OA10130A - Beads having a core coated with an antifungal and a polymer - Google Patents

Beads having a core coated with an antifungal and a polymer Download PDF

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Publication number
OA10130A
OA10130A OA60618A OA60618A OA10130A OA 10130 A OA10130 A OA 10130A OA 60618 A OA60618 A OA 60618A OA 60618 A OA60618 A OA 60618A OA 10130 A OA10130 A OA 10130A
Authority
OA
OAPI
Prior art keywords
coating
percent
beads
seal
antifungal agent
Prior art date
Application number
OA60618A
Other languages
English (en)
Inventor
Paul Marie Victor Gilis
De Valentin Florent Victor Conde
Roger Petrus Gerebern Vandecruys
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8210890&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA10130(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of OA10130A publication Critical patent/OA10130A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Materials For Medical Uses (AREA)
OA60618A 1992-09-03 1995-03-01 Beads having a core coated with an antifungal and a polymer OA10130A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92202664 1992-09-03

Publications (1)

Publication Number Publication Date
OA10130A true OA10130A (en) 1996-12-18

Family

ID=8210890

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60618A OA10130A (en) 1992-09-03 1995-03-01 Beads having a core coated with an antifungal and a polymer

Country Status (33)

Country Link
US (1) US5633015A (es)
EP (1) EP0658103B1 (es)
JP (1) JP2865869B2 (es)
KR (1) KR0151893B1 (es)
CN (1) CN1034714C (es)
AP (1) AP444A (es)
AT (1) ATE145327T1 (es)
AU (1) AU665867B2 (es)
CA (1) CA2142848C (es)
CY (1) CY2105B1 (es)
CZ (1) CZ283403B6 (es)
DE (1) DE69306119T2 (es)
DK (1) DK0658103T3 (es)
ES (1) ES2097536T3 (es)
FI (1) FI112437B (es)
GR (1) GR3022198T3 (es)
HK (1) HK1006000A1 (es)
HR (1) HRP931158B1 (es)
HU (1) HU220614B1 (es)
IL (1) IL106871A (es)
MX (1) MX9305438A (es)
MY (1) MY109369A (es)
NO (1) NO307953B1 (es)
NZ (1) NZ255379A (es)
OA (1) OA10130A (es)
PH (1) PH30929A (es)
PL (2) PL172676B1 (es)
RU (1) RU2125445C1 (es)
SG (1) SG48801A1 (es)
SI (1) SI9300461B (es)
TW (1) TW376322B (es)
WO (1) WO1994005263A1 (es)
ZA (1) ZA936493B (es)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9325445D0 (en) 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
US7008668B2 (en) 1995-05-09 2006-03-07 Phoqus Pharmaceuticals Limited Powder coating composition for electrostatic coating of pharmaceutical substrates
TR199701324T1 (xx) 1995-05-09 1998-04-21 Colorcon Limited Elektrostatik kaplama.
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
CA2240161C (en) 1996-05-20 2005-05-24 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
PL330864A1 (en) * 1996-06-28 1999-06-07 Schering Corp Orally administered composition containing antimycotic compounds of triazole
GB9623634D0 (en) 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
IL129575A (en) * 1997-03-26 2004-06-20 Janssen Pharmaceutica Nv Pills with a core coated with a fungicide and polymer
KR19990001564A (ko) 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
AU1511399A (en) * 1997-12-31 1999-07-19 Choongwae Pharma Corporation Method and composition of an oral preparation of itraconazole
KR100514330B1 (ko) * 1997-12-31 2006-02-17 주식회사 중외제약 난용성 약물을 함유하는 코팅정
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
UA65607C2 (uk) * 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
KR100549095B1 (ko) * 1998-07-17 2006-02-06 얀센 파마슈티카 엔.브이. 항진균제 및 중합체로 코팅된 코어를 갖는 펠릿
ES2157731B1 (es) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
ATE307808T1 (de) 1999-03-24 2005-11-15 Scherer Technologies Inc R P Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US20060034937A1 (en) * 1999-11-23 2006-02-16 Mahesh Patel Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
KR100694667B1 (ko) * 1999-12-08 2007-03-14 동아제약주식회사 생체내이용률 향상과 개인간 및 개인내 흡수 편차를감소시킨 이트라코나졸 함유 항진균성 제제
PT1239831E (pt) * 1999-12-23 2013-01-23 Mayne Pharma International Pty Ltd Composições farmacêuticas melhoradas para fármacos fracamente solúveis
CN101385732A (zh) * 2000-02-29 2009-03-18 布里斯托尔-迈尔斯斯奎布公司 低剂量艾替开韦制剂及其应用
US6551608B2 (en) * 2000-03-06 2003-04-22 Porex Technologies Corporation Porous plastic media with antiviral or antimicrobial properties and processes for making the same
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6673373B2 (en) * 2001-02-01 2004-01-06 Carlsbad Technology Inc. Antifungal formulation and the methods for manufacturing and using the same
US6663897B2 (en) 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
HU229224B1 (en) 2001-02-14 2013-09-30 Tibotec Pharmaceuticals Ltd Little Island 2-(substituted-amino)-benzothiazole sulfonamide compounds having broadspectrum hiv protease inhibitor activity and medicaments containing them
OA12464A (en) 2001-04-09 2006-05-24 Tibotec Pharm Ltd Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors.
DK1387842T3 (da) 2001-05-11 2009-08-10 Tibotec Pharm Ltd Bredspektrede 2-amino-benzoxazolsulfonamid-HIV-protease-inhibitorer
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
KR100438485B1 (ko) * 2001-08-13 2004-07-09 한국디디에스제약 주식회사 아졸류 항진균제의 약제학적 조성물
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
CA2363376A1 (en) * 2001-11-16 2003-05-16 Bernard Charles Sherman Solid pharmaceutical compositions for oral administration comprising itraconazole
MY138657A (en) 2001-12-21 2009-07-31 Tibotec Pharm Ltd broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
US7446107B2 (en) * 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7078526B2 (en) * 2002-05-31 2006-07-18 Transform Pharmaceuticals, Inc. CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20030224006A1 (en) 2002-03-01 2003-12-04 Zaworotko Michael J. Multiple-component solid phases containing at least one active pharmaceutical ingredient
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
JP4674084B2 (ja) 2002-05-17 2011-04-20 テイボテク・フアーマシユーチカルズ・リミテツド 広域スペクトルの置換ベンズイソキサゾールスルホンアミドhivプロテアーゼ阻害剤
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
JP2006500377A (ja) * 2002-06-21 2006-01-05 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 改善された溶解性を有する医薬組成物
WO2004009120A1 (en) * 2002-07-22 2004-01-29 Nanohybrid Co., Ltd. Hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate and a process for preparing the same
US7429619B2 (en) * 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
NZ538714A (en) 2002-08-14 2007-03-30 Tibotec Pharm Ltd Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors
US20040086567A1 (en) * 2002-10-30 2004-05-06 Pawan Seth Bioequivalent composition of itraconazole and a hydrophilic polymer
CA2507018C (en) 2002-11-26 2014-03-25 John C. Alverdy Materials and methods for preventing and treating microbe-mediated epithelial disorders
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
PT1438961E (pt) * 2003-01-14 2007-05-31 Cimex Pharma Ag Composição bioquivalente de itraconazol disperso num polímero hidrofílico.
PT1438960E (pt) * 2003-01-14 2007-06-19 Cimex Pharma Ag Composição de itraconazole disperso num polímero hidrofílico possuindo biodisponibilidade melhorada
FR2852607B1 (fr) * 2003-03-20 2006-07-14 Procede de fabrication de microspheres de sucre de petite taille, les microspheres susceptibles d'etre obtenues par ce procede et leurs applications
TW200518742A (en) 2003-09-11 2005-06-16 Tibotec Pharm Ltd Entry inhibitors
US20050074494A1 (en) * 2003-10-06 2005-04-07 Xiu-Xiu Cheng Itraconazole immediate release formulation
US20050118265A1 (en) * 2003-11-28 2005-06-02 Anandi Krishnan Antifungal oral dosage forms and the methods for preparation
US9247765B2 (en) 2004-01-14 2016-02-02 Omniactive Health Technologies Limited Stable beadlets of lipophilic nutrients
WO2005084639A2 (en) * 2004-03-03 2005-09-15 Spherics, Inc. Polymeric drug delivery system for hydrophobic drugs
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
MXPA06012909A (es) 2004-05-07 2007-09-06 Sequoia Pharmaceuticals Inc Inhibidores de proteasa retroviral repelente de resistencia.
MXPA06013314A (es) 2004-05-17 2007-02-02 Tibotec Pharm Ltd 1-heterociclil-1,5-dihidro-pirido[3,2-b]indol-2-onas.
TW200613307A (en) 2004-05-17 2006-05-01 Tibotec Pharm Ltd 4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones
US7622581B2 (en) 2004-05-17 2009-11-24 Tibotec Pharmaceuticals Ltd. 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
WO2006026504A2 (en) * 2004-08-27 2006-03-09 Spherics, Inc. Mucoadhesive oral formulations of high permeability, high solubility drugs
US20100297251A1 (en) * 2004-09-01 2010-11-25 Board Of Regents, The University Of Texas System Encapsulated particles for enteric release
US20060045822A1 (en) * 2004-09-01 2006-03-02 Board Of Regents, The University Of Texas System Plasma polymerization for encapsulating particles
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
TW200710091A (en) 2005-04-11 2007-03-16 Tibotec Pharm Ltd (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
JP2009502258A (ja) * 2005-07-21 2009-01-29 ノミール・メディカル・テクノロジーズ・インコーポレーテッド 標的部位の生物学的汚染物質のレベルを下げる方法
US20070148240A1 (en) * 2005-12-23 2007-06-28 Fang-Yu Lee Oral formulation containing itraconazole and methods for manufacturing and using the same
EP2004647A1 (en) 2006-04-03 2008-12-24 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 3,4-dihydro-imidazoý4,5-b¨pyridin-5-ones
CN101091725A (zh) * 2006-06-23 2007-12-26 天津天士力制药股份有限公司 一种中药颗粒及其制备方法
WO2008110534A1 (en) * 2007-03-13 2008-09-18 Sandoz Ag Pharmaceutical compositions of poorly soluble drugs
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
US7314641B1 (en) 2007-04-18 2008-01-01 Everest Pharm. Industrial Co., Ltd. High-bioavailability particle coated with fungicide and polymer
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
CA2707161C (en) 2007-11-28 2016-08-16 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome p450 2d6
CA2716348C (en) 2008-02-21 2017-04-04 Sequoia Pharmaceuticals, Inc. Diamide inhibitors of cytochrome p450
US8088451B2 (en) 2008-03-13 2012-01-03 Board Of Regents, The University Of Texas System Covalently functionalized particles for synthesis of new composite materials
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
GB2479213B (en) 2010-04-01 2013-07-10 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
WO2011146077A1 (en) * 2010-05-21 2011-11-24 Board Of Regents, The University Of Texas System Encapsulated particles for amorphous stability enhancement
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
NZ613167A (en) * 2010-12-16 2015-09-25 Univ Texas Azole pharmaceutical formulations for parenteral administration and methods for preparing and using the same as treatment of diseases sensitive to azole compounds
EP2706997B1 (en) 2011-05-10 2019-03-27 TheraVida, Inc. Combinations of solifenacin and pilocarpine for the treatment of overactive bladder
WO2013192566A1 (en) 2012-06-21 2013-12-27 Mayne Pharma International Pty. Ltd. Itraconazole compositions and dosage forms, and methods of using the same
CN103948911B (zh) * 2014-04-23 2016-04-20 深圳市健元医药科技有限公司 一种棘白菌素类抗真菌药物缓释微球制剂及其制备方法
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
CN108697688A (zh) 2016-01-20 2018-10-23 塞拉维达公司 用于治疗多汗症的方法和组合物
US20180147215A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US4916134A (en) * 1987-03-25 1990-04-10 Janssen Pharmacuetica N.V. 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
JPH01165520A (ja) * 1987-12-23 1989-06-29 Shin Etsu Chem Co Ltd 持続性製剤およびその製造方法
US5049374A (en) * 1989-11-28 1991-09-17 Dansereau Richard J Oral (coated bead) dosage form for sodium iodide I-131
US5213811A (en) * 1991-09-13 1993-05-25 Sterling Drug Inc. Oral sustained-release drug compositions

Also Published As

Publication number Publication date
AU4954693A (en) 1994-03-29
DE69306119D1 (de) 1997-01-02
JPH08501092A (ja) 1996-02-06
NO307953B1 (no) 2000-06-26
TW376322B (en) 1999-12-11
CZ54295A3 (en) 1995-09-13
NO950829L (no) 1995-05-02
HRP931158A2 (en) 1995-06-30
US5633015A (en) 1997-05-27
HU9500642D0 (en) 1995-04-28
PL174178B1 (pl) 1998-06-30
ES2097536T3 (es) 1997-04-01
IL106871A (en) 1998-02-22
FI950975A0 (fi) 1995-03-02
SI9300461A (en) 1994-03-31
HU220614B1 (hu) 2002-03-28
SG48801A1 (en) 1998-05-18
ZA936493B (en) 1995-03-02
HK1006000A1 (en) 1999-02-05
WO1994005263A1 (en) 1994-03-17
PL172676B1 (pl) 1997-11-28
EP0658103A1 (en) 1995-06-21
JP2865869B2 (ja) 1999-03-08
RU2125445C1 (ru) 1999-01-27
EP0658103B1 (en) 1996-11-20
CY2105B1 (en) 2002-04-26
AP444A (en) 1996-01-19
CN1034714C (zh) 1997-04-30
NZ255379A (en) 1996-06-25
CN1088432A (zh) 1994-06-29
CA2142848A1 (en) 1994-03-17
ATE145327T1 (de) 1996-12-15
DE69306119T2 (de) 1997-03-13
CA2142848C (en) 1999-11-16
AP9300563A0 (en) 1993-10-31
IL106871A0 (en) 1993-12-28
KR0151893B1 (ko) 1998-10-15
NO950829D0 (no) 1995-03-02
CZ283403B6 (cs) 1998-04-15
DK0658103T3 (da) 1996-12-09
HRP931158B1 (en) 1999-02-28
PL307791A1 (en) 1995-06-26
MX9305438A (es) 1994-03-31
FI112437B (fi) 2003-12-15
GR3022198T3 (en) 1997-03-31
PH30929A (en) 1997-12-23
SI9300461B (en) 2001-12-31
FI950975A (fi) 1995-03-02
HUT70419A (en) 1995-10-30
MY109369A (en) 1997-01-31
AU665867B2 (en) 1996-01-18

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