NZ611476A - Topical localized isoxazoline formulation - Google Patents

Topical localized isoxazoline formulation

Info

Publication number
NZ611476A
NZ611476A NZ611476A NZ61147611A NZ611476A NZ 611476 A NZ611476 A NZ 611476A NZ 611476 A NZ611476 A NZ 611476A NZ 61147611 A NZ61147611 A NZ 61147611A NZ 611476 A NZ611476 A NZ 611476A
Authority
NZ
New Zealand
Prior art keywords
topical localized
methyl
solvent
formula
liquid carrier
Prior art date
Application number
NZ611476A
Other languages
English (en)
Inventor
Stefan Fuchs
Anja Regina Heckeroth
Ramona Müller
Heike Williams
Hartmut Zoller
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43971048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ611476(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of NZ611476A publication Critical patent/NZ611476A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NZ611476A 2010-12-27 2011-12-22 Topical localized isoxazoline formulation NZ611476A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10197089 2010-12-27
US201161430240P 2011-01-06 2011-01-06
PCT/EP2011/073828 WO2012089622A2 (en) 2010-12-27 2011-12-22 Topical localized isoxazoline formulation

Publications (1)

Publication Number Publication Date
NZ611476A true NZ611476A (en) 2015-10-30

Family

ID=43971048

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ611476A NZ611476A (en) 2010-12-27 2011-12-22 Topical localized isoxazoline formulation

Country Status (19)

Country Link
US (4) US9173870B2 (enExample)
EP (1) EP2658542B2 (enExample)
JP (3) JP6002148B2 (enExample)
KR (2) KR20130130761A (enExample)
CN (2) CN105616406B (enExample)
AU (2) AU2016201954B2 (enExample)
BR (1) BR112013015503A2 (enExample)
CA (1) CA2822839C (enExample)
DK (1) DK2658542T4 (enExample)
ES (1) ES2908094T5 (enExample)
FI (1) FI2658542T4 (enExample)
HU (1) HUE058291T2 (enExample)
MX (2) MX383895B (enExample)
NZ (1) NZ611476A (enExample)
PL (1) PL2658542T5 (enExample)
PT (1) PT2658542T (enExample)
RU (2) RU2749733C2 (enExample)
WO (1) WO2012089622A2 (enExample)
ZA (1) ZA201304514B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105616406B (zh) 2010-12-27 2019-12-13 英特维特国际股份有限公司 外用局部异噁唑啉制剂
RU2602189C2 (ru) * 2010-12-27 2016-11-10 Интервет Интернэшнл Б.В. Изоксазолиновый состав, содержащий гликофурол для наружного и местного применения
DK3172964T3 (da) 2011-09-12 2020-11-30 Boehringer Ingelheim Animal Health Usa Inc Parasitiske sammensætninger indeholdende et isoxazolinaktivstof, fremgangsmåde og anvendelser deraf
RU2763496C2 (ru) 2012-02-06 2021-12-29 БЁРИНГЕР ИНГЕЛЬХАЙМ ЭНИМАЛ ХЕЛТ ЮЭсЭй ИНК. Паразитицидные пероральные ветеринарные композиции, включающие системно действующие активные агенты, способы и применение этих композиций и способов
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
CN108685894B (zh) * 2012-04-04 2022-04-26 英特维特国际股份有限公司 软咀嚼药用产品
AU2014342241B2 (en) 2013-11-01 2017-09-14 Boehringer Ingelheim Animal Health USA Inc. Antiparasitic and pesticidal isoxazoline compounds
HUE055444T2 (hu) 2013-12-20 2021-11-29 Intervet Int Bv Izoxazolinszármazákok felhasználása baromfiak arthropodafertõzéseinek kezelésére vagy megelõzésére
ES2971061T3 (es) 2013-12-20 2024-06-03 Intervet Int Bv Composiciones de isoxazolina y uso de las mismas en la prevención o el tratamiento de infestaciones parasitarias en animales
CN106455560B (zh) 2014-04-17 2020-12-22 勃林格殷格翰动物保健美国公司 用于保护动物免受寄生物的丙二腈化合物的用途
US20170232024A1 (en) 2014-08-04 2017-08-17 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
US20170348286A1 (en) 2014-12-22 2017-12-07 Intervet Inc. Use of isoxazoline compounds for treating demodicosis
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
HUE055535T2 (hu) 2015-05-20 2021-12-28 Boehringer Ingelheim Animal Health Usa Inc Féreghajtó depszipeptid-vegyületek
US20170333305A1 (en) * 2016-05-23 2017-11-23 Microban Products Company Topical skin product having retention property
CN110381738B (zh) 2016-10-14 2021-07-16 勃林格殷格翰动物保健美国公司 农药的和杀寄生物的乙烯基异噁唑啉化合物
JP2020504710A (ja) 2016-11-16 2020-02-13 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性デプシペプチド化合物
JP2020530850A (ja) 2017-08-14 2020-10-29 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺有害生物および殺寄生生物ピラゾール−イソキサゾリン化合物
CA3082048A1 (en) * 2017-11-23 2019-05-31 Ceva Sante Animale Composition containing moxidectin for treating parasites infestations
MX2020006309A (es) 2017-12-15 2021-01-29 Tarsus Pharmaceuticals Inc Fórmulaciones de parasiticida de isoxazolina y métodos para el tratamiento de la blefaritis.
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
IL279977B2 (en) 2018-07-09 2024-06-01 Boehringer Ingelheim Animal Health Usa Inc Heterocyclic anthelmintic compounds
EP3883648A1 (en) 2018-11-20 2021-09-29 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
KR102079347B1 (ko) * 2018-11-30 2020-02-19 문현규 치과용 유닛 체어
WO2020191091A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
CA3138263A1 (en) * 2019-05-03 2020-11-12 Intervet International B.V. Injectable pharmaceutical compositions and uses thereof
FR3107531B1 (fr) * 2020-02-20 2022-02-25 Rl Innovation .composition liquide ou en gel, ecologique permettant l’enlevement des graffittis, chewing-gums, colles, resines sur tous supports poreux ou non ainsi que tous marquages routier
US11964977B2 (en) 2020-05-29 2024-04-23 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
JP7724845B2 (ja) 2020-07-24 2025-08-18 エランコ・ユーエス・インコーポレイテッド イソオキサゾリン化合物及びその中間体を作製するための方法
CH717763A2 (de) 2020-08-18 2022-02-28 Swibox Ag Abzweigsystem für elektrische Leiter.
US20240116854A1 (en) 2021-01-27 2024-04-11 Intervet Inc. Cyclopropylamide compounds against parasites in fish
EP4284175A1 (en) 2021-01-27 2023-12-06 Intervet International B.V. Cyclopropylamide compounds against parasites in fish
US12258193B2 (en) 2022-02-17 2025-03-25 Boehringer Ingelheim Vetmedica Gmbh Method and system for providing a fluid product mailer
NO20240925A1 (en) 2023-09-15 2025-03-17 Evah Atlantic Inc Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish
WO2025191150A2 (en) 2024-03-15 2025-09-18 Krka, D.D., Novo Mesto Stable isoxazoline formulation for topical application to the skin

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3984564A (en) 1972-06-08 1976-10-05 Sankyo Company Limited Antibiotic substances B-41, their production and their use as insecticides and acaricides
JPS60218303A (ja) 1984-04-13 1985-11-01 Mitsubishi Chem Ind Ltd 忌避剤組成物
US4916154A (en) 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
IL98599A (en) 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of 4"-deoxy-4"-epi-methylamino avermectin b1a/b1b and insecticidal compositions containing them
JPH04217606A (ja) * 1990-11-30 1992-08-07 Mitsubishi Gas Chem Co Inc 吸血害虫の吸血阻害剤
US5874479A (en) 1991-03-01 1999-02-23 Warner-Lambert Company Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same
US5399717A (en) 1993-09-29 1995-03-21 Merck & Co., Inc. Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1
US20050233945A1 (en) * 2003-07-18 2005-10-20 Larry Brown Methods for fabrication, uses and compositions of small spherical particles of insulin prepared by controlled phase separation
US7906128B2 (en) * 2002-10-21 2011-03-15 Wyeth Llc Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals
US8119150B2 (en) * 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US7422215B2 (en) 2003-10-08 2008-09-09 Seven Generations, Inc. Biased card deal
CN102558082B (zh) 2004-03-05 2015-09-30 日产化学工业株式会社 异噁唑啉取代苯甲酰胺化合物的制备中间体
PE20060785A1 (es) * 2004-10-08 2006-09-19 Wyeth Corp Composiciones de amitraz
CN100566566C (zh) * 2004-10-08 2009-12-09 惠氏公司 三亚螨（amitraz）组合物
TWI368505B (en) 2005-05-24 2012-07-21 Wyeth Corp Versatile high load concentrate compositions for control of ecto-parasites
US7749527B2 (en) 2005-05-24 2010-07-06 Wyeth Llc Gel compositions for control of ecto-parasites
US20060293260A1 (en) † 2005-05-24 2006-12-28 Wyeth Useful high load concentrate compositions for control of ecto-and endo-parasites
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
CN101454272A (zh) * 2006-05-31 2009-06-10 国立大学法人北海道大学 具有全氟烷基的氟代胺及其制备方法和使用了它的氟化方法以及具有全氟烷基的酰胺的回收方法
TW200846029A (en) † 2007-02-09 2008-12-01 Wyeth Corp High dose, long-acting ectoparasiticide for extended control
CL2008001614A1 (es) 2007-06-05 2008-08-08 Wyeth Corp Composicion parasiticida veterinaria que comprende un disolvente que no contiene hidroxilo, un estabilizador, amitraz y opcionalmente una lactona macrociclica y miristato de isopropilo; y su uso para tratar o controlar una infestacion o infeccion par
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX368680B (es) 2007-06-27 2019-10-11 Du Pont Administración subcutánea de un derivado de isoxazol-benzamida para usarse en un método para proteger un mamífero de una pulga.
TWI556741B (zh) * 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
CA2747060A1 (en) 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
TWI454472B (zh) 2008-12-19 2014-10-01 Novartis Ag 有機化合物
WO2010096623A1 (en) * 2009-02-23 2010-08-26 Wyeth Llc Improved-scent ectoparasiticidal formulation
UA108219C2 (uk) 2009-12-17 2015-04-10 Протипаразитарні дигідроазолові сполуки та композиція, яка їх містить (варіанти)
CN101780020B (zh) * 2010-02-09 2011-12-28 广东名臣有限公司 一种清凉、止痒、驱蚊的花露水
CN102933563A (zh) 2010-04-08 2013-02-13 Ah美国42有限责任公司 作为杀虫剂和杀螨剂的取代的3,5-二苯基异噁唑啉衍生物
CN105616406B (zh) 2010-12-27 2019-12-13 英特维特国际股份有限公司 外用局部异噁唑啉制剂
RU2602189C2 (ru) 2010-12-27 2016-11-10 Интервет Интернэшнл Б.В. Изоксазолиновый состав, содержащий гликофурол для наружного и местного применения
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments

Also Published As

Publication number Publication date
CN103260621A (zh) 2013-08-21
FI2658542T4 (fi) 2025-09-02
US9173870B2 (en) 2015-11-03
RU2633061C2 (ru) 2017-10-11
JP6002148B2 (ja) 2016-10-05
RU2013135280A (ru) 2015-02-10
AU2017254818A1 (en) 2017-11-16
JP6246864B2 (ja) 2017-12-13
EP2658542B1 (en) 2022-01-26
PT2658542T (pt) 2022-03-10
EP2658542A2 (en) 2013-11-06
DK2658542T3 (da) 2022-03-28
BR112013015503A2 (pt) 2017-06-27
AU2017254818B2 (en) 2019-08-01
US10864195B2 (en) 2020-12-15
CN103260621B (zh) 2016-08-24
US20130281501A1 (en) 2013-10-24
CN105616406B (zh) 2019-12-13
KR20130130761A (ko) 2013-12-02
US9532978B2 (en) 2017-01-03
PL2658542T3 (pl) 2022-06-20
JP2016222691A (ja) 2016-12-28
AU2016201954B2 (en) 2017-11-23
US20160015689A1 (en) 2016-01-21
US20180085352A1 (en) 2018-03-29
HUE058291T2 (hu) 2022-07-28
KR20180125037A (ko) 2018-11-21
MX356926B (es) 2018-06-19
CA2822839C (en) 2020-12-29
CN105616406A (zh) 2016-06-01
AU2016201954A1 (en) 2016-04-21
PL2658542T5 (pl) 2025-07-28
JP2014504586A (ja) 2014-02-24
AU2011351578A1 (en) 2013-06-20
EP2658542B2 (en) 2025-06-04
JP2018048194A (ja) 2018-03-29
RU2017118161A3 (enExample) 2020-07-30
WO2012089622A3 (en) 2012-11-15
DK2658542T4 (da) 2025-08-25
RU2017118161A (ru) 2018-10-30
CA2822839A1 (en) 2012-07-05
JP6514754B2 (ja) 2019-05-15
ZA201304514B (en) 2014-03-26
ES2908094T5 (en) 2025-08-12
WO2012089622A2 (en) 2012-07-05
RU2749733C2 (ru) 2021-06-16
ES2908094T3 (es) 2022-04-27
MX383895B (es) 2025-03-14
US20170071914A1 (en) 2017-03-16
MX2013007500A (es) 2013-08-01
KR102027723B1 (ko) 2019-10-01

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