NZ602981A - NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES - Google Patents
NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVESInfo
- Publication number
- NZ602981A NZ602981A NZ602981A NZ60298111A NZ602981A NZ 602981 A NZ602981 A NZ 602981A NZ 602981 A NZ602981 A NZ 602981A NZ 60298111 A NZ60298111 A NZ 60298111A NZ 602981 A NZ602981 A NZ 602981A
- Authority
- NZ
- New Zealand
- Prior art keywords
- spp
- difluoroethyl
- pyrrolo
- phenyl
- compounds
- Prior art date
Links
- LBZJYBQJOOMCGP-UHFFFAOYSA-N 1-[4-(2,2-difluoroethyl)phenyl]-6h-pyrrolo[1,2-a][1,4]benzodiazepine Chemical class C1=CC(CC(F)F)=CC=C1C1=CC=C2N1C1=CC=CC=C1CN=C2 LBZJYBQJOOMCGP-UHFFFAOYSA-N 0.000 title abstract 2
- NYUDTAIEZFWBLV-UHFFFAOYSA-N 4-[2-(2,2-difluoroethyl)phenyl]-5,6-dihydro-4h-pyrrolo[1,2-a][1,4]benzodiazepine Chemical compound FC(F)CC1=CC=CC=C1C1C2=CC=CN2C2=CC=CC=C2CN1 NYUDTAIEZFWBLV-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010017533 Fungal infection Diseases 0.000 abstract 2
- 208000031888 Mycoses Diseases 0.000 abstract 2
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 abstract 1
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 abstract 1
- 241001480043 Arthrodermataceae Species 0.000 abstract 1
- 241000985243 Arthrographis Species 0.000 abstract 1
- 241000228212 Aspergillus Species 0.000 abstract 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 241000222173 Candida parapsilosis Species 0.000 abstract 1
- 201000007336 Cryptococcosis Diseases 0.000 abstract 1
- 241000221204 Cryptococcus neoformans Species 0.000 abstract 1
- 241001123635 Dipodascus Species 0.000 abstract 1
- 241001480036 Epidermophyton floccosum Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 241000223218 Fusarium Species 0.000 abstract 1
- 241000555688 Malassezia furfur Species 0.000 abstract 1
- 241001480037 Microsporum Species 0.000 abstract 1
- 241000306281 Mucor ambiguus Species 0.000 abstract 1
- 241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 abstract 1
- 241000228143 Penicillium Species 0.000 abstract 1
- 241000235402 Rhizomucor Species 0.000 abstract 1
- 241000235527 Rhizopus Species 0.000 abstract 1
- 241000132889 Scedosporium Species 0.000 abstract 1
- 241000122799 Scopulariopsis Species 0.000 abstract 1
- 241000223255 Scytalidium Species 0.000 abstract 1
- 241001149963 Sporothrix schenckii Species 0.000 abstract 1
- 241001523006 Talaromyces marneffei Species 0.000 abstract 1
- 241000223259 Trichoderma Species 0.000 abstract 1
- 241000223238 Trichophyton Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940055022 candida parapsilosis Drugs 0.000 abstract 1
- 230000037304 dermatophytes Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10165076 | 2010-06-07 | ||
| PCT/EP2011/059058 WO2011154298A1 (en) | 2010-06-07 | 2011-06-01 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ602981A true NZ602981A (en) | 2013-11-29 |
Family
ID=42294978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ602981A NZ602981A (en) | 2010-06-07 | 2011-06-01 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9637490B2 (enExample) |
| EP (1) | EP2576557B1 (enExample) |
| JP (4) | JP5922107B2 (enExample) |
| KR (1) | KR101886136B1 (enExample) |
| CN (1) | CN102947307B (enExample) |
| AP (1) | AP3285A (enExample) |
| AR (1) | AR081642A1 (enExample) |
| AU (1) | AU2011263946B2 (enExample) |
| BR (1) | BR112012030895A2 (enExample) |
| CA (1) | CA2799634C (enExample) |
| EA (1) | EA021220B1 (enExample) |
| ES (1) | ES2489191T3 (enExample) |
| JO (1) | JO3029B1 (enExample) |
| MX (1) | MX2012014271A (enExample) |
| MY (1) | MY156731A (enExample) |
| NZ (1) | NZ602981A (enExample) |
| PH (1) | PH12012502293A1 (enExample) |
| SG (1) | SG185650A1 (enExample) |
| TW (1) | TWI500619B (enExample) |
| UA (1) | UA107963C2 (enExample) |
| WO (1) | WO2011154298A1 (enExample) |
| ZA (1) | ZA201209246B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ587490A (en) * | 2010-08-20 | 2013-03-28 | Greentide Ltd | Anti-Microbial Compounds containing compounds with a sugar substituent |
| CA2816395C (en) * | 2010-11-24 | 2019-03-12 | Janssen Pharmaceutica Nv | Antifungal 5,6-dihydro-4h-pyrrolo[1,2-a] [1,4]- benzodiazepines and 6h-pyrrolo[1,2-a] [1,4]benzodiazepines substituted with phenyl derivatives |
| AU2013204604B2 (en) * | 2012-05-30 | 2016-05-19 | Biodiem Limited | Method of treating Scedosporium spp. infection |
| JP6197348B2 (ja) * | 2013-04-25 | 2017-09-20 | セントラル硝子株式会社 | α，α−ジフルオロ芳香族化合物の保存安定性の向上方法 |
| RU2771019C1 (ru) * | 2021-06-29 | 2022-04-25 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | Применение 10-метил-2-(трифторметил)-6,7-дигидро-5Н-бензо[b]пирроло[1,2-d][1,4]диазепина в качестве антибактериального средства в отношении грамположительных микроорганизмов |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1392691B1 (en) | 2000-10-23 | 2009-05-20 | Janssen Pharmaceutica N.V. | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a] [1,4] benzodiazepines |
-
2011
- 2011-01-06 UA UAA201211701A patent/UA107963C2/uk unknown
- 2011-05-30 JO JOP/2011/0174A patent/JO3029B1/ar active
- 2011-06-01 EP EP11723445.0A patent/EP2576557B1/en active Active
- 2011-06-01 PH PH1/2012/502293A patent/PH12012502293A1/en unknown
- 2011-06-01 KR KR1020127030661A patent/KR101886136B1/ko not_active Expired - Fee Related
- 2011-06-01 US US13/702,361 patent/US9637490B2/en active Active
- 2011-06-01 AP AP2012006502A patent/AP3285A/xx active
- 2011-06-01 EA EA201291401A patent/EA021220B1/ru not_active IP Right Cessation
- 2011-06-01 BR BR112012030895A patent/BR112012030895A2/pt not_active Application Discontinuation
- 2011-06-01 NZ NZ602981A patent/NZ602981A/xx not_active IP Right Cessation
- 2011-06-01 AU AU2011263946A patent/AU2011263946B2/en not_active Ceased
- 2011-06-01 CN CN201180028301.XA patent/CN102947307B/zh active Active
- 2011-06-01 MX MX2012014271A patent/MX2012014271A/es active IP Right Grant
- 2011-06-01 JP JP2013513625A patent/JP5922107B2/ja active Active
- 2011-06-01 WO PCT/EP2011/059058 patent/WO2011154298A1/en not_active Ceased
- 2011-06-01 CA CA2799634A patent/CA2799634C/en active Active
- 2011-06-01 SG SG2012084901A patent/SG185650A1/en unknown
- 2011-06-01 ES ES11723445.0T patent/ES2489191T3/es active Active
- 2011-06-01 MY MYPI2012005016A patent/MY156731A/en unknown
- 2011-06-03 TW TW100119491A patent/TWI500619B/zh not_active IP Right Cessation
- 2011-06-06 AR ARP110101951A patent/AR081642A1/es unknown
-
2012
- 2012-12-06 ZA ZA2012/09246A patent/ZA201209246B/en unknown
-
2016
- 2016-01-13 JP JP2016004295A patent/JP6208263B2/ja active Active
-
2017
- 2017-09-06 JP JP2017170727A patent/JP6505176B2/ja not_active Expired - Fee Related
-
2019
- 2019-03-26 JP JP2019057689A patent/JP6653036B2/ja active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 JUN 2018 BY CPA GLOBAL Effective date: 20140903 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 JUN 2019 BY CPA GLOBAL Effective date: 20180503 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 JUN 2020 BY CPA GLOBAL Effective date: 20190502 |
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| LAPS | Patent lapsed |