KR101886136B1 - 신규한 항진균성 5,6-디하이드로-4-[(디플루오로에틸)페닐]-4H-피롤로[1,2-α][1,4]벤조디아제핀 및 4-(디플루오로에틸)페닐-6H-피롤로[1,2-α][1,4]벤조디아제핀 유도체 - Google Patents

신규한 항진균성 5,6-디하이드로-4-[(디플루오로에틸)페닐]-4H-피롤로[1,2-α][1,4]벤조디아제핀 및 4-(디플루오로에틸)페닐-6H-피롤로[1,2-α][1,4]벤조디아제핀 유도체 Download PDF

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Publication number
KR101886136B1
KR101886136B1 KR1020127030661A KR20127030661A KR101886136B1 KR 101886136 B1 KR101886136 B1 KR 101886136B1 KR 1020127030661 A KR1020127030661 A KR 1020127030661A KR 20127030661 A KR20127030661 A KR 20127030661A KR 101886136 B1 KR101886136 B1 KR 101886136B1
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KR
South Korea
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spp
fluoro
compound
chloro
formula
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KR1020127030661A
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Korean (ko)
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KR20130113922A (ko
Inventor
리벤 미르포엘
루이스 줄리스 로게르 마리에 매스
비트 켈리 데
비트 켈리 데
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얀센 파마슈티카 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020127030661A 2010-06-07 2011-06-01 신규한 항진균성 5,6-디하이드로-4-[(디플루오로에틸)페닐]-4H-피롤로[1,2-α][1,4]벤조디아제핀 및 4-(디플루오로에틸)페닐-6H-피롤로[1,2-α][1,4]벤조디아제핀 유도체 Expired - Fee Related KR101886136B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10165076.0 2010-06-07
EP10165076 2010-06-07
PCT/EP2011/059058 WO2011154298A1 (en) 2010-06-07 2011-06-01 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES

Publications (2)

Publication Number Publication Date
KR20130113922A KR20130113922A (ko) 2013-10-16
KR101886136B1 true KR101886136B1 (ko) 2018-08-07

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KR1020127030661A Expired - Fee Related KR101886136B1 (ko) 2010-06-07 2011-06-01 신규한 항진균성 5,6-디하이드로-4-[(디플루오로에틸)페닐]-4H-피롤로[1,2-α][1,4]벤조디아제핀 및 4-(디플루오로에틸)페닐-6H-피롤로[1,2-α][1,4]벤조디아제핀 유도체

Country Status (22)

Country Link
US (1) US9637490B2 (enExample)
EP (1) EP2576557B1 (enExample)
JP (4) JP5922107B2 (enExample)
KR (1) KR101886136B1 (enExample)
CN (1) CN102947307B (enExample)
AP (1) AP3285A (enExample)
AR (1) AR081642A1 (enExample)
AU (1) AU2011263946B2 (enExample)
BR (1) BR112012030895A2 (enExample)
CA (1) CA2799634C (enExample)
EA (1) EA021220B1 (enExample)
ES (1) ES2489191T3 (enExample)
JO (1) JO3029B1 (enExample)
MX (1) MX2012014271A (enExample)
MY (1) MY156731A (enExample)
NZ (1) NZ602981A (enExample)
PH (1) PH12012502293A1 (enExample)
SG (1) SG185650A1 (enExample)
TW (1) TWI500619B (enExample)
UA (1) UA107963C2 (enExample)
WO (1) WO2011154298A1 (enExample)
ZA (1) ZA201209246B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ587490A (en) * 2010-08-20 2013-03-28 Greentide Ltd Anti-Microbial Compounds containing compounds with a sugar substituent
WO2012069380A1 (en) * 2010-11-24 2012-05-31 Janssen Pharmaceutica Nv Antifungal 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]-benzodiazepines and 6h-pyrrolo[1,2-a][1,4]benzodiazepines substituted with phenyl derivatives
AU2013204604B2 (en) * 2012-05-30 2016-05-19 Biodiem Limited Method of treating Scedosporium spp. infection
JP6197348B2 (ja) * 2013-04-25 2017-09-20 セントラル硝子株式会社 α，α−ジフルオロ芳香族化合物の保存安定性の向上方法
RU2771019C1 (ru) * 2021-06-29 2022-04-25 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Применение 10-метил-2-(трифторметил)-6,7-дигидро-5Н-бензо[b]пирроло[1,2-d][1,4]диазепина в качестве антибактериального средства в отношении грамположительных микроорганизмов

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034752A1 (en) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]benzodiazepines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034752A1 (en) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]benzodiazepines

Also Published As

Publication number Publication date
SG185650A1 (en) 2012-12-28
JP2019112460A (ja) 2019-07-11
BR112012030895A2 (pt) 2016-11-08
TW201211045A (en) 2012-03-16
JP6208263B2 (ja) 2017-10-04
WO2011154298A1 (en) 2011-12-15
MX2012014271A (es) 2013-01-24
PH12012502293A1 (en) 2022-10-05
US9637490B2 (en) 2017-05-02
AR081642A1 (es) 2012-10-10
JP2013528192A (ja) 2013-07-08
JO3029B1 (ar) 2016-09-05
AP2012006502A0 (en) 2012-10-31
AU2011263946B2 (en) 2014-10-30
JP2018021060A (ja) 2018-02-08
EP2576557A1 (en) 2013-04-10
CN102947307B (zh) 2015-03-18
JP5922107B2 (ja) 2016-05-24
UA107963C2 (xx) 2015-03-10
EP2576557B1 (en) 2014-05-21
NZ602981A (en) 2013-11-29
CN102947307A (zh) 2013-02-27
TWI500619B (zh) 2015-09-21
EA201291401A1 (ru) 2013-04-30
AP3285A (en) 2015-05-31
HK1178152A1 (en) 2013-09-06
ZA201209246B (en) 2015-06-24
US20130085136A1 (en) 2013-04-04
MY156731A (en) 2016-03-15
AU2011263946A1 (en) 2012-11-08
KR20130113922A (ko) 2013-10-16
JP6505176B2 (ja) 2019-04-24
CA2799634A1 (en) 2011-12-15
ES2489191T3 (es) 2014-09-01
EA021220B1 (ru) 2015-04-30
JP6653036B2 (ja) 2020-02-26
CA2799634C (en) 2018-07-10
JP2016128450A (ja) 2016-07-14

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