NZ627188A - Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells - Google Patents

Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells

Info

Publication number
NZ627188A
NZ627188A NZ627188A NZ62718813A NZ627188A NZ 627188 A NZ627188 A NZ 627188A NZ 627188 A NZ627188 A NZ 627188A NZ 62718813 A NZ62718813 A NZ 62718813A NZ 627188 A NZ627188 A NZ 627188A
Authority
NZ
New Zealand
Prior art keywords
hematopoietic stem
anemia
pyrimido
stem cells
indole derivatives
Prior art date
Application number
NZ627188A
Other languages
English (en)
Inventor
Guy Sauvageau
Yves Gareau
Réjean Ruel
Stéphane Gingras
Iman Fares
Original Assignee
Univ Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48872865&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ627188(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Montreal filed Critical Univ Montreal
Publication of NZ627188A publication Critical patent/NZ627188A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NZ627188A 2012-01-27 2013-01-25 Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells NZ627188A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261591521P 2012-01-27 2012-01-27
PCT/CA2013/050052 WO2013110198A1 (en) 2012-01-27 2013-01-25 Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells

Publications (1)

Publication Number Publication Date
NZ627188A true NZ627188A (en) 2015-12-24

Family

ID=48872865

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ627188A NZ627188A (en) 2012-01-27 2013-01-25 Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells

Country Status (27)

Country Link
US (3) US9409906B2 (https=)
EP (1) EP2807165B1 (https=)
JP (1) JP6250556B2 (https=)
KR (1) KR102098122B1 (https=)
CN (1) CN104144931B (https=)
AU (1) AU2013212457B2 (https=)
BR (1) BR112014018524B1 (https=)
CA (1) CA2862140C (https=)
CY (1) CY1121799T1 (https=)
DK (1) DK2807165T3 (https=)
ES (1) ES2733946T3 (https=)
FR (1) FR26C1003I1 (https=)
HR (1) HRP20191189T1 (https=)
HU (1) HUE044070T4 (https=)
IL (1) IL233587B (https=)
LT (2) LT2807165T (https=)
NL (1) NL301363I2 (https=)
NO (1) NO2026005I1 (https=)
NZ (1) NZ627188A (https=)
PL (1) PL2807165T3 (https=)
PT (1) PT2807165T (https=)
RS (1) RS59002B1 (https=)
SG (1) SG11201404241SA (https=)
SI (1) SI2807165T1 (https=)
SM (1) SMT201900360T1 (https=)
TR (1) TR201909582T4 (https=)
WO (1) WO2013110198A1 (https=)

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US9757378B2 (en) 2013-05-17 2017-09-12 Universite De Montreal Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation
WO2015131005A1 (en) * 2014-02-28 2015-09-03 The Regents Of The University Of Michigan 9h-pyrimido[4,5-b]indoles and related analogs as bet bromodomain inhibitors
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JP6795493B2 (ja) * 2014-09-18 2020-12-02 ウニヴェルシテ ド モントリオール ヒト造血細胞へのウイルス遺伝子導入を増強させるための化合物および方法
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Also Published As

Publication number Publication date
JP2015504902A (ja) 2015-02-16
US10336747B2 (en) 2019-07-02
SG11201404241SA (en) 2014-08-28
LTPA2026503I1 (https=) 2026-02-10
US20150011543A1 (en) 2015-01-08
IL233587B (en) 2019-11-28
FR26C1003I1 (fr) 2026-03-06
BR112014018524A2 (pt) 2021-06-08
IL233587A0 (en) 2014-08-31
US20160222017A1 (en) 2016-08-04
CY1121799T1 (el) 2020-07-31
HUE044070T2 (hu) 2019-09-30
SI2807165T1 (sl) 2019-08-30
TR201909582T4 (tr) 2019-07-22
AU2013212457A1 (en) 2014-09-18
NO2026005I1 (no) 2026-01-21
CN104144931A (zh) 2014-11-12
EP2807165A1 (en) 2014-12-03
NL301363I2 (nl) 2026-02-19
KR102098122B1 (ko) 2020-04-07
DK2807165T3 (da) 2019-07-15
SMT201900360T1 (it) 2019-07-11
LT2807165T (lt) 2019-07-25
CA2862140C (en) 2020-04-21
HUE044070T4 (hu) 2019-12-30
CN104144931B (zh) 2018-04-10
JP6250556B2 (ja) 2017-12-20
BR112014018524B1 (pt) 2023-03-28
EP2807165A4 (en) 2015-08-26
US20170334904A1 (en) 2017-11-23
PT2807165T (pt) 2019-07-12
AU2013212457B2 (en) 2017-02-16
KR20140121454A (ko) 2014-10-15
ES2733946T3 (es) 2019-12-03
CA2862140A1 (en) 2013-08-01
EP2807165B1 (en) 2019-05-15
RS59002B1 (sr) 2019-08-30
BR112014018524A8 (pt) 2017-07-11
HK1203945A1 (en) 2015-11-06
US9409906B2 (en) 2016-08-09
HRP20191189T1 (hr) 2019-10-04
PL2807165T3 (pl) 2019-09-30
WO2013110198A1 (en) 2013-08-01

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