
JP2013526542A (ja) 2010-05-12 2013-06-24 アッヴィ・インコーポレイテッド キナーゼのインダゾール阻害薬
CN103709146B (zh) * 2014-01-15 2015-11-25 中国药科大学 一类含苯并咪唑结构的喹啉-4-胺衍生物、其制法及医药用途
KR20230152654A (ko) 2020-12-30 2023-11-03 타이라 바이오사이언시스, 인크. 키나아제 억제제로서의 인다졸 화합물

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EP0338087A4 (en) * 1987-10-13 1991-07-24 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds, process for their preparation, and their medicinal use
US5006520A (en) * 1987-10-13 1991-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds and pharmaceutical use thereof
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
AP2001002304A0 (en) * 1996-05-03 2001-12-31 Pfizer Substituted indazole derivatives and related compounds
CA2264798A1 (en) * 1996-09-04 1998-03-12 Pfizer Inc. Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)

Also Published As

Publication number Publication date
AU9455298A (en) 1999-05-24
EP1028946A1 (en) 2000-08-23
NZ503918A (en) 2002-03-28
WO1999023077A1 (en) 1999-05-14
ID23921A (id) 2000-05-25
US6391872B1 (en) 2002-05-21
AP910A (en) 2000-12-05
AR013746A1 (es) 2001-01-10
BR9813926A (pt) 2000-09-19
CA2309150A1 (en) 1999-05-14
TNSN98200A1 (fr) 2005-03-15
NO20002129D0 (no) 2000-04-26
NO20002129L (no) 2000-07-03
HRP20000253A2 (en) 2001-06-30
PL340753A1 (en) 2001-02-26
IL135900A0 (en) 2001-05-20
AU754734B2 (en) 2002-11-21
SK6252000A3 (en) 2001-11-06
CZ20001621A3 (cs) 2001-08-15
TR200001234T2 (tr) 2000-08-21
MA26563A1 (fr) 2004-12-20
HUP0004150A3 (en) 2001-08-28
DZ2640A1 (fr) 2003-03-08
JP2001521926A (ja) 2001-11-13
EA200000488A1 (ru) 2000-10-30
BG104450A (en) 2000-12-29
AP9801375A0 (en) 1998-12-31
YU25000A (sh) 2003-12-31
HUP0004150A2 (hu) 2001-05-28
IS5465A (is) 2000-04-19
PE129199A1 (es) 1999-12-16
CN1284948A (zh) 2001-02-21

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