CN1249750A - (e)-4,6-二氯-3-(2-氧代-1-苯基吡咯烷-3-亚基甲基)-1h-吲哚-2-甲酸的结晶水合钠盐) - Google Patents

(e)-4,6-二氯-3-(2-氧代-1-苯基吡咯烷-3-亚基甲基)-1h-吲哚-2-甲酸的结晶水合钠盐) Download PDF

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Publication number
CN1249750A
CN1249750A CN98803053A CN98803053A CN1249750A CN 1249750 A CN1249750 A CN 1249750A CN 98803053 A CN98803053 A CN 98803053A CN 98803053 A CN98803053 A CN 98803053A CN 1249750 A CN1249750 A CN 1249750A
Authority
CN
China
Prior art keywords
sodium salt
crystalline hydrate
compound
hydrate form
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98803053A
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English (en)
Chinese (zh)
Inventor
Z·奇马洛斯蒂
P·马拉格尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Glaxo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo SpA filed Critical Glaxo SpA
Publication of CN1249750A publication Critical patent/CN1249750A/zh
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CN98803053A 1997-03-05 1998-03-03 (e)-4,6-二氯-3-(2-氧代-1-苯基吡咯烷-3-亚基甲基)-1h-吲哚-2-甲酸的结晶水合钠盐) Pending CN1249750A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9704498.6 1997-03-05
GBGB9704498.6A GB9704498D0 (en) 1997-03-05 1997-03-05 Chemical compound

Publications (1)

Publication Number Publication Date
CN1249750A true CN1249750A (zh) 2000-04-05

Family

ID=10808697

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98803053A Pending CN1249750A (zh) 1997-03-05 1998-03-03 (e)-4,6-二氯-3-(2-氧代-1-苯基吡咯烷-3-亚基甲基)-1h-吲哚-2-甲酸的结晶水合钠盐)

Country Status (29)

Country Link
EP (1) EP0966463A1 (id)
JP (1) JP2001513796A (id)
KR (1) KR20000075907A (id)
CN (1) CN1249750A (id)
AP (1) AP9901637A0 (id)
AR (1) AR011178A1 (id)
AU (1) AU6825198A (id)
BG (1) BG103779A (id)
BR (1) BR9808305A (id)
CA (1) CA2282851A1 (id)
CO (1) CO4940415A1 (id)
EA (1) EA199900710A1 (id)
EE (1) EE9900387A (id)
GB (1) GB9704498D0 (id)
HR (1) HRP980114A2 (id)
HU (1) HUP0002109A2 (id)
ID (1) ID24207A (id)
IL (1) IL131489A0 (id)
IS (1) IS5166A (id)
NO (1) NO994303L (id)
NZ (1) NZ337315A (id)
OA (1) OA11154A (id)
PE (1) PE51399A1 (id)
PL (1) PL335652A1 (id)
SK (1) SK119699A3 (id)
TR (1) TR199902117T2 (id)
WO (1) WO1998039327A1 (id)
YU (1) YU43499A (id)
ZA (1) ZA981791B (id)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9704499D0 (en) * 1997-03-05 1997-04-23 Glaxo Wellcome Spa Method of manufacture
GB9825988D0 (en) * 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
WO2018229744A1 (en) 2017-06-12 2018-12-20 Glytech Llc. Treatment of depression with nmda antagonists and d2/5ht2a or selective 5ht2a antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds

Also Published As

Publication number Publication date
AU6825198A (en) 1998-09-22
CA2282851A1 (en) 1998-09-11
ZA981791B (en) 1999-09-03
EA199900710A1 (ru) 2000-04-24
BG103779A (en) 2000-06-30
ID24207A (id) 2000-07-13
HRP980114A2 (en) 1998-12-31
GB9704498D0 (en) 1997-04-23
EP0966463A1 (en) 1999-12-29
CO4940415A1 (es) 2000-07-24
BR9808305A (pt) 2000-05-16
PL335652A1 (en) 2000-05-08
AP9901637A0 (en) 1999-09-30
TR199902117T2 (xx) 2000-03-21
OA11154A (en) 2003-04-16
JP2001513796A (ja) 2001-09-04
HUP0002109A2 (hu) 2001-04-28
NO994303L (no) 1999-11-03
PE51399A1 (es) 1999-06-07
KR20000075907A (ko) 2000-12-26
NZ337315A (en) 2001-02-23
IL131489A0 (en) 2001-01-28
EE9900387A (et) 2000-04-17
SK119699A3 (en) 2000-05-16
WO1998039327A1 (en) 1998-09-11
IS5166A (is) 1999-08-27
AR011178A1 (es) 2000-08-02
YU43499A (sh) 2000-12-28
NO994303D0 (no) 1999-09-03

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