CN102947307B - 抗真菌性5,6-二氢-4-[(二氟乙基)苯基]-4H-吡咯并[1,2-a][1,4]苯并二氮*和4-(二氟乙基)苯基-6H-吡咯并[1,2-a][1,4]苯并二氮*衍生物 - Google Patents

抗真菌性5,6-二氢-4-[(二氟乙基)苯基]-4H-吡咯并[1,2-a][1,4]苯并二氮*和4-(二氟乙基)苯基-6H-吡咯并[1,2-a][1,4]苯并二氮*衍生物 Download PDF

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Publication number
CN102947307B
CN102947307B CN201180028301.XA CN201180028301A CN102947307B CN 102947307 B CN102947307 B CN 102947307B CN 201180028301 A CN201180028301 A CN 201180028301A CN 102947307 B CN102947307 B CN 102947307B
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compound
compounds
fluorine
formula
hydrogen
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Chinese (zh)
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CN102947307A (zh
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L.米尔波尔
L.J.R.M.梅斯
K.德维特
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201180028301.XA 2010-06-07 2011-06-01 抗真菌性5,6-二氢-4-[(二氟乙基)苯基]-4H-吡咯并[1,2-a][1,4]苯并二氮*和4-(二氟乙基)苯基-6H-吡咯并[1,2-a][1,4]苯并二氮*衍生物 Active CN102947307B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10165076 2010-06-07
EP10165076.0 2010-06-07
PCT/EP2011/059058 WO2011154298A1 (en) 2010-06-07 2011-06-01 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES

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CN102947307A CN102947307A (zh) 2013-02-27
CN102947307B true CN102947307B (zh) 2015-03-18

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CN201180028301.XA Active CN102947307B (zh) 2010-06-07 2011-06-01 抗真菌性5,6-二氢-4-[(二氟乙基)苯基]-4H-吡咯并[1,2-a][1,4]苯并二氮*和4-(二氟乙基)苯基-6H-吡咯并[1,2-a][1,4]苯并二氮*衍生物

Country Status (22)

Country Link
US (1) US9637490B2 (enExample)
EP (1) EP2576557B1 (enExample)
JP (4) JP5922107B2 (enExample)
KR (1) KR101886136B1 (enExample)
CN (1) CN102947307B (enExample)
AP (1) AP3285A (enExample)
AR (1) AR081642A1 (enExample)
AU (1) AU2011263946B2 (enExample)
BR (1) BR112012030895A2 (enExample)
CA (1) CA2799634C (enExample)
EA (1) EA021220B1 (enExample)
ES (1) ES2489191T3 (enExample)
JO (1) JO3029B1 (enExample)
MX (1) MX2012014271A (enExample)
MY (1) MY156731A (enExample)
NZ (1) NZ602981A (enExample)
PH (1) PH12012502293A1 (enExample)
SG (1) SG185650A1 (enExample)
TW (1) TWI500619B (enExample)
UA (1) UA107963C2 (enExample)
WO (1) WO2011154298A1 (enExample)
ZA (1) ZA201209246B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ587490A (en) * 2010-08-20 2013-03-28 Greentide Ltd Anti-Microbial Compounds containing compounds with a sugar substituent
UA109676C2 (xx) * 2010-11-24 2015-09-25 ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4H-ПІРОЛО$1,2-а]$1,4]БЕНЗОДІАЗЕПІНИ І 6H-ПІРОЛО$1,2-а]$1,4]БЕНЗОДІАЗЕПІНИ, ЗАМІЩЕНІ ФЕНІЛЬНИМИ ПОХІДНИМИ
AU2013204604B2 (en) * 2012-05-30 2016-05-19 Biodiem Limited Method of treating Scedosporium spp. infection
JP6197348B2 (ja) * 2013-04-25 2017-09-20 セントラル硝子株式会社 α，α−ジフルオロ芳香族化合物の保存安定性の向上方法
RU2771019C1 (ru) * 2021-06-29 2022-04-25 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Применение 10-метил-2-(трифторметил)-6,7-дигидро-5Н-бензо[b]пирроло[1,2-d][1,4]диазепина в качестве антибактериального средства в отношении грамположительных микроорганизмов

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034752A1 (en) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]benzodiazepines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034752A1 (en) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]benzodiazepines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents;Lieven Meerpoel等;《BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS》;20050715;第15卷(第14期);第3454页 *

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Publication number Publication date
JP2018021060A (ja) 2018-02-08
AP2012006502A0 (en) 2012-10-31
CA2799634A1 (en) 2011-12-15
KR20130113922A (ko) 2013-10-16
EP2576557B1 (en) 2014-05-21
EP2576557A1 (en) 2013-04-10
JP2019112460A (ja) 2019-07-11
UA107963C2 (xx) 2015-03-10
CA2799634C (en) 2018-07-10
TWI500619B (zh) 2015-09-21
ZA201209246B (en) 2015-06-24
AP3285A (en) 2015-05-31
JP2016128450A (ja) 2016-07-14
AU2011263946B2 (en) 2014-10-30
MX2012014271A (es) 2013-01-24
JP6208263B2 (ja) 2017-10-04
HK1178152A1 (en) 2013-09-06
JP5922107B2 (ja) 2016-05-24
TW201211045A (en) 2012-03-16
EA021220B1 (ru) 2015-04-30
PH12012502293A1 (en) 2022-10-05
JO3029B1 (ar) 2016-09-05
BR112012030895A2 (pt) 2016-11-08
US9637490B2 (en) 2017-05-02
AU2011263946A1 (en) 2012-11-08
WO2011154298A1 (en) 2011-12-15
AR081642A1 (es) 2012-10-10
NZ602981A (en) 2013-11-29
US20130085136A1 (en) 2013-04-04
EA201291401A1 (ru) 2013-04-30
CN102947307A (zh) 2013-02-27
KR101886136B1 (ko) 2018-08-07
JP6653036B2 (ja) 2020-02-26
MY156731A (en) 2016-03-15
JP2013528192A (ja) 2013-07-08
ES2489191T3 (es) 2014-09-01
JP6505176B2 (ja) 2019-04-24
SG185650A1 (en) 2012-12-28

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