OA11154A - Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid - Google Patents

Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid Download PDF

Info

Publication number
OA11154A
OA11154A OA9900201A OA9900201A OA11154A OA 11154 A OA11154 A OA 11154A OA 9900201 A OA9900201 A OA 9900201A OA 9900201 A OA9900201 A OA 9900201A OA 11154 A OA11154 A OA 11154A
Authority
OA
OAPI
Prior art keywords
crystalline hydrated
compound
hydrated form
application
sodium
Prior art date
Application number
OA9900201A
Other languages
English (en)
French (fr)
Inventor
Zadeo Cimarosti
Paolo Maragni
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Publication of OA11154A publication Critical patent/OA11154A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
OA9900201A 1997-03-05 1999-09-02 Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid OA11154A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9704498.6A GB9704498D0 (en) 1997-03-05 1997-03-05 Chemical compound

Publications (1)

Publication Number Publication Date
OA11154A true OA11154A (en) 2003-04-16

Family

ID=10808697

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9900201A OA11154A (en) 1997-03-05 1999-09-02 Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid

Country Status (29)

Country Link
EP (1) EP0966463A1 (id)
JP (1) JP2001513796A (id)
KR (1) KR20000075907A (id)
CN (1) CN1249750A (id)
AP (1) AP9901637A0 (id)
AR (1) AR011178A1 (id)
AU (1) AU6825198A (id)
BG (1) BG103779A (id)
BR (1) BR9808305A (id)
CA (1) CA2282851A1 (id)
CO (1) CO4940415A1 (id)
EA (1) EA199900710A1 (id)
EE (1) EE9900387A (id)
GB (1) GB9704498D0 (id)
HR (1) HRP980114A2 (id)
HU (1) HUP0002109A2 (id)
ID (1) ID24207A (id)
IL (1) IL131489A0 (id)
IS (1) IS5166A (id)
NO (1) NO994303L (id)
NZ (1) NZ337315A (id)
OA (1) OA11154A (id)
PE (1) PE51399A1 (id)
PL (1) PL335652A1 (id)
SK (1) SK119699A3 (id)
TR (1) TR199902117T2 (id)
WO (1) WO1998039327A1 (id)
YU (1) YU43499A (id)
ZA (1) ZA981791B (id)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9704499D0 (en) * 1997-03-05 1997-04-23 Glaxo Wellcome Spa Method of manufacture
GB9825988D0 (en) * 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
WO2018229744A1 (en) 2017-06-12 2018-12-20 Glytech Llc. Treatment of depression with nmda antagonists and d2/5ht2a or selective 5ht2a antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds

Also Published As

Publication number Publication date
AU6825198A (en) 1998-09-22
CA2282851A1 (en) 1998-09-11
ZA981791B (en) 1999-09-03
EA199900710A1 (ru) 2000-04-24
BG103779A (en) 2000-06-30
ID24207A (id) 2000-07-13
HRP980114A2 (en) 1998-12-31
GB9704498D0 (en) 1997-04-23
EP0966463A1 (en) 1999-12-29
CO4940415A1 (es) 2000-07-24
BR9808305A (pt) 2000-05-16
PL335652A1 (en) 2000-05-08
AP9901637A0 (en) 1999-09-30
TR199902117T2 (xx) 2000-03-21
JP2001513796A (ja) 2001-09-04
HUP0002109A2 (hu) 2001-04-28
NO994303L (no) 1999-11-03
PE51399A1 (es) 1999-06-07
KR20000075907A (ko) 2000-12-26
NZ337315A (en) 2001-02-23
IL131489A0 (en) 2001-01-28
EE9900387A (et) 2000-04-17
CN1249750A (zh) 2000-04-05
SK119699A3 (en) 2000-05-16
WO1998039327A1 (en) 1998-09-11
IS5166A (is) 1999-08-27
AR011178A1 (es) 2000-08-02
YU43499A (sh) 2000-12-28
NO994303D0 (no) 1999-09-03

Similar Documents

Publication Publication Date Title
AP480A (en) 3-Substituted indole 2-carboxylic acid derivatives.
JP3908248B2 (ja) Hivインテグラーゼ阻害活性を有するヘテロ環化合物
TW201533042A (zh) αvβ整合素拮抗劑
JP2010132688A (ja) 1−4−(5−シアノインドール−3−イル)ブチル−4−(2−カルバモイルベンゾフラン−5−イル)ピペラジン塩酸塩の多形相
CN104987321A (zh) 制造嘧啶衍生物的方法
WO2013004190A1 (zh) 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途
JPH09503770A (ja) Nmdaアンタゴニストとしてのインドール誘導体
KR20240027877A (ko) 2,4,6-트리플루오로-n-[6-(1-메틸-피페리딘-4-카르보닐)-피리딘-2-일]-벤즈아미드헤미숙시네이트의 대규모 제조를 위한 방법 및 중간체, 및 2,4,6-트리플루오로-n-[6-(1-메틸-피페리딘-4-카르보닐)-피리딘-2-일]-벤즈아미드 아세테이트의 제조
OA11154A (en) Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid
TW201713661A (zh) 化合物
JP2001518901A (ja) キノリン−2−カルボン酸誘導体およびその興奮性アミノ酸拮抗薬としての使用
CA2393303C (en) Meglumine salt of a specific quinolinecarboxylic acid compound
CN113788835B (zh) 一种含吗啉和喹啉环的三唑并四嗪类化合物及其制备方法和应用
WO2013030374A1 (en) Novel crystal form
US20240092780A1 (en) Adducts and dimer compounds synthesized using gk method
CZ314799A3 (cs) Krystalická hydratovaná sodná sůl kyseliny (E)-4,6-dichlor-3-(2-oxo-l-fenylpyrrolidin-3- ylidenmethyl)-lH-indol-2-karboxylové
TW202136243A (zh) Zeste增強子同源物2抑制劑及其用途
EP2373628A1 (en) Novel compounds
KR20030069228A (ko) 나트륨-수소 교환물질 1형 억제제의 에탄올레이트