OA10190A - Sialyl lex analogues as inhibitors of cellular adhesion - Google Patents
Sialyl lex analogues as inhibitors of cellular adhesion Download PDFInfo
- Publication number
- OA10190A OA10190A OA60733A OA60733A OA10190A OA 10190 A OA10190 A OA 10190A OA 60733 A OA60733 A OA 60733A OA 60733 A OA60733 A OA 60733A OA 10190 A OA10190 A OA 10190A
- Authority
- OA
- OAPI
- Prior art keywords
- group
- compound
- alkyl
- aryl
- hydrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6212093A | 1993-05-14 | 1993-05-14 | |
US24164594A | 1994-05-12 | 1994-05-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
OA10190A true OA10190A (en) | 1996-12-18 |
Family
ID=26741894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA60733A OA10190A (en) | 1993-05-14 | 1995-11-10 | Sialyl lex analogues as inhibitors of cellular adhesion |
Country Status (17)
Country | Link |
---|---|
US (1) | US5604207A (no) |
EP (1) | EP0698031A4 (no) |
JP (1) | JPH08510729A (no) |
CN (1) | CN1125449A (no) |
AU (1) | AU687408B2 (no) |
BG (1) | BG100137A (no) |
CA (1) | CA2162478A1 (no) |
CZ (1) | CZ298895A3 (no) |
FI (1) | FI955467A (no) |
HU (1) | HUT74506A (no) |
NO (1) | NO954571L (no) |
NZ (1) | NZ266972A (no) |
OA (1) | OA10190A (no) |
PL (1) | PL176272B1 (no) |
RO (1) | RO117533B1 (no) |
SK (1) | SK141695A3 (no) |
WO (1) | WO1994026760A1 (no) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811404A (en) * | 1993-05-14 | 1998-09-22 | Cytel Corporation | Sialyl Lex analogues as inhibitors of cellular adhesion |
US5854218A (en) * | 1993-05-14 | 1998-12-29 | Cytel Corporation | Sialyl Lex analogues as inhibitors of cellular adhesion |
FR2716624B1 (fr) * | 1994-02-25 | 1996-05-03 | Jouveinal Lab | Gelée laxative hypocalorique à base d'huile de paraffine liquide et de lactulose, son procédé de préparation. |
WO1996009309A1 (en) * | 1994-09-20 | 1996-03-28 | Pharmacia & Upjohn Company | The oligosaccharide structure of a ligand for e and p selectin |
CA2209084A1 (en) * | 1994-12-28 | 1996-07-04 | Hiroshi Miyauchi | Lewis x derivative and process for producing the same |
US5922577A (en) * | 1995-04-11 | 1999-07-13 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
US6030815A (en) * | 1995-04-11 | 2000-02-29 | Neose Technologies, Inc. | Enzymatic synthesis of oligosaccharides |
US5876980A (en) * | 1995-04-11 | 1999-03-02 | Cytel Corporation | Enzymatic synthesis of oligosaccharides |
US5728554A (en) * | 1995-04-11 | 1998-03-17 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
JPH0940582A (ja) * | 1995-07-28 | 1997-02-10 | Sumitomo Pharmaceut Co Ltd | 神経障害治療剤 |
JPH0952902A (ja) * | 1995-08-09 | 1997-02-25 | Daikin Ind Ltd | フッ素含有シアリルルイスx誘導体及びその合成中間体 |
CZ89098A3 (cs) * | 1995-09-29 | 1998-09-16 | Glycim Oy | Syntetické polylaktosaminy obsahující až multivalentní sLEX a metody pro jejich použití |
WO1997014707A1 (en) * | 1995-10-18 | 1997-04-24 | Cytel Corporation | SIALYL Lex ANALOGUES AS INHIBITORS OF CELLULAR ADHESION |
DE19540388A1 (de) * | 1995-10-30 | 1997-05-07 | Hoechst Ag | Neuartige Glycomimetika als Selektin-Antagonisten und entzündungshemmend wirkende Arzneimittel |
US6169077B1 (en) | 1996-01-30 | 2001-01-02 | Glycotech Corp. | Sialyl-Lewisa and sialyl-Lewisx epitope analogues |
EP0886639B1 (en) * | 1996-01-30 | 2008-05-28 | GlycoMimetics, Inc. | SIALYL-LEWISa AND SIALYL-LEWISx EPITOPE ANALOGUES |
WO1997037682A1 (en) * | 1996-04-10 | 1997-10-16 | Cytel Corporation | Nucleic acids encoding gdp-fucose pyrophosphorylase |
CN1227563A (zh) * | 1996-08-08 | 1999-09-01 | 诺瓦提斯公司 | 改性低聚糖 |
US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
JPH1135593A (ja) * | 1997-07-18 | 1999-02-09 | Daikin Ind Ltd | 2−フルオロフコシル−n−アロイルグルコサミン誘導体及びその中間物、並びにそれらの製造方法 |
US6191271B1 (en) | 1997-09-05 | 2001-02-20 | Glycim Oy | Synthetic divalent sLex containing polylactosamines and methods for use |
WO1999061033A1 (en) * | 1998-05-22 | 1999-12-02 | University Of Houston | Bifunctional molecules for binding and regulating e-selectins and methods detecting same |
WO2001075107A2 (en) * | 2000-03-31 | 2001-10-11 | Genetics Institute, Llc. | Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis |
DE10029915B4 (de) * | 2000-06-19 | 2005-06-16 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungen |
EP1337539A2 (en) * | 2000-11-29 | 2003-08-27 | Bracco International B.V. | Linkable sialyl lewis x analogs |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
CA2486106C (en) * | 2002-05-16 | 2013-07-16 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
CA2490703A1 (en) * | 2002-07-03 | 2004-01-15 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
MXPA05003844A (es) * | 2002-10-11 | 2005-06-22 | Yamanouchi Europ Bv | Compuestos con base de glucosa con afinidad para p-selectina. |
US7645873B2 (en) | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
CA2546784A1 (en) * | 2003-11-19 | 2005-06-16 | Glycomimetics, Inc. | Glycomimetic antagonists for both e- and p-selectins |
EP1763533B1 (en) * | 2003-11-19 | 2008-01-09 | GlycoMimetics, Inc. | Specific antagonist for both e- and p-selectins |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
JP5948627B2 (ja) | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | 線維芽細胞成長因子(fgf)のリモデリングと糖質ペグ化 |
US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
US7130107B2 (en) | 2004-12-07 | 2006-10-31 | Xerox Corporation | Method of preparing encapsulated bichromal balls |
EP1858543B1 (en) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylated granulocyte colony stimulating factor |
DK1848813T3 (da) | 2005-01-28 | 2013-07-15 | Univ Brigham Young | Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler |
EP2386571B1 (en) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
CN101291946B (zh) * | 2005-08-09 | 2011-06-29 | 糖模拟物有限公司 | 对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂 |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
LT2264043T (lt) * | 2005-09-02 | 2017-12-11 | Glycomimetics, Inc. | Heterobifunkciniai pan-selektino inhibitoriai |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
ES2397975T3 (es) | 2006-04-07 | 2013-03-12 | The Scrips Research Institute | Galactosilceramida modificada para el tratamiento de enfermedades cancerosas |
US20090176717A1 (en) * | 2006-06-01 | 2009-07-09 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
JP5564672B2 (ja) * | 2006-06-30 | 2014-07-30 | ザ スクリプス リサーチ インスティテュート | アジュバント及びその使用方法 |
US9187532B2 (en) | 2006-07-21 | 2015-11-17 | Novo Nordisk A/S | Glycosylation of peptides via O-linked glycosylation sequences |
JP2010505874A (ja) | 2006-10-03 | 2010-02-25 | ノヴォ ノルディスク アー/エス | ポリペプチドコンジュゲートの精製方法 |
EP2074132B1 (en) | 2006-10-12 | 2013-05-15 | GlycoMimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
NZ598863A (en) * | 2007-02-09 | 2013-11-29 | Glycomimetics Inc | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
KR20150064246A (ko) | 2007-04-03 | 2015-06-10 | 바이오제너릭스 게엠베하 | 글리코페길화 g―csf를 이용하는 치료 방법 |
CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
US8916164B2 (en) * | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
EP2058011A1 (en) * | 2007-11-07 | 2009-05-13 | Wittycell | Nkt cell activating gycolipids covalently bound antigens and/or drug |
EP2231145B1 (en) * | 2007-12-05 | 2014-09-17 | Wittycell | Use of glycosylceramides for enhancing the immune response to antigens |
WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
ES2426784T3 (es) * | 2008-06-13 | 2013-10-25 | Glycomimetics, Inc. | Tratamiento de cánceres de la sangre usando compuestos glicomiméticos seleccionados |
CA2739765A1 (en) * | 2008-10-08 | 2010-04-15 | Vincent Serra | Vaccine composition for use against influenza |
WO2010126888A1 (en) * | 2009-05-01 | 2010-11-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
CA2858099C (en) | 2011-12-22 | 2020-12-15 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
DK2928476T3 (en) | 2012-12-07 | 2018-05-22 | Glycomimetics Inc | RELATIONSHIPS, COMPOSITIONS AND METHODS OF USING E-SELECTIN ANTAGONISTS FOR MOBILIZATION OF HEMATOPOIETIC CELLS |
DK3227310T3 (da) | 2014-12-03 | 2019-09-30 | Glycomimetics Inc | Heterobifunktionelle inhibitorer af e-selektiner og cxcr4-kemokin-receptorer |
WO2017127422A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
WO2018068010A1 (en) | 2016-10-07 | 2018-04-12 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
CN106632531B (zh) * | 2017-01-03 | 2019-02-22 | 河南科技学院 | 一种α-2,3羟乙酰唾液酸乳果糖的制备方法 |
EP3596096A1 (en) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
AU2018395417B2 (en) | 2017-12-29 | 2023-07-13 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
CA3091454A1 (en) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324663A (en) * | 1990-02-14 | 1994-06-28 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
US5143712A (en) * | 1990-07-30 | 1992-09-01 | Glycomed Incorporated | Method of determining a site of inflammation utilizing elam-1 ligands |
US5211936A (en) * | 1990-07-30 | 1993-05-18 | Glycomed Incorporated | Method of determining a cite of inflammation utilizing elam-1 ligands site |
US5211937A (en) * | 1990-07-30 | 1993-05-18 | Glycomed Incorporated | Method of determining a site of inflammation utilizing elam-1 ligands |
NZ240316A (en) * | 1990-10-25 | 1996-12-20 | Univ Michigan | Compound for treating disease mediated by the elaboration of elam-1 on endothelial cells |
US5352670A (en) * | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
US5559103A (en) * | 1993-07-21 | 1996-09-24 | Cytel Corporation | Bivalent sialyl X saccharides |
-
1994
- 1994-05-13 JP JP6525720A patent/JPH08510729A/ja active Pending
- 1994-05-13 EP EP94917377A patent/EP0698031A4/en not_active Withdrawn
- 1994-05-13 AU AU69120/94A patent/AU687408B2/en not_active Ceased
- 1994-05-13 CZ CZ952988A patent/CZ298895A3/cs unknown
- 1994-05-13 CN CN94192281A patent/CN1125449A/zh active Pending
- 1994-05-13 SK SK1416-95A patent/SK141695A3/sk unknown
- 1994-05-13 NZ NZ266972A patent/NZ266972A/xx unknown
- 1994-05-13 RO RO95-01975A patent/RO117533B1/ro unknown
- 1994-05-13 CA CA002162478A patent/CA2162478A1/en not_active Abandoned
- 1994-05-13 WO PCT/US1994/005336 patent/WO1994026760A1/en not_active Application Discontinuation
- 1994-05-13 PL PL94311667A patent/PL176272B1/pl unknown
- 1994-05-13 HU HU9503268A patent/HUT74506A/hu unknown
- 1994-11-28 US US08/345,072 patent/US5604207A/en not_active Expired - Fee Related
-
1995
- 1995-11-10 OA OA60733A patent/OA10190A/en unknown
- 1995-11-13 NO NO954571A patent/NO954571L/no unknown
- 1995-11-13 FI FI955467A patent/FI955467A/fi unknown
- 1995-11-13 BG BG100137A patent/BG100137A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NO954571D0 (no) | 1995-11-13 |
NZ266972A (en) | 1997-08-22 |
CN1125449A (zh) | 1996-06-26 |
HUT74506A (en) | 1997-01-28 |
HU9503268D0 (en) | 1996-01-29 |
JPH08510729A (ja) | 1996-11-12 |
SK141695A3 (en) | 1996-10-02 |
CA2162478A1 (en) | 1994-11-24 |
EP0698031A4 (en) | 1997-07-09 |
CZ298895A3 (en) | 1996-04-17 |
FI955467A (fi) | 1995-12-19 |
EP0698031A1 (en) | 1996-02-28 |
NO954571L (no) | 1996-01-12 |
RO117533B1 (ro) | 2002-04-30 |
PL311667A1 (en) | 1996-03-04 |
AU687408B2 (en) | 1998-02-26 |
FI955467A0 (fi) | 1995-11-13 |
BG100137A (en) | 1996-11-29 |
WO1994026760A1 (en) | 1994-11-24 |
AU6912094A (en) | 1994-12-12 |
PL176272B1 (pl) | 1999-05-31 |
US5604207A (en) | 1997-02-18 |
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