OA10804A - Substituted N-[(aminoiminomethyl or aminomethyl) phenyl]propyl amides - Google Patents

Substituted N-[(aminoiminomethyl or aminomethyl) phenyl]propyl amides Download PDF

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OA10804A
OA10804A OA9800100A OA9800100A OA10804A OA 10804 A OA10804 A OA 10804A OA 9800100 A OA9800100 A OA 9800100A OA 9800100 A OA9800100 A OA 9800100A OA 10804 A OA10804 A OA 10804A
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OAPI
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compound
nmr
mmol
optionally substituted
solution
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OA9800100A
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English (en)
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Kevin R Guertin
Scott I Klein
Alfred P Spada
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Rhone Poulenc Rorer Pharma
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Publication of OA10804A publication Critical patent/OA10804A/en

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
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    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/04—Ortho-condensed systems

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OA9800100A 1996-01-02 1998-07-01 Substituted N-[(aminoiminomethyl or aminomethyl) phenyl]propyl amides OA10804A (en)

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US6080767A (en) * 1996-01-02 2000-06-27 Aventis Pharmaceuticals Products Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
TW542822B (en) * 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
US6620961B1 (en) * 1997-08-26 2003-09-16 Kumiai Chemical Industry Co., Ltd. Biarylalkylenecarbamic acid derivatives and bacteriocides for agricultural and horticultural use
US6740682B2 (en) 1997-08-29 2004-05-25 Tularik Limited Meta-benzamidine derivatives as serine protease inhibitors
AU757868B2 (en) * 1998-03-23 2003-03-06 Aventis Pharmaceuticals Inc. Piperididinyl and N-amidinopiperidinyl derivatives
KR20010052694A (ko) * 1998-06-08 2001-06-25 에가시라 구니오 벤즈아미딘 유도체
AU3127900A (en) 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
DE69931393T2 (de) 1998-12-23 2007-03-29 Eli Lilly And Co., Indianapolis Antithrombotische amide
KR20010086461A (ko) * 1998-12-24 2001-09-12 오흘러 로스 제이. 인자 ｘａ 억제제로서의 치환된 (아미노이미노메틸 또는아미노메틸)벤조헤테로아릴 화합물
EP1022268A1 (en) * 1999-01-02 2000-07-26 Aventis Pharma Deutschland GmbH Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
WO2000040548A1 (en) * 1999-01-02 2000-07-13 Aventis Pharma Deutschland Gmbh Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
US6794412B1 (en) * 1999-03-11 2004-09-21 Bristol-Myers Squibb Pharma Company Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin
ES2248084T3 (es) 1999-06-14 2006-03-16 Eli Lilly And Company Inhibidores de serinproteasa.
EP1245564B1 (en) * 1999-10-28 2006-04-05 Sankyo Company, Limited Benzamidine derivatives
DE60011128T2 (de) 1999-11-02 2005-07-07 Aventis Pharma Deutschland Gmbh Monitoring der aktivität von faktor xa-inhibitoren
DE10006601A1 (de) 2000-02-15 2001-08-16 Clariant Gmbh Verfahren zur Herstellung von 4-(4'-Carboxyphenyl)pyridin
GB0108903D0 (en) * 2000-10-05 2001-05-30 Aventis Pharm Prod Inc Novel crystalline forms of a factor Xa inhibitor
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
DE102006048300A1 (de) 2006-01-26 2007-08-02 Hellstern, Peter, Prof. Dr.med. Inhibitoren des Blutgerinnungsfaktors Xa zur Verwendung als Antikoagulans
AU2010237271B2 (en) * 2009-04-17 2015-08-20 Merz Pharma Gmbh & Co. Kgaa Synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate
CA2766533A1 (en) 2009-07-29 2011-02-03 Sanofi Otamixaban for treatment of elderly and renal impaired non-st elevation myocardial infarction patients
GB0919194D0 (en) 2009-11-02 2009-12-16 Lytix Biopharma As Compounds
PH12013501991A1 (en) 2011-03-29 2013-11-25 Sanofi Sa Otamixaban formulations with improved stability
SG193612A1 (en) * 2011-03-29 2013-11-29 Sanofi Sa Benzoic acid salt of otamixaban
WO2013042782A1 (ja) 2011-09-22 2013-03-28 武田薬品工業株式会社 縮合複素環化合物
AU2013310973A1 (en) 2012-08-31 2015-03-12 Sanofi Otamixaban for use in the treatment of non-ST elevation acute coronary syndrome in patients planned to undergo coronary artery bypass grafting
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
US10351750B2 (en) 2017-02-03 2019-07-16 Saudi Arabian Oil Company Drilling fluid compositions with enhanced rheology and methods of using same
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide

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ATE243512T1 (de) 2003-07-15
RO117913B1 (ro) 2002-09-30
JP4053597B2 (ja) 2008-02-27
UA46821C2 (uk) 2002-06-17
EA001932B1 (ru) 2001-10-22
BR9612423B1 (pt) 2010-11-30
SK89798A3 (en) 2000-08-14
CA2241904C (en) 2004-12-21
BR9612423A (pt) 1999-12-28
CL2004000376A1 (es) 2005-06-03
KR19990076965A (ko) 1999-10-25
AU723338B2 (en) 2000-08-24
CN1208347A (zh) 1999-02-17
AU1520797A (en) 1997-07-28
DE69628856T2 (de) 2004-05-06
HK1017613A1 (en) 1999-11-26
AP9801288A0 (en) 1998-09-30
NO983039L (no) 1998-09-02
EA199800620A1 (ru) 1999-02-25
EA199900669A1 (ru) 2000-06-26
WO1997024118A1 (en) 1997-07-10
PL327633A1 (en) 1998-12-21
NO310719B1 (no) 2001-08-20
PL185460B1 (pl) 2003-05-30
CA2241904A1 (en) 1997-07-10
EP0906094A1 (en) 1999-04-07
ES2197257T3 (es) 2004-01-01
IL125163A0 (en) 1999-01-26
DK0906094T3 (da) 2003-10-20
CZ297544B6 (cs) 2007-02-07
BG102619A (en) 1999-04-30
EA001280B1 (ru) 2000-12-25
US6140504A (en) 2000-10-31
SI0906094T1 (en) 2003-12-31
SI9620136A (sl) 1999-04-30
BG64143B1 (bg) 2004-02-27
DE69628856D1 (de) 2003-07-31
EP0906094A4 (en) 2000-05-17
AP861A (en) 2000-08-01
CZ9802010A3 (cs) 1999-09-15
JP2000502710A (ja) 2000-03-07
CN1273128C (zh) 2006-09-06
HUP9900930A3 (en) 2001-11-28
HU228355B1 (en) 2013-03-28
NO983039D0 (no) 1998-06-30
SI9620136B (en) 2005-08-31
EP0906094B1 (en) 2003-06-25
PT906094E (pt) 2003-11-28
SK284507B6 (sk) 2005-05-05
KR100348338B1 (ko) 2003-06-02
HUP9900930A2 (hu) 1999-08-30

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