AU2016201954B2 - Topical localized isoxazoline formulation - Google Patents

Topical localized isoxazoline formulation Download PDF

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Publication number
AU2016201954B2
AU2016201954B2 AU2016201954A AU2016201954A AU2016201954B2 AU 2016201954 B2 AU2016201954 B2 AU 2016201954B2 AU 2016201954 A AU2016201954 A AU 2016201954A AU 2016201954 A AU2016201954 A AU 2016201954A AU 2016201954 B2 AU2016201954 B2 AU 2016201954B2
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AU
Australia
Prior art keywords
spot
compound
formulation
pour
formulations
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AU2016201954A
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English (en)
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AU2016201954A1 (en
Inventor
Stefan Fuchs
Anja Regina Heckeroth
Ramona Muller
Heike Williams
Hartmut Zoller
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Intervet International BV
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Intervet International BV
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43971048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2016201954(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from AU2011351578A external-priority patent/AU2011351578B2/en
Application filed by Intervet International BV filed Critical Intervet International BV
Priority to AU2016201954A priority Critical patent/AU2016201954B2/en
Publication of AU2016201954A1 publication Critical patent/AU2016201954A1/en
Priority to AU2017254818A priority patent/AU2017254818B2/en
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Publication of AU2016201954B2 publication Critical patent/AU2016201954B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2016201954A 2010-12-27 2016-03-30 Topical localized isoxazoline formulation Active AU2016201954B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2016201954A AU2016201954B2 (en) 2010-12-27 2016-03-30 Topical localized isoxazoline formulation
AU2017254818A AU2017254818B2 (en) 2010-12-27 2017-10-30 Topical localized isoxazoline formulation

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP10197089 2010-12-27
EP10197089.5 2010-12-27
US201161430240P 2011-01-06 2011-01-06
US61/430,240 2011-01-06
PCT/EP2011/073828 WO2012089622A2 (en) 2010-12-27 2011-12-22 Topical localized isoxazoline formulation
AU2011351578A AU2011351578B2 (en) 2010-12-27 2011-12-22 Topical localized isoxazoline formulation
AU2016201954A AU2016201954B2 (en) 2010-12-27 2016-03-30 Topical localized isoxazoline formulation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2011351578A Division AU2011351578B2 (en) 2010-12-27 2011-12-22 Topical localized isoxazoline formulation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017254818A Division AU2017254818B2 (en) 2010-12-27 2017-10-30 Topical localized isoxazoline formulation

Publications (2)

Publication Number Publication Date
AU2016201954A1 AU2016201954A1 (en) 2016-04-21
AU2016201954B2 true AU2016201954B2 (en) 2017-11-23

Family

ID=43971048

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016201954A Active AU2016201954B2 (en) 2010-12-27 2016-03-30 Topical localized isoxazoline formulation
AU2017254818A Active AU2017254818B2 (en) 2010-12-27 2017-10-30 Topical localized isoxazoline formulation

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017254818A Active AU2017254818B2 (en) 2010-12-27 2017-10-30 Topical localized isoxazoline formulation

Country Status (19)

Country Link
US (4) US9173870B2 (enExample)
EP (1) EP2658542B2 (enExample)
JP (3) JP6002148B2 (enExample)
KR (2) KR102027723B1 (enExample)
CN (2) CN103260621B (enExample)
AU (2) AU2016201954B2 (enExample)
BR (1) BR112013015503A2 (enExample)
CA (1) CA2822839C (enExample)
DK (1) DK2658542T4 (enExample)
ES (1) ES2908094T5 (enExample)
FI (1) FI2658542T4 (enExample)
HU (1) HUE058291T2 (enExample)
MX (2) MX356926B (enExample)
NZ (1) NZ611476A (enExample)
PL (1) PL2658542T5 (enExample)
PT (1) PT2658542T (enExample)
RU (2) RU2749733C2 (enExample)
WO (1) WO2012089622A2 (enExample)
ZA (1) ZA201304514B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12390450B2 (en) 2017-12-21 2025-08-19 Intervet Inc. Antiparasitic pour-on compositions

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2658542T4 (da) * 2010-12-27 2025-08-25 Intervet Int Bv Topisk lokaliseret isoxazolinformulering
PL2658541T3 (pl) * 2010-12-27 2022-04-04 Intervet International B.V. Preparat izoksazoliny do stosowania miejscowego zawierający glikofurol
CN106474120B (zh) 2011-09-12 2020-07-28 勃林格殷格翰动物保健美国公司 包含异噁唑啉活性剂的杀寄生物组合物，其方法和用途
FI128926B (en) 2012-02-06 2021-03-15 Merial Ltd Parasiticidal oral veterinary composition compositions comprising a systemically active agent for the treatment and / or prevention of a parasitic infection or infection in an animal
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
BR112014024833B1 (pt) 2012-04-04 2022-10-04 Intervet International B.V. Produto farmacêutico veterinário mastigável macio, processo para sua fabricação e seu uso, bem como uso de pamoato de sódio
NZ719916A (en) 2013-11-01 2017-09-29 Merial Inc Antiparasitic and pesticidal isoxazoline compounds
JP6581586B2 (ja) * 2013-12-20 2019-09-25 インターベット インターナショナル ベー． フェー． イソオキサゾリン組成物および動物における寄生虫侵襲の予防または処置におけるその使用
WO2015091900A1 (en) 2013-12-20 2015-06-25 Intervet International B.V. Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry
CN106455560B (zh) 2014-04-17 2020-12-22 勃林格殷格翰动物保健美国公司 用于保护动物免受寄生物的丙二腈化合物的用途
US20170232024A1 (en) 2014-08-04 2017-08-17 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
CN114681453A (zh) 2014-12-22 2022-07-01 英特维特国际股份有限公司 异噁唑啉化合物用于治疗蠕形螨病的用途
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
MX379719B (es) 2015-05-20 2025-03-11 Boehringer Ingelheim Animal Health Usa Inc Compuestos depsipeptidicos como anthelmínticos.
US20170333305A1 (en) * 2016-05-23 2017-11-23 Microban Products Company Topical skin product having retention property
CN110381738B (zh) 2016-10-14 2021-07-16 勃林格殷格翰动物保健美国公司 农药的和杀寄生物的乙烯基异噁唑啉化合物
BR112019009977A2 (pt) 2016-11-16 2019-08-27 Boehringer Ingelheim Animal Health Usa Inc compostos depsipeptídicos anti-helmínticos
ES2944616T3 (es) 2017-08-14 2023-06-22 Boehringer Ingelheim Animal Health Usa Inc Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas
BR112020010291A2 (pt) * 2017-11-23 2020-11-17 Ceva Sante Animale composição contendo moxidectina para tratamento de infestações de parasitas
CN119174758A (zh) 2017-12-15 2024-12-24 塔苏斯制药有限公司 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法
EP3820870A1 (en) 2018-07-09 2021-05-19 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic heterocyclic compounds
US11773066B2 (en) 2018-11-20 2023-10-03 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
KR102079347B1 (ko) * 2018-11-30 2020-02-19 문현규 치과용 유닛 체어
CN119285648A (zh) 2019-03-19 2025-01-10 勃林格殷格翰动物保健有限公司 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
WO2020225143A1 (en) * 2019-05-03 2020-11-12 Intervet International B.V. Injectable pharmaceutical compositions and uses thereof
WO2021127188A1 (en) 2019-12-18 2021-06-24 Elanco Tiergesundheit Ag Isoxazoline derivatives as pesticides
FR3107531B1 (fr) * 2020-02-20 2022-02-25 Rl Innovation .composition liquide ou en gel, ecologique permettant l’enlevement des graffittis, chewing-gums, colles, resines sur tous supports poreux ou non ainsi que tous marquages routier
CR20220665A (es) 2020-05-29 2023-07-19 Boehringer Ingelheim Pharma Compuestos heterocíclicos como anthelmínticos
EP4185585A1 (en) 2020-07-24 2023-05-31 Elanco Us Inc. Process for making an isoxazoline compound and intermediate thereof
CH717763A2 (de) 2020-08-18 2022-02-28 Swibox Ag Abzweigsystem für elektrische Leiter.
US20240116854A1 (en) 2021-01-27 2024-04-11 Intervet Inc. Cyclopropylamide compounds against parasites in fish
CA3209562A1 (en) 2021-01-27 2022-08-04 Intervet International B.V. Cyclopropylamide compounds against parasites in fish
JP2025507585A (ja) 2022-02-17 2025-03-21 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 流体製品メーラーを提供する方法及びシステム
NO20240925A1 (en) 2023-09-15 2025-03-17 Evah Atlantic Inc Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish
WO2025191150A2 (en) 2024-03-15 2025-09-18 Krka, D.D., Novo Mesto Stable isoxazoline formulation for topical application to the skin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040116419A1 (en) * 2002-10-21 2004-06-17 Wyeth Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals
WO2006042099A1 (en) * 2004-10-08 2006-04-20 Wyeth Amitraz compositions
WO2009024541A2 (en) * 2007-08-17 2009-02-26 Intervet International B.V. Isoxazoline compositions and their use as antiparasitics

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3984564A (en) 1972-06-08 1976-10-05 Sankyo Company Limited Antibiotic substances B-41, their production and their use as insecticides and acaricides
JPS60218303A (ja) * 1984-04-13 1985-11-01 Mitsubishi Chem Ind Ltd 忌避剤組成物
US4916154A (en) 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
IL98599A (en) 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of 4"-deoxy-4"-epi-methylamino avermectin b1a/b1b and insecticidal compositions containing them
JPH04217606A (ja) * 1990-11-30 1992-08-07 Mitsubishi Gas Chem Co Inc 吸血害虫の吸血阻害剤
US5874479A (en) 1991-03-01 1999-02-23 Warner-Lambert Company Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same
US5399717A (en) 1993-09-29 1995-03-21 Merck & Co., Inc. Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1
US8119150B2 (en) * 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
EP1646445A4 (en) 2003-07-18 2007-09-19 Baxter Int METHOD OF MANUFACTURING, USING AND COMPOSING SMALL BALLULAR PARTICLES PRODUCED BY CONTROLLED PHASE SEPARATION
US7422215B2 (en) 2003-10-08 2008-09-09 Seven Generations, Inc. Biased card deal
WO2005085216A1 (ja) 2004-03-05 2005-09-15 Nissan Chemical Industries, Ltd. イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
CN100566566C (zh) * 2004-10-08 2009-12-09 惠氏公司 三亚螨（amitraz）组合物
US7749527B2 (en) 2005-05-24 2010-07-06 Wyeth Llc Gel compositions for control of ecto-parasites
TWI368505B (en) 2005-05-24 2012-07-21 Wyeth Corp Versatile high load concentrate compositions for control of ecto-parasites
US20060293260A1 (en) 2005-05-24 2006-12-28 Wyeth Useful high load concentrate compositions for control of ecto-and endo-parasites
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
JPWO2007139182A1 (ja) * 2006-05-31 2009-10-15 国立大学法人 北海道大学 パーフルオロアルキル基を有するフルオロアミン、その製造方法及びそれを用いるフッ素化方法、並びにパーフルオロアルキル基を有するアミドの回収方法
TW200846029A (en) 2007-02-09 2008-12-01 Wyeth Corp High dose, long-acting ectoparasiticide for extended control
CL2008001614A1 (es) 2007-06-05 2008-08-08 Wyeth Corp Composicion parasiticida veterinaria que comprende un disolvente que no contiene hidroxilo, un estabilizador, amitraz y opcionalmente una lactona macrociclica y miristato de isopropilo; y su uso para tratar o controlar una infestacion o infeccion par
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
EP2957284B1 (en) 2007-06-27 2018-01-17 E. I. du Pont de Nemours and Company Animal pest control method
ES2442342T3 (es) 2008-12-18 2014-02-11 Novartis Ag Derivados de las isoxazolinas y su uso como pesticida
US8383659B2 (en) 2008-12-19 2013-02-26 Novartis Ag Isoxazoline derivatives as pesticides
CN102325448A (zh) 2009-02-23 2012-01-18 惠氏有限责任公司 改善气味的杀体外寄生虫制剂
DK3078664T3 (da) 2009-12-17 2019-05-13 Merial Inc Antiparasitiske dihydroazol-sammensætninger
CN101780020B (zh) * 2010-02-09 2011-12-28 广东名臣有限公司 一种清凉、止痒、驱蚊的花露水
WO2011124998A1 (en) 2010-04-08 2011-10-13 Pfizer Inc. Substituted 3,5- di phenyl - isoxazoline derivatives as insecticides and acaricides
PL2658541T3 (pl) 2010-12-27 2022-04-04 Intervet International B.V. Preparat izoksazoliny do stosowania miejscowego zawierający glikofurol
DK2658542T4 (da) 2010-12-27 2025-08-25 Intervet Int Bv Topisk lokaliseret isoxazolinformulering
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040116419A1 (en) * 2002-10-21 2004-06-17 Wyeth Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals
WO2006042099A1 (en) * 2004-10-08 2006-04-20 Wyeth Amitraz compositions
WO2009024541A2 (en) * 2007-08-17 2009-02-26 Intervet International B.V. Isoxazoline compositions and their use as antiparasitics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12390450B2 (en) 2017-12-21 2025-08-19 Intervet Inc. Antiparasitic pour-on compositions

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