NZ630591A - Microrna compounds and methods for modulating mir-21 activity - Google Patents

Microrna compounds and methods for modulating mir-21 activity

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Publication number
NZ630591A
NZ630591A NZ630591A NZ63059113A NZ630591A NZ 630591 A NZ630591 A NZ 630591A NZ 630591 A NZ630591 A NZ 630591A NZ 63059113 A NZ63059113 A NZ 63059113A NZ 630591 A NZ630591 A NZ 630591A
Authority
NZ
New Zealand
Prior art keywords
activity
methods
mir
modified oligonucleotide
modulating mir
Prior art date
Application number
NZ630591A
Other languages
English (en)
Inventor
Balkrishen Bhat
Eric Marcusson
Original Assignee
Regulus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48289681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ630591(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regulus Therapeutics Inc filed Critical Regulus Therapeutics Inc
Publication of NZ630591A publication Critical patent/NZ630591A/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/141—MicroRNAs, miRNAs
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  • Wood Science & Technology (AREA)
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  • Diabetes (AREA)
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NZ630591A 2012-04-25 2013-04-24 Microrna compounds and methods for modulating mir-21 activity NZ630591A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261741783P 2012-04-25 2012-04-25
US201261717927P 2012-10-24 2012-10-24
US201361779913P 2013-03-13 2013-03-13
PCT/US2013/037913 WO2013163258A1 (en) 2012-04-25 2013-04-24 Microrna compounds and methods for modulating mir-21 activity

Publications (1)

Publication Number Publication Date
NZ630591A true NZ630591A (en) 2017-02-24

Family

ID=48289681

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ630591A NZ630591A (en) 2012-04-25 2013-04-24 Microrna compounds and methods for modulating mir-21 activity

Country Status (28)

Country Link
US (5) US8969317B2 (Direct)
EP (1) EP2841579B1 (Direct)
JP (1) JP6322189B2 (Direct)
KR (4) KR20230037703A (Direct)
CN (1) CN104254607B (Direct)
AR (1) AR090825A1 (Direct)
AU (1) AU2013251696B2 (Direct)
BR (1) BR112014026639A8 (Direct)
CA (1) CA2869639A1 (Direct)
CL (3) CL2014002844A1 (Direct)
CO (1) CO7111303A2 (Direct)
CR (1) CR20140524A (Direct)
DO (1) DOP2014000233A (Direct)
EA (1) EA030211B1 (Direct)
EC (1) ECSP14028612A (Direct)
GT (1) GT201400221A (Direct)
IL (1) IL234904B (Direct)
IN (1) IN2014DN09134A (Direct)
MX (1) MX353562B (Direct)
MY (1) MY173600A (Direct)
NZ (1) NZ630591A (Direct)
PE (1) PE20142404A1 (Direct)
PH (2) PH12023550488A1 (Direct)
SG (1) SG11201406931XA (Direct)
TW (1) TWI647235B (Direct)
UA (1) UA117098C2 (Direct)
WO (1) WO2013163258A1 (Direct)
ZA (1) ZA201407228B (Direct)

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ES2737960T3 (es) 2010-10-01 2020-01-17 Modernatx Inc Nucleósidos, nucleótidos y ácidos nucleicos modificados y sus usos
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
PT2702155T (pt) 2011-04-25 2017-04-03 Regulus Therapeutics Inc Compostos de microrna e métodos para modular a atividade de mir-21
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CN110511939A (zh) 2011-10-03 2019-11-29 现代泰克斯公司 修饰的核苷、核苷酸和核酸及其用途
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JP2015518475A (ja) * 2012-04-10 2015-07-02 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） 非アルコール性脂肪性肝炎の治療方法
WO2013163258A1 (en) 2012-04-25 2013-10-31 Regulus Therapeutics Inc. Microrna compounds and methods for modulating mir-21 activity
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
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JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
WO2015061536A1 (en) * 2013-10-25 2015-04-30 Regulus Therapeutics Inc. Microrna compounds and methods for modulating mir-21 activity
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US9833416B2 (en) * 2014-04-04 2017-12-05 Ohio State Innovation Foundation Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
CN105087477A (zh) * 2015-05-21 2015-11-25 王松灵 miR-21反义核苷酸修饰的骨髓间充质干细胞的用途
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
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