NZ751189A - Pd-1 homing endonuclease variants, compositions, and methods of use - Google Patents

Pd-1 homing endonuclease variants, compositions, and methods of use

Info

Publication number
NZ751189A
NZ751189A NZ751189A NZ75118917A NZ751189A NZ 751189 A NZ751189 A NZ 751189A NZ 751189 A NZ751189 A NZ 751189A NZ 75118917 A NZ75118917 A NZ 75118917A NZ 751189 A NZ751189 A NZ 751189A
Authority
NZ
New Zealand
Prior art keywords
methods
compositions
homing endonuclease
gene
amino acid
Prior art date
Application number
NZ751189A
Other languages
English (en)
Inventor
Jasdeep Mann
Joel Gay
Jordan Jarjour
Joy Zhang
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of NZ751189A publication Critical patent/NZ751189A/en

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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NZ751189A 2016-09-08 2017-09-08 Pd-1 homing endonuclease variants, compositions, and methods of use NZ751189A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662385079P 2016-09-08 2016-09-08
US201662414279P 2016-10-28 2016-10-28
PCT/US2017/050774 WO2018049226A1 (en) 2016-09-08 2017-09-08 Pd-1 homing endonuclease variants, compositions, and methods of use

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NZ751189A true NZ751189A (en) 2026-03-27

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US (3) US11365226B2 (https=)
EP (2) EP3510157B1 (https=)
JP (2) JP7356346B2 (https=)
KR (2) KR102622910B1 (https=)
CN (1) CN109923211A (https=)
AU (1) AU2017323629B9 (https=)
BR (1) BR112019004629A2 (https=)
CA (1) CA3035455A1 (https=)
DK (1) DK3510157T5 (https=)
ES (1) ES2952525T3 (https=)
IL (1) IL265045B2 (https=)
MA (1) MA46389A (https=)
MX (1) MX2019002725A (https=)
NZ (1) NZ751189A (https=)
SG (1) SG11201901757YA (https=)
WO (1) WO2018049226A1 (https=)

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